Abstract：
:The viral genomes of alpha- and gamma-retroviruses follow an outbound route through the cytoplasm before assembling with the budding particle at the plasma membrane. We show here that murine leukemia virus (MLV) RNAs are transported on lysosomes and transferrin-positive endosomes. Transport on transferrin-positive vesicles requires both Gag and Env polyproteins. In the presence of Env, Gag is rerouted from lysosomes to transferrin-positive endosomes, and virion production becomes highly sensitive to drugs poisoning vesicular and endosomal traffic. Vesicular transport of the RNA does not require prior endocytosis, indicating that it is recruited directly from the cytosol. Viral prebudding complexes containing Env, Gag, and retroviral RNAs are thus formed on endosomes, and subsequently routed to the plasma membrane. This may allow retroviruses to hijack the endosomal machinery as part of their biosynthetic pathway. More generally, tethering to vesicles may provide an efficient mechanism for directed RNA transport.
journal_name
Dev Celljournal_title
Developmental cellauthors
Basyuk E,Galli T,Mougel M,Blanchard JM,Sitbon M,Bertrand Edoi
10.1016/s1534-5807(03)00188-6keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
161-74issue
1eissn
1534-5807issn
1878-1551pii
S1534-5807(03)00188-6journal_volume
5pub_type
杂志文章abstract：:Dynamin family members are large GTPases that assemble into multimeric spirals. These spirals promote membrane fission or fusion, or they inhibit processes such as viral replication. Two new studies by Chappie et al. and Gao et al. in a recent issue of Nature identify interactions between subunits of dynamin spirals, ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.05.001
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abstract：:The capacity to undergo meiosis defines vertebrate germ cells, yet mechanisms driving initiation of this specialized process are largely undefined. In this issue of Developmental Cell,Ishiguro et al. (2020) identified the transcription factor MEIOSIN as a gatekeeper of meiotic initiation in both male and female germ c...
journal_title：Developmental cell
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journal_title：Developmental cell
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abstract：:DSL ligands promote proteolysis of the Notch receptor, to release active Notch intracellular domain (N(ICD)). Conversely, the E3 ubiquitin ligase Deltex can activate ligand-independent Notch proteolysis and signaling. Here we show that Deltex effects require endocytic trafficking by HOPS and AP-3 complexes. Our data s...
journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章
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journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2008-02-01 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.09.015
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.01.013
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.11.007
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journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.12.011
更新日期：2019-01-07 00:00:00
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2010.01.011
更新日期：2010-02-16 00:00:00
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journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.10.022
更新日期：2018-11-05 00:00:00
abstract：:Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the bloodstream, reach distant organs, and locally modify the microenvironment. However, visualizing these events in vivo still faces major hurdles. Here...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.01.014
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.06.009
更新日期：2007-08-01 00:00:00
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章,评审
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更新日期：2002-04-01 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.02.006
更新日期：2006-03-01 00:00:00
abstract：:The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.07.013
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