Abstract：
:The combination of fluid and mechanical properties exhibited by cell membranes enables a wealth of physical phenomena, many of which also have biological functions. A recent study in Cell (Shi et al., 2018) now shows that membrane tension in the cell may not be as simple as it first seemed.
journal_name
Dev Celljournal_title
Developmental cellauthors
Groves JTdoi
10.1016/j.devcel.2018.12.011subject
Has Abstractpub_date
2019-01-07 00:00:00pages
15-16issue
1eissn
1534-5807issn
1878-1551pii
S1534-5807(18)31079-7journal_volume
48pub_type
评论,杂志文章abstract：:Despite their external bilateral symmetry, vertebrates have internal left/right (L/R) asymmetries required for optimal organ function. BMP-induced epithelial to mesenchymal transition (EMT) in the lateral plate mesoderm (LPM) triggers L/R asymmetric cell movements toward the midline, higher from the right, which are c...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.09.012
更新日期：2019-11-18 00:00:00
abstract：:Recently, there has been a surge in the number of pioneering studies combining experiments with quantitative modeling to explain both relatively simple modules of molecular machinery of the cell and to achieve system-level understanding of cellular networks. Here we discuss the utility and methods of modeling and revi...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2006.08.004
更新日期：2006-09-01 00:00:00
abstract：:Morphogenesis of wavy epidermal pavement cells in plants has fascinated researchers for decades. A mechanical mechanism had been proposed in which the anticlinal cell walls, forming the in-plane cell borders, feature contiguous stiff and soft zones that generate waves upon stretching. We replicated this model as desig...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2019.05.001
更新日期：2019-07-01 00:00:00
abstract：:The shape of most complex organ systems arises from the directed migration of cohesive groups of cells. Here, we dissect the role of the chemokine guidance receptor Cxcr4b in regulating the collective migration of one such cohesive tissue, the zebrafish lateral line primordium. Using in vivo imaging, we show that the ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.02.019
更新日期：2006-05-01 00:00:00
abstract：:Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.11.016
更新日期：2006-02-01 00:00:00
abstract：:The eukaryotic nucleus has been the neglected child of cell biology. The "International Symposium on Functional Organization of the Nucleus" held in January on Awaji Island, Japan, highlighted recent work on nuclear organization and function. Emerging from this conference was a holistic view in which diverse chemical ...
journal_title：Developmental cell
pub_type：
doi：10.1016/j.devcel.2007.02.014
更新日期：2007-03-01 00:00:00
abstract：:Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H₂O₂)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly w...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.12.007
更新日期：2011-02-15 00:00:00
abstract：:Heparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes. Here, we show that the transmembrane protein, Nogo-A, inhibits neurite outgrowth and cell spreading in neurons and Nogo-A-responsive cell lines via HSPGs. The extracellular, active 180 amino acid Nogo-A regio...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.08.014
更新日期：2017-10-09 00:00:00
abstract：:Theoretical modeling is central to elucidating underlying principles of emergent properties of complex systems. In cell and developmental biology, the last 15 years have witnessed a convergence of empirical and modeling approaches for fresh perspectives. The role of cell division in coordinating size, shape, and fate ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.09.008
更新日期：2016-09-26 00:00:00
abstract：:Changes in the genetic makeup of an organism can extend lifespan significantly if they promote tolerance to environmental insults and thus prevent the general deterioration of cellular function that is associated with aging. Here, we introduce the Jun N-terminal kinase (JNK) signaling pathway as a genetic determinant ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00323-x
更新日期：2003-11-01 00:00:00
abstract：:Cell locomotion entails functional and structural cooperation between cell surface adhesion and the actin cytoskeleton. A new paper by DeMali et al. provides new insights into the link between actin assembly and integrin adhesion at the leading edges of migrating cells. ...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/s1534-5807(02)00374-x
更新日期：2002-12-01 00:00:00
abstract：:How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migr...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2021.01.002
更新日期：2021-01-25 00:00:00
abstract：:When two colonies of the tunicate Botryllus contact each other, they either fuse into a single colony or mount a destructive reaction, which keeps them apart. Which of the two reactions takes place is determined by a single, highly polymorphic fusion/histocompatibility (FuHC) locus. Recent communications report the cl...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.12.009
更新日期：2006-01-01 00:00:00
abstract：:Serrate (SE) is a key component in RNA metabolism. Little is known about whether and how it can regulate epigenetic silencing. Here, we report histone methyltransferases ATXR5 and ATXR6 (ATXR5/6) as novel partners of SE. ATXR5/6 deposit histone 3 lysine 27 monomethylation (H3K27me1) to promote heterochromatin formatio...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.05.023
更新日期：2018-06-18 00:00:00
abstract：:Spindle positioning is an essential feature of asymmetric cell division. The conserved PAR proteins together with heterotrimeric G proteins control spindle positioning in animal cells, but how these are linked is not known. In C. elegans, PAR protein activity leads to asymmetric spindle placement through cortical asym...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.06.002
更新日期：2008-08-01 00:00:00
abstract：:The Decapentaplegic and Notch signaling pathways are thought to direct regional specification in the Drosophila eye-antennal epithelium by controlling the expression of selector genes for the eye (Eyeless/Pax6, Eyes absent) and/or antenna (Distal-less). Here, we investigate the function of these signaling pathways in ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00243-0
更新日期：2003-09-01 00:00:00
abstract：:MicroRNAs are important regulators of normal and malignant hematopoiesis. A paper by Lu et al. in this issue of Developmental Cell demonstrates how one microRNA, miR-150, plays a critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the widely expressed transcription factor M...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2008.05.011
更新日期：2008-06-01 00:00:00
abstract：:The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids once all chromosomes are attached via kinetochores by microtubules of the mitotic spindle. Reporting in Developmental Cell, Silió et al. (2015) show that in human cells the signaling cascade controlling the checkpoint ope...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.11.021
更新日期：2015-12-07 00:00:00
abstract：:Growth and development are coordinated by an array of intercellular communications. Known plant signaling molecules include phytohormones and hormone peptides. Although both classes can be implicated in the same developmental processes, little is known about the interplay between phytohormone action and peptide signal...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.02.002
更新日期：2012-03-13 00:00:00
abstract：:Oriented cell division plays a key role in controlling organogenesis. The mechanisms for regulating division orientation at the whole-organ level are only starting to become understood. By combining 3D time-lapse imaging, mouse genetics, and mathematical modeling, we find that global orientation of cell division is th...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.12.013
更新日期：2018-02-05 00:00:00
abstract：:In the field of breast biology, there is a growing appreciation for the "gatekeeping function" of basal cells during development and disease processes yet mechanisms regulating the generation of these cells are poorly understood. Here, we report that the proliferation of basal cells is controlled by SLIT/ROBO1 signali...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.05.012
更新日期：2011-06-14 00:00:00
abstract：:The musculoskeletal system of vertebrates is derived from the embryonic mesoderm. Its structures are categorized as epaxial or hypaxial based on their adult position and innervation. The epaxial/hypaxial terminology is also used to describe regions of the embryonic somites based on fate mapping of somitic derivatives....
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/s1534-5807(03)00033-9
更新日期：2003-02-01 00:00:00
abstract：:The mTOR kinase controls cell growth, proliferation, and survival through two distinct multiprotein complexes, mTORC1 and mTORC2. mTOR and mLST8 are in both complexes, while raptor and rictor are part of only mTORC1 and mTORC2, respectively. To investigate mTORC1 and mTORC2 function in vivo, we generated mice deficien...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.10.007
更新日期：2006-12-01 00:00:00
abstract：:The myogenic regulatory genes Myf5, Mrf4, Myod, and Myogenin likely arose by gene duplications during evolution, presumably to address the more demanding requirements of the vertebrate body plan. Two cell lineages were proposed to be regulated independently by Myf5 and Myod to safeguard against tissue failure. Here we...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.11.005
更新日期：2014-12-08 00:00:00
abstract：:CLASPs are mammalian microtubule-stabilizing proteins that can mediate the interaction between distal microtubule ends and the cell cortex. Using mass spectrometry-based assays, we have identified two CLASP partners, LL5beta and ELKS. LL5beta and ELKS form a complex that colocalizes with CLASPs at the cortex of HeLa c...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.05.012
更新日期：2006-07-01 00:00:00
abstract：:Recent studies have demonstrated that MyoD initiates a feed-forward regulation of skeletal muscle gene expression, predicting that MyoD binds directly to many genes expressed during differentiation. We have used chromatin immunoprecipitation and high-throughput sequencing to identify genome-wide binding of MyoD in sev...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.02.014
更新日期：2010-04-20 00:00:00
abstract：:Preventing inappropriate gene expression in time and space is as fundamental as triggering the activation of tissue- or cell-type-specific factors at the correct developmental stage and in the correct cells. Here, we study the impact of Polycomb repressive complex 2 (PRC2) function on HoxA gene regulation. We analyze ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.05.021
更新日期：2019-07-22 00:00:00
abstract：:The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney deve...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.04.012
更新日期：2015-05-04 00:00:00
abstract：:Secreted proteins of the Wnt family affect axon guidance, asymmetric cell division, and cell fate. We show here that C. elegans Wnts acting through Frizzled receptors can shape axon and dendrite trajectories by reversing the anterior-posterior polarity of neurons. In lin-44/Wnt and lin-17/Frizzled mutants, the polarit...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.01.013
更新日期：2006-03-01 00:00:00
abstract：:Understanding the mechanisms driving tissue and organ formation requires knowledge across scales. How do signaling pathways specify distinct tissue types? How does the patterning system control morphogenesis? How do these processes evolve? The Drosophila egg chamber, where EGF and BMP signaling intersect to specify un...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2017.02.018
更新日期：2017-05-22 00:00:00
