Structural architecture and functional evolution of Wnts.

Abstract:

:The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Bazan JF,Janda CY,Garcia KC

doi

10.1016/j.devcel.2012.07.011

subject

Has Abstract

pub_date

2012-08-14 00:00:00

pages

227-32

issue

2

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(12)00330-9

journal_volume

23

pub_type

杂志文章
  • Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis.

    abstract::Signaling receptors are internalized and regulated by clathrin-mediated endocytosis (CME). Two clathrin light chain isoforms, CLCa and CLCb, are integral components of the endocytic machinery whose differential functions remain unknown. We report that CLCb is specifically upregulated in non-small-cell lung cancer (NSC...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2017.01.007

    authors: Chen PH,Bendris N,Hsiao YJ,Reis CR,Mettlen M,Chen HY,Yu SL,Schmid SL

    更新日期:2017-02-06 00:00:00

  • Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation.

    abstract::The Cubitus interruptus (Ci)/Gli family of transcription factors can be degraded either completely or partially from a full-length form (Ci155/Gli(FL)) to a truncated repressor (Ci75/Gli(R)) by proteasomes to mediate Hedgehog (Hh) signaling. The mechanism by which proteasomes distinguish ubiquitinated Ci/Gli to carry ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.05.006

    authors: Zhang Z,Lv X,Yin WC,Zhang X,Feng J,Wu W,Hui CC,Zhang L,Zhao Y

    更新日期:2013-06-24 00:00:00

  • Tensing Up for Lipid Droplet Formation.

    abstract::Lipid droplets are fat storage organelles in cells that physically resemble stable oil-water emulsion droplets. In this issue of Developmental Cell, Ben M'barek et al. (2017) show that the resemblance is more than superficial: physical principles governing emulsion stability also control lipid droplet nucleation and g...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.devcel.2017.06.001

    authors: Roux A,Loewith R

    更新日期:2017-06-19 00:00:00

  • Mammalian limbs take flight.

    abstract::Tetrapod limbs display a great variety of forms and functions. In an attempt to understand factors influencing this diversity, Cretekos and colleagues, in a recent issue of Genes & Development, provide molecular insight into the evolution of wing morphology in bats. ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.01.011

    authors: Weatherbee SD

    更新日期:2008-02-01 00:00:00

  • RA Gets Out of the Way to Allow High-Acuity Vision.

    abstract::Specialized areas in the vertebrate retina are critical for high-acuity vision, yet the molecular mechanisms driving the development of high-acuity areas (HAAs) remain largely unknown. In Developmental Cell, da Silva and Cepko (2017) show that restricted degradation of retinoic acid and elevated FGF8 signaling give ri...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2017.06.015

    authors: Tufford A,Cayouette M

    更新日期:2017-07-10 00:00:00

  • The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway.

    abstract::The Hippo (Hpo) signaling pathway controls tissue growth and organ size in species ranging from Drosophila to mammals and is deregulated in a wide range of human cancers. The core pathway consists of the Hpo/Warts (Wts) kinase cassette that phosphorylates and inactivates the transcriptional coactivator Yorkie (Yki). H...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.12.011

    authors: Yue T,Tian A,Jiang J

    更新日期:2012-02-14 00:00:00

  • Model organisms as a guide to mammalian aging.

    abstract::Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/s1534-5807(01)00098-3

    authors: Tissenbaum HA,Guarente L

    更新日期:2002-01-01 00:00:00

  • Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.

    abstract::Angiogenesis is responsible for tissue vascularization during development, as well as in pathological contexts, including cancer and ischemia. Vascular endothelial growth factors (VEGFs) regulate angiogenesis by acting through VEGF receptors to induce endothelial cell signaling. VEGF is processed in the extracellular ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2016.12.017

    authors: De Angelis JE,Lagendijk AK,Chen H,Tromp A,Bower NI,Tunny KA,Brooks AJ,Bakkers J,Francois M,Yap AS,Simons C,Wicking C,Hogan BM,Smith KA

    更新日期:2017-01-23 00:00:00

  • MicroRNAs Establish the Right-Handed Dominance of the Heart Laterality Pathway in Vertebrates.

    abstract::Despite their external bilateral symmetry, vertebrates have internal left/right (L/R) asymmetries required for optimal organ function. BMP-induced epithelial to mesenchymal transition (EMT) in the lateral plate mesoderm (LPM) triggers L/R asymmetric cell movements toward the midline, higher from the right, which are c...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.09.012

    authors: Rago L,Castroviejo N,Fazilaty H,Garcia-Asencio F,Ocaña OH,Galcerán J,Nieto MA

    更新日期:2019-11-18 00:00:00

  • Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos.

    abstract::Connecting phosphorylation events to kinases and phosphatases is key to understanding the molecular organization and signaling dynamics of networks. We have generated a validated set of transgenic RNA-interference reagents for knockdown and characterization of all protein kinases and phosphatases present during early ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2014.07.027

    authors: Sopko R,Foos M,Vinayagam A,Zhai B,Binari R,Hu Y,Randklev S,Perkins LA,Gygi SP,Perrimon N

    更新日期:2014-10-13 00:00:00

  • Germ Cells Get by with a Little Cannibalistic Help from Their Friends.

    abstract::During development, primordial germ cells (PGCs) navigate a complex journey to generate the germline. In a recent paper in Nature Cell Biology, Nance and colleagues (Abdu et al., 2016) have discovered an unexpected step along the way: PGCs get cut in half by endodermal cells. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2016.12.003

    authors: Krishna S,Overholtzer M

    更新日期:2016-12-19 00:00:00

  • Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction.

    abstract::Heparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes. Here, we show that the transmembrane protein, Nogo-A, inhibits neurite outgrowth and cell spreading in neurons and Nogo-A-responsive cell lines via HSPGs. The extracellular, active 180 amino acid Nogo-A regio...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2017.08.014

    authors: Kempf A,Boda E,Kwok JCF,Fritz R,Grande V,Kaelin AM,Ristic Z,Schmandke A,Schmandke A,Tews B,Fawcett JW,Pertz O,Buffo A,Schwab ME

    更新日期:2017-10-09 00:00:00

  • The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage.

    abstract::The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic progenitors. Prox1 specifies lymphatic fate and labels these progenitors;...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.03.017

    authors: Baek S,Oh TG,Secker G,Sutton DL,Okuda KS,Paterson S,Bower NI,Toubia J,Koltowska K,Capon SJ,Baillie GJ,Simons C,Muscat GEO,Lagendijk AK,Smith KA,Harvey NL,Hogan BM

    更新日期:2019-04-22 00:00:00

  • Tracing cells for tracking cell lineage and clonal behavior.

    abstract::Reconstructing the lineage of cells is central to understanding development and is now also an important issue in stem cell research. Technological advances in genetically engineered permanent cell labeling, together with a multiplicity of fluorescent markers and sophisticated imaging, open new possibilities for prosp...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.07.019

    authors: Buckingham ME,Meilhac SM

    更新日期:2011-09-13 00:00:00

  • From blood to brain: the neurogenic niche of the crayfish brain.

    abstract::Adult neurogenic niches are present in both vertebrates and invertebrates. Where do stem cells populating these niches originate, and what are the mechanisms maintaining their self-renewal? In this issue of Developmental Cell, Benton et al. (2014) show that in crayfish, hemolymph-derived cells enter a neurogenic niche...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2014.07.024

    authors: Hartenstein V

    更新日期:2014-08-11 00:00:00

  • The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.

    abstract::To ensure equal chromosome segregation during mitosis, the macromolecular kinetochore must remain attached to depolymerizing microtubules, which drive chromosome movements. How kinetochores associate with depolymerizing microtubules, which undergo dramatic structural changes forming curved protofilaments, has yet to b...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2012.09.012

    authors: Schmidt JC,Arthanari H,Boeszoermenyi A,Dashkevich NM,Wilson-Kubalek EM,Monnier N,Markus M,Oberer M,Milligan RA,Bathe M,Wagner G,Grishchuk EL,Cheeseman IM

    更新日期:2012-11-13 00:00:00

  • Linking Matrix Rigidity with EMT and Cancer Invasion.

    abstract::The extracellular matrix (ECM) plays a major role in cancer progression through its increased deposition and alignment. In this issue of Developmental Cell, Fattet et al. reveal a pathway in which ECM stiffness promotes EPHA2/LYN complex activation, leading to TWIST1 nuclear localization and triggering EMT in breast c...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2020.06.032

    authors: Ros M,Sala M,Saltel F

    更新日期:2020-08-10 00:00:00

  • Development or Disease: Caspases Balance Growth and Immunity in C. elegans.

    abstract::Caspase proteases execute apoptosis but also function in development. In this issue of Developmental Cell, Weaver et al. report that C. elegans CED-3 caspase promotes animal growth through PMK-1/p38 kinase cleavage, and at the expense of pathogen and stress immunity, revealing an unexpected homeostatic relationship be...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2020.04.006

    authors: Yarychkivska O,Shaham S

    更新日期:2020-05-04 00:00:00

  • Adapting to Barriers: Glial Septate Junctions Stretch to Keep Up.

    abstract::The blood brain barrier (BBB) is critical to ensure proper nervous system function and organismal health. In this issue of Developmental Cell, Babatz and colleagues explore the mechanisms of BBB maintenance and uncover a potential evolutionary link by which BBB glia construct paracellular barriers to ensure uninterrup...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2018.11.036

    authors: Coutinho-Budd J

    更新日期:2018-12-17 00:00:00

  • A receptor for meningococcus: eliciting β-arrestin signaling for barrier breaching.

    abstract::In a recent issue of Cell, Coureuil et al. (2010) show that type IV pili of Neisseria meningitidis-the causative bacterium of cerebrospinal meningitis-bind to the endothelial β2-adrenoceptor and elicit biased β-arrestin signaling resulting in microvilli formation and paracytotic bacterial migration. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2010.12.011

    authors: Tourret J,Finlay BB

    更新日期:2011-01-18 00:00:00

  • Multiplexing MIM.

    abstract::Signaling circuits often coordinate cellular membranes and actin filaments at distinct sites to direct cell behavior. In this issue of Developmental Cell, Bershteyn et al. outline how the molecular scaffold protein, MIM, which bends membranes and binds actin filaments, is at the middle of one such circuit to regulate ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2010.07.021

    authors: Kozminski KG,Schafer DA

    更新日期:2010-08-17 00:00:00

  • Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1.

    abstract::The large GTPase Dynamin 2 (Dyn2) is markedly upregulated in pancreatic cancer, is a potent activator of metastatic migration, and is required for Rac1-mediated formation of lamellipodia. Here we demonstrate an unexpected mechanism of Dyn2 action in these contexts via direct binding to the Rac1 guanine nucleotide exch...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.02.010

    authors: Razidlo GL,Wang Y,Chen J,Krueger EW,Billadeau DD,McNiven MA

    更新日期:2013-03-25 00:00:00

  • Aberrant epigenetic landscape in cancer: how cellular identity goes awry.

    abstract::Appropriate patterns of DNA methylation and histone modifications are required to assure cell identity, and their deregulation can contribute to human diseases, such as cancer. Our aim here is to provide an overview of how epigenetic factors, including genomic DNA methylation, histone modifications, and microRNA regul...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2010.10.005

    authors: Berdasco M,Esteller M

    更新日期:2010-11-16 00:00:00

  • Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium.

    abstract::Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2005.11.016

    authors: Shimada Y,Yonemura S,Ohkura H,Strutt D,Uemura T

    更新日期:2006-02-01 00:00:00

  • Dkk1 Controls Cell-Cell Interaction through Regulation of Non-nuclear β-Catenin Pools.

    abstract::Dickkopf-1 (Dkk1) is a secreted Wnt antagonist with a well-established role in head induction during development. Numerous studies have emerged implicating Dkk1 in various malignancies and neurodegenerative diseases through an unknown mechanism. Using zebrafish gastrulation as a model for collective cell migration, we...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.10.026

    authors: Johansson M,Giger FA,Fielding T,Houart C

    更新日期:2019-12-16 00:00:00

  • Maintaining muscle mitochondria via transsynaptic signaling.

    abstract::Dominant VAPB mutations are implicated in neurodegenerative disease, including amyotrophic lateral sclerosis and spinal muscular atrophy. In the current issue, Han et al. (2012) uncover a mechanism through which the secreted VAPB MSP domain regulates actin organization and mitochondrial function in muscle cells throug...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2012.01.021

    authors: Long JB,Van Vactor D

    更新日期:2012-02-14 00:00:00

  • A Hierarchical Regulatory Landscape during the Multiple Stages of EMT.

    abstract::Epithelial-mesenchymal transition (EMT) enables cells to gain migratory and invasive features underlined by major transcriptional and epigenetic reprogramming. However, most studies have focused on the endpoints of the EMT process, and the epistatic hierarchy of the transcriptional networks underlying EMT has remained...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.12.023

    authors: Meyer-Schaller N,Cardner M,Diepenbruck M,Saxena M,Tiede S,Lüönd F,Ivanek R,Beerenwinkel N,Christofori G

    更新日期:2019-02-25 00:00:00

  • Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration.

    abstract::Zebrafish heart regeneration occurs through the activation of cardiomyocyte proliferation in areas of trauma. Here, we show that within 3 hr of ventricular injury, the entire endocardium undergoes morphological changes and induces expression of the retinoic acid (RA)-synthesizing enzyme raldh2. By one day posttrauma, ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.01.010

    authors: Kikuchi K,Holdway JE,Major RJ,Blum N,Dahn RD,Begemann G,Poss KD

    更新日期:2011-03-15 00:00:00

  • Sealed with a Kiz: How Plk1 ensures spindle pole integrity.

    abstract::The kinase Plk1 plays multiple roles in regulating mitotic progression, including stabilization of spindle poles, but its substrates are largely unknown. A new study by Yamamoto and coworkers has identified a centrosomal protein, Kizuna (Kiz), as a mitotic substrate of Plk1 (Oshimori et al., 2006). Phosphorylation of ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2006.09.012

    authors: Fry AM,Baxter JE

    更新日期:2006-10-01 00:00:00

  • Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.

    abstract::The anterior visceral endoderm plays a pivotal role in establishing anterior-posterior polarity of the mouse embryo, but the molecular nature of the signals required remains to be determined. Here, we demonstrate that Cerberus-like(-/-);Lefty1(-/-) compound mutants can develop a primitive streak ectopically in the emb...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(02)00321-0

    authors: Perea-Gomez A,Vella FD,Shawlot W,Oulad-Abdelghani M,Chazaud C,Meno C,Pfister V,Chen L,Robertson E,Hamada H,Behringer RR,Ang SL

    更新日期:2002-11-01 00:00:00