Abstract：
:Oriented cell division plays a key role in controlling organogenesis. The mechanisms for regulating division orientation at the whole-organ level are only starting to become understood. By combining 3D time-lapse imaging, mouse genetics, and mathematical modeling, we find that global orientation of cell division is the result of a combination of two types of spindles with distinct spindle dynamic behaviors in the developing airway epithelium. Fixed spindles follow the classic long-axis rule and establish their division orientation before metaphase. In contrast, rotating spindles do not strictly follow the long-axis rule and determine their division orientation during metaphase. By using both a cell-based mechanical model and stretching-lung-explant experiments, we showed that mechanical force can function as a regulatory signal in maintaining the stable ratio between fixed spindles and rotating spindles. Our findings demonstrate that mechanical forces, cell geometry, and oriented cell division function together in a highly coordinated manner to ensure normal airway tube morphogenesis.
journal_name
Dev Celljournal_title
Developmental cellauthors
Tang Z,Hu Y,Wang Z,Jiang K,Zhan C,Marshall WF,Tang Ndoi
10.1016/j.devcel.2017.12.013subject
Has Abstractpub_date
2018-02-05 00:00:00pages
313-325.e5issue
3eissn
1534-5807issn
1878-1551pii
S1534-5807(17)31029-8journal_volume
44pub_type
杂志文章abstract：:Changes to cell shape and interaction drive animal tissue morphogenesis. Reporting now in Developmental Cell, Del Signore et al. (2018) describe active lengthening of cell-cell contacts by Arp2/3-based actin networks. Through cycles of contact lengthening and shortening, the developing Drosophila eye passes through va...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.02.003
更新日期：2018-02-26 00:00:00
abstract：:The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney deve...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.04.012
更新日期：2015-05-04 00:00:00
abstract：:Reactive oxygen species (ROS), despite having damaging roles, serve as signaling molecules regulating diverse biological and physiological processes. Employing in vivo genetic studies in Drosophila, we show that besides causing G1-S arrest by activation of Dacapo, ROS can simultaneously inhibit cell growth by regulati...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.04.008
更新日期：2019-05-06 00:00:00
abstract：:The ability of cells to form and release multiple classes of extracellular vesicles (EVs) is an increasingly well-recognized phenomenon. EVs are best known as mediators of intercellular communication. However, in a recent issue of Nature, Keller et al. show that they function as decoys to mitigate bacterial toxins. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2020.03.022
更新日期：2020-04-20 00:00:00
abstract：:MEF2 transcription factors are well-established regulators of muscle development. We have discovered an unanticipated role for MEF2C in the neural crest, where tissue-specific inactivation results in neonatal lethality due to severe craniofacial defects. We show that MEF2C is required for expression of the Dlx5, Dlx6,...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.03.007
更新日期：2007-04-01 00:00:00
abstract：:Oncogenic alterations in epithelial tissues often trigger apoptosis, suggesting an evolutionary mechanism by which organisms eliminate aberrant cells from epithelia. In Drosophila imaginal epithelia, clones of cells mutant for tumor suppressors, such as scrib or dlg, lose their polarity and are eliminated by cell deat...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.01.002
更新日期：2009-03-01 00:00:00
abstract：:In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct skeletal stem cell (SSC) commitment and differentiation. However, the mechanisms by which the SSC-ECM interface is regulated and the outcome of such interactions on stem cell fate in vivo remain unknown. Here we demonstrate...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.04.011
更新日期：2013-05-28 00:00:00
abstract：:Positioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.10.009
更新日期：2016-11-07 00:00:00
abstract：:DNA methylation on N6-adenine (6mA) has recently been found to be a potentially epigenetic mark in several unicellular and multicellular eukaryotes. However, its distribution patterns and potential functions in land plants, which are primary producers for most ecosystems, remain largely unknown. Here we report global ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.03.012
更新日期：2018-05-07 00:00:00
abstract：:Epithelial tubes are found in many vital organs and require uniform and correct tube diameters for optimal function. Tube size depends on apical membrane growth and subapical cytoskeletal reorganization, but the cues that coordinate these events to ensure functional tube shape remain elusive. We find that epithelial t...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.07.012
更新日期：2005-09-01 00:00:00
abstract：:In migrating cells, Rho family GTPases and their effectors play a central role in polarizing and in organizing the actin and microtubule cytoskeletons. A study by Fukata et al. in the June 28th issue of Cell now shows that the Rac1/Cdc42 effector IQGAP1 captures microtubules by binding to CLIP170. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章,评审
doi：10.1016/s1534-5807(02)00209-5
更新日期：2002-07-01 00:00:00
abstract：:Pancreatic beta cell proliferation is high at birth and then rapidly declines. In this issue of Developmental Cell,Stolovich-Rain et al. (2015) show that β cells' capacity to increase proliferation in response to injury is unexpectedly not acquired until after weaning-related nutritional changes trigger a metabolic an...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.02.016
更新日期：2015-03-09 00:00:00
abstract：:Exposing cells to folding stress causes a subset of their proteins to misfold and accumulate in inclusion bodies (IBs). IB formation and clearance are both active processes, but little is known about their mechanism. To shed light on this issue, we performed a screen with over 4,000 fluorescently tagged yeast proteins...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.04.015
更新日期：2015-06-08 00:00:00
abstract：:Although it is well established that reactive oxygen species (ROS) can function as intracellular messengers, the mechanism of ROS dependent signaling is largely unknown (Rhee et al.,2005). In a recent paper in Nature Cell Biology, Funato et al. (2006) demonstrate that ROS can modulate signaling by the Wnt/beta-catenin...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2006.05.007
更新日期：2006-06-01 00:00:00
abstract：:T-box genes encode DNA binding transcription factors known to regulate a wide variety of developmental processes during embryogenesis and are present in the genomes of all multicellular animals. Indeed, alongside other more familiar families of developmental regulators such as Hox, Sox, and Pax, T-box genes constitute...
journal_title：Developmental cell
pub_type：
doi：10.1016/s1534-5807(02)00330-1
更新日期：2002-11-01 00:00:00
abstract：:It is intuitive to speculate that nutrient availability may influence differentiation of mammalian cells. Nonetheless, a comprehensive complement of the molecular determinants involved in this process has not been elucidated yet. Here, we have investigated how nutrients (glucose) affect skeletal myogenesis. Glucose re...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.02.004
更新日期：2008-05-01 00:00:00
abstract：:Caspase proteases execute apoptosis but also function in development. In this issue of Developmental Cell, Weaver et al. report that C. elegans CED-3 caspase promotes animal growth through PMK-1/p38 kinase cleavage, and at the expense of pathogen and stress immunity, revealing an unexpected homeostatic relationship be...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2020.04.006
更新日期：2020-05-04 00:00:00
abstract：:Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype ga...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2017.09.020
更新日期：2017-10-09 00:00:00
abstract：:Wnt/β-catenin signaling plays critical roles during embryogenesis, tissue homeostasis, and regeneration. How Wnt-receptor complex activity is regulated is not yet fully understood. Here, we identify the Ly6 family protein LY6/PLAUR domain-containing 6 (Lypd6) as a positive feedback regulator of Wnt/β-catenin signaling...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.07.020
更新日期：2013-08-26 00:00:00
abstract：:Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.07.012
更新日期：2012-09-11 00:00:00
abstract：:RhoA stimulates cell contractility by recruiting downstream effectors to the cortical plasma membrane. We now show that direct binding by anillin is required for effective signaling: this antagonizes the otherwise labile membrane association of GTP-RhoA to promote effector recruitment. However, since its binding to Rh...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.04.031
更新日期：2019-06-17 00:00:00
abstract：:The identities of the ubiquitin-ligases active during myogenesis are largely unknown. Here we describe a RING-type E3 ligase complex specified by the adaptor protein, Ozz, a novel SOCS protein that is developmentally regulated and expressed exclusively in striated muscle. In mice, the absence of Ozz results in overt m...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(04)00020-6
更新日期：2004-02-01 00:00:00
abstract：:In yeast and animal cells, the sterol composition of membranes is a key factor that controls the polarity of membrane proteins by regulating their intracellular trafficking or lateral diffusion. A recent study in Nature Cell Biology demonstrates that plant sterols play a major role in the acquisition of cell polarity ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.02.007
更新日期：2008-03-01 00:00:00
abstract：:Plants assemble beneficial root-associated microbiomes to support growth, especially in nutrient-poor conditions. To do so, however, plants have to suppress their immune system. Reporting in Nature, Castrillo et al. (2017) identified PHOSPHATE STARVATION RESPONSE1 (PHR1) as a central regulator in this balance between ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2017.03.019
更新日期：2017-04-10 00:00:00
abstract：:To ensure equal chromosome segregation during mitosis, the macromolecular kinetochore must remain attached to depolymerizing microtubules, which drive chromosome movements. How kinetochores associate with depolymerizing microtubules, which undergo dramatic structural changes forming curved protofilaments, has yet to b...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.09.012
更新日期：2012-11-13 00:00:00
abstract：:Adult neurogenic niches are present in both vertebrates and invertebrates. Where do stem cells populating these niches originate, and what are the mechanisms maintaining their self-renewal? In this issue of Developmental Cell, Benton et al. (2014) show that in crayfish, hemolymph-derived cells enter a neurogenic niche...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2014.07.024
更新日期：2014-08-11 00:00:00
abstract：:Reconstructing the lineage of cells is central to understanding development and is now also an important issue in stem cell research. Technological advances in genetically engineered permanent cell labeling, together with a multiplicity of fluorescent markers and sophisticated imaging, open new possibilities for prosp...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.07.019
更新日期：2011-09-13 00:00:00
abstract：:The insulin-like peptide (ILP) family plays key biological roles in the control of body growth. Although the functions of ILPs are well understood, the mechanisms by which organisms sense their nutrient status and thereby control ILP production remain largely unknown. Here, we show that signaling relay and feedback me...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.10.003
更新日期：2015-11-09 00:00:00
abstract：:Cytoplasmic dynein-1 is a minus-end-directed motor protein that transports cargo over long distances and organizes the intracellular microtubule (MT) network. How dynein motor activity is harnessed for these diverse functions remains unknown. Here, we have uncovered a mechanism for how processive dynein-dynactin compl...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.12.023
更新日期：2018-01-22 00:00:00
abstract：:Numerous signals drive the proliferative expansion of the distal endoderm and the underlying mesenchyme during lung branching morphogenesis, but little is known about how these signals are integrated. Here, we show by analysis of conditional double mutants that the two T-box transcription factor genes Tbx2 and Tbx3 ac...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.08.007
更新日期：2016-10-24 00:00:00
