Structural architecture and functional evolution of Wnts.

Abstract:

:The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Bazan JF,Janda CY,Garcia KC

doi

10.1016/j.devcel.2012.07.011

subject

Has Abstract

pub_date

2012-08-14 00:00:00

pages

227-32

issue

2

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(12)00330-9

journal_volume

23

pub_type

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