Abstract:
:The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.
journal_name
Dev Celljournal_title
Developmental cellauthors
Bazan JF,Janda CY,Garcia KCdoi
10.1016/j.devcel.2012.07.011subject
Has Abstractpub_date
2012-08-14 00:00:00pages
227-32issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(12)00330-9journal_volume
23pub_type
杂志文章abstract::The biogenesis of lipid droplets (LDs) and the development of adipocytes are two key aspects of mammalian fat storage. SEIPIN, an integral membrane protein of the endoplasmic reticulum (ER), plays a critical role in both LD formation and adipogenesis. The molecular function of SEIPIN, however, has yet to be elucidated...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.09.010
更新日期:2018-10-22 00:00:00
abstract::Constitutive exocytosis delivers newly synthesized proteins, lipids, and other molecules from the Golgi apparatus to the cell surface. This process is mediated by vesicles, which bud off the trans-Golgi network, move along cytoskeletal filaments, and fuse with the plasma membrane. Here, we show that the small GTPase R...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2007.06.010
更新日期:2007-08-01 00:00:00
abstract::The zona pellucida surrounding ovulated mouse eggs contains three glycoproteins, two of which (ZP2 and ZP3) are reported sperm receptors. After fertilization, the zona pellucida is modified ad minimus by cleavage of ZP2, and sperm no longer bind. Crosstaxa sperm binding is limited among mammals, and human sperm do not...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00195-3
更新日期:2003-07-01 00:00:00
abstract::Positioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.10.009
更新日期:2016-11-07 00:00:00
abstract::The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR) complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent years. It has become increasingly evident that these regulatory circuits control some of the most fundamental aspects of metabolism, c...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2007.03.020
更新日期:2007-04-01 00:00:00
abstract::In organellogenesis of the chloroplast from endosymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should have been pivotal. However, it is still mysterious how these mechanisms were established and how they work in plant cells. Here we show that AKR2A, the cytosolic targetin...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.07.026
更新日期:2014-09-08 00:00:00
abstract::Recent studies have yielded a number of important insights into the mechanisms of hair follicle development and cycling and have highlighted the particularly important roles played by stem cells and Wnt signaling pathways. ...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/s1534-5807(01)00022-3
更新日期:2001-07-01 00:00:00
abstract::The ability of cells to form and release multiple classes of extracellular vesicles (EVs) is an increasingly well-recognized phenomenon. EVs are best known as mediators of intercellular communication. However, in a recent issue of Nature, Keller et al. show that they function as decoys to mitigate bacterial toxins. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2020.03.022
更新日期:2020-04-20 00:00:00
abstract::The appearance of Oskar protein occurs coincident with localization of oskar mRNA to the posterior pole of the Drosophila oocyte, and earlier accumulation of the protein is prevented by translational repression. We find that the nascent polypeptide-associated complex (NAC) is required for correct localization of oskar...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2004.06.009
更新日期:2004-07-01 00:00:00
abstract::The Rho GTPase Cdc42 is essential for polarized growth of budding yeast. Temporal control of Cdc42 depends partly on the activity of its GTPase-activating proteins (GAPs). In this issue of Developmental Cell, Saito et al. report that Cdc42 GAP activity is regulated by the phospholipid composition of the bud-tip membra...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2007.10.008
更新日期:2007-11-01 00:00:00
abstract::During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in melanoblasts during embryogenesis causes defects in migration, cell-cycle progression, and cytokinesis. Rac1 null cells migrate markedly less efficiently, but s...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.07.008
更新日期:2011-10-18 00:00:00
abstract::Exposure to environmental teratogenic pollutant leads to severe birth defects. However, the biological events underlying these developmental abnormalities remain undefined. Here, we report a molecular link between an environmental stress response pathway and key developmental genes during craniofacial development. Str...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.02.006
更新日期:2015-04-06 00:00:00
abstract::The blood brain barrier (BBB) is critical to ensure proper nervous system function and organismal health. In this issue of Developmental Cell, Babatz and colleagues explore the mechanisms of BBB maintenance and uncover a potential evolutionary link by which BBB glia construct paracellular barriers to ensure uninterrup...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2018.11.036
更新日期:2018-12-17 00:00:00
abstract::Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-threonine kinase domain. Here, we find that Trpm7-/- T cells are deficient in Fas-receptor-induced apoptosis and that TRPM7 channel activity participates in the apoptotic process and is regulated by caspa...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.04.006
更新日期:2012-06-12 00:00:00
abstract::By functioning as an enzyme cofactor, hemoglobin component, and gene regulator, heme is vital for life. One mode of heme-regulated transcription involves amplifying the activity of GATA-1, a key determinant of erythrocyte differentiation. To discover biological consequences of the metal cofactor-transcription factor m...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.07.022
更新日期:2018-09-10 00:00:00
abstract::All complex multicellular organisms must solve the problem of generating diverse and appropriately patterned cell types. Asymmetric division, in which a single mother cell gives rise to daughters with distinct identities, is instrumental in the generation of cellular diversity and higher-level patterns. In animal syst...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2009.05.014
更新日期:2009-06-01 00:00:00
abstract::Pancreatic beta cell proliferation is high at birth and then rapidly declines. In this issue of Developmental Cell,Stolovich-Rain et al. (2015) show that β cells' capacity to increase proliferation in response to injury is unexpectedly not acquired until after weaning-related nutritional changes trigger a metabolic an...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.02.016
更新日期:2015-03-09 00:00:00
abstract::One G protein-coupled receptor (GPCR) can activate more than one G protein, but the physiologic importance of such activation has not been demonstrated in vivo. We have generated mice expressing exclusively a mutant form of the PTH/PTHrP receptor (DSEL) that activates adenylyl cyclase normally but not phospholipase C ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00218-6
更新日期:2002-08-01 00:00:00
abstract::Recent data indicate that cystic fibrosis (CF) airway mucus is anaerobic. This suggests that Pseudomonas aeruginosa infection in CF reflects biofilm formation and persistence in an anaerobic environment. P. aeruginosa formed robust anaerobic biofilms, the viability of which requires rhl quorum sensing and nitric oxide...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00295-2
更新日期:2002-10-01 00:00:00
abstract::Alzheimer's disease remains a formidable challenge for therapeutic management. In a recent report in Nature Structural and Molecular Biology, Cohen et al. (2015) present intriguing results showing that "designer" molecular chaperones may hold the key to an evolutionarily conserved program for management of toxic oligo...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.03.009
更新日期:2015-03-23 00:00:00
abstract::The early midgut undergoes intensive elongation, but the underlying cellular and molecular mechanisms are unknown. The early midgut epithelium is pseudostratified, and its nuclei travel between apical and basal surfaces in concert with cell cycle. Using 3D confocal imaging and 2D live imaging, we profiled behaviors of...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.06.011
更新日期:2018-07-16 00:00:00
abstract::Chronic inflammation is associated with tumorigenesis, but how acute inflammation affects the tumor microenvironment is less known. Recently, Antonio et al. (2015) found that neutrophils attracted to an acute wound such as a biopsy drive cell proliferation of nearby pre-neoplastic cells, suggesting that acute wounds m...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.07.005
更新日期:2015-07-27 00:00:00
abstract::The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell abl...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.11.025
更新日期:2015-12-21 00:00:00
abstract::DNA crosslinking agents are commonly used in cancer chemotherapy; however, responses of normal tissues to these agents have not been widely investigated. We reveal in mouse interfollicular epidermal, mammary and hair follicle epithelia that genotoxicity does not promote apoptosis but paradoxically induces hyperplasia ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.09.021
更新日期:2020-12-07 00:00:00
abstract::Enhancers are the primary determinants of cell identity, but the regulatory components controlling enhancer turnover during lineage commitment remain largely unknown. Here we compare the enhancer landscape, transcriptional factor occupancy, and transcriptomic changes in human fetal and adult hematopoietic stem/progeni...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.12.014
更新日期:2016-01-11 00:00:00
abstract::Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in various embryonic and adult tissues. Mice mutant for either Tet1 or Tet2 are viable, raising the question of whether these enzymes have overlapping roles in development. Here we have generated Tet1 and Tet2 double-knockout (DKO)...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.12.015
更新日期:2013-02-11 00:00:00
abstract::CPEB is a sequence-specific RNA binding protein that regulates translation during vertebrate oocyte maturation. Adult female CPEB knockout mice contained vestigial ovaries that were devoid of oocytes; ovaries from mid-gestation embryos contained oocytes that were arrested at the pachytene stage. Male CPEB null mice al...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(01)00025-9
更新日期:2001-08-01 00:00:00
abstract::Bacteria display an array of contact-dependent interaction systems that have evolved to facilitate direct cell-to-cell communication. We have previously identified a mode of bacterial communication mediated by nanotubes bridging neighboring cells. Here, we elucidate nanotube architecture, dynamics, and molecular compo...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.01.013
更新日期:2016-02-22 00:00:00
abstract::During early embryonic development, cells are organized as cohesive epithelial sheets that are continuously growing and remodeled without losing their integrity, giving rise to a wide array of tissue shapes. Here, using live imaging in chick embryo, we investigate how epithelial cells rearrange during gastrulation. We...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.01.007
更新日期:2016-02-08 00:00:00
abstract::Steroid hormones have long been thought to enter target cells via passive diffusion through the plasma membrane. Now, reporting in Developmental Cell, Okamoto et al. (2018) demonstrate that, at least for Drosophila, steroid hormones require a protein transporter for cellular entry. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2018.10.022
更新日期:2018-11-05 00:00:00