Abstract：
:In migrating cells, Rho family GTPases and their effectors play a central role in polarizing and in organizing the actin and microtubule cytoskeletons. A study by Fukata et al. in the June 28th issue of Cell now shows that the Rac1/Cdc42 effector IQGAP1 captures microtubules by binding to CLIP170.
journal_name
Dev Celljournal_title
Developmental cellauthors
Brunner Ddoi
10.1016/s1534-5807(02)00209-5keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
2-4issue
1eissn
1534-5807issn
1878-1551pii
S1534-5807(02)00209-5journal_volume
3pub_type
评论,杂志文章,评审abstract：:Cytoplasmic dynein-1 is a minus-end-directed motor protein that transports cargo over long distances and organizes the intracellular microtubule (MT) network. How dynein motor activity is harnessed for these diverse functions remains unknown. Here, we have uncovered a mechanism for how processive dynein-dynactin compl...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.12.023
更新日期：2018-01-22 00:00:00
abstract：:Sox2 expression marks neural and sensory primordia at various stages of development. A 50 kb genomic region of chicken Sox2 was isolated and scanned for enhancer activity utilizing embryo electroporation, resulting in identification of a battery of enhancers. Although Sox2 expression in the early embryonic CNS appears...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00088-1
更新日期：2003-04-01 00:00:00
abstract：:Gap junctions are present in most tissues and play essential roles in various biological processes. However, we know surprisingly little about the molecular mechanisms underlying gap junction formation. Here, we uncover the essential role of a conserved EGF- and laminin-G-domain-containing protein nlr-1/CASPR in the r...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.10.020
更新日期：2020-12-07 00:00:00
abstract：:Netrin-1 was recently proposed to play an important role in embryonic and pathological angiogenesis. However, data reported led to the apparently contradictory conclusions that netrin-1 is either a pro- or an antiangiogenic factor. Here, we reconcile these opposing observations by demonstrating that netrin-1 acts as a...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.02.006
更新日期：2009-04-01 00:00:00
abstract：:Rab GTPases define the vesicle trafficking pathways underpinning cell polarization and migration. Here, we find that Rab4, Rab11, and Rab14 and the candidate Rab GDP-GTP exchange factors (GEFs) FAM116A and AVL9 are required for cell migration. Rab14 and its GEF FAM116A localize to and act on an intermediate compartmen...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.04.010
更新日期：2012-05-15 00:00:00
abstract：:The combination of fluid and mechanical properties exhibited by cell membranes enables a wealth of physical phenomena, many of which also have biological functions. A recent study in Cell (Shi et al., 2018) now shows that membrane tension in the cell may not be as simple as it first seemed. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.12.011
更新日期：2019-01-07 00:00:00
abstract：:The extracellular matrix (ECM) plays a major role in cancer progression through its increased deposition and alignment. In this issue of Developmental Cell, Fattet et al. reveal a pathway in which ECM stiffness promotes EPHA2/LYN complex activation, leading to TWIST1 nuclear localization and triggering EMT in breast c...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2020.06.032
更新日期：2020-08-10 00:00:00
abstract：:Small repeat-associated siRNAs (rasiRNAs) mediate silencing of retrotransposons and the Stellate locus. Mutations in the Drosophila rasiRNA pathway genes armitage and aubergine disrupt embryonic axis specification, triggering defects in microtubule polarization as well as asymmetric localization of mRNA and protein de...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.12.001
更新日期：2007-01-01 00:00:00
abstract：:How metabolism is rewired during embryonic development is still largely unknown, as it remains a major technical challenge to resolve metabolic activities or metabolite levels with spatiotemporal resolution. Here, we investigated metabolic changes during development of organogenesis-stage mouse embryos, focusing on th...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.01.015
更新日期：2017-02-27 00:00:00
abstract：:Metastasizing breast carcinoma cells have been hypothesized to mobilize tissue-invasive activity by co-opting the proteolytic systems employed by normal mammary epithelial cells undergoing branching morphogenesis. However, the critical effectors underlying morphogenesis remain unidentified, and their relationship to b...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.08.025
更新日期：2018-10-22 00:00:00
abstract：:The epidermis of aerial plant organs is thought to be limiting for growth, because it acts as a continuous load-bearing layer, resisting tension. Leaf epidermis contains jigsaw puzzle piece-shaped pavement cells whose shape has been proposed to be a result of subcellular variations in expansion rate that induce local ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.10.017
更新日期：2017-11-06 00:00:00
abstract：:Migrating cells reorganize their actin and microtubule cytoskeletons in response to external cues. In this issue of Developmental Cell, Watanabe et al. now show a molecular connection between the actin crosslinking protein IQGAP1 and the microtubule-stabilizing protein APC that impacts cells' ability to migrate into a...
journal_title：Developmental cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.devcel.2004.11.012
更新日期：2004-12-01 00:00:00
abstract：:Presenilins are components of the gamma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch proteins. A C. elegans genetic screen revealed two genes, aph-1 and pen-2, encoding multipass transmembrane proteins, that interact strongly with sel-12/presenilin and aph-2/nicastrin. Human ap...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00189-2
更新日期：2002-07-01 00:00:00
abstract：:Centromeres are essential for accurate chromosome segregation and are marked by centromere protein A (CENP-A) nucleosomes. Mis-targeted CENP-A chromatin has been shown to seed centromeres at non-centromeric DNA. However, the requirements for such de novo centromere formation and transmission in vivo remain unknown. He...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.01.005
更新日期：2020-02-10 00:00:00
abstract：:Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype ga...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2017.09.020
更新日期：2017-10-09 00:00:00
abstract：:The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.07.013
更新日期：2005-09-01 00:00:00
abstract：:High-molecular-weight hyaluronan, a major component of the extracellular matrix, is anti-oncogenic, whereas low-molecular-weight hyaluronan is pro-oncogenic, though the mechanisms underlying the size-dependent opposite bioactivities of hyaluronan remain uncertain. We show here that treatment with high-molecular-weight...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.04.018
更新日期：2019-05-20 00:00:00
abstract：:Cell polarity plays a key role in the development of the central nervous system (CNS). Interestingly, disruption of cell polarity is seen in many cancers. ASPP2 is a haplo-insufficient tumor suppressor and an activator of the p53 family. In this study, we show that ASPP2 controls the polarity and proliferation of neur...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.06.003
更新日期：2010-07-20 00:00:00
abstract：:Elucidating chromatin's 3D shape is critical to understanding its function, but the fine structure of chromatin domains remains poorly resolved. In a recent report in Nature, Boettiger et al. (2016) visualize chromatin in super-resolution, gaining unprecedented insight into chromatin architecture. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2016.02.002
更新日期：2016-02-22 00:00:00
abstract：:How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migr...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2021.01.002
更新日期：2021-01-25 00:00:00
abstract：:Developmental growth requires coordination between the growth rates of individual tissues and organs. Here, we examine how Drosophila neuromuscular synapses grow to match the size of their target muscles. We show that changes in muscle growth driven by autonomous modulation of insulin receptor signaling produce corres...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.05.015
更新日期：2020-07-06 00:00:00
abstract：:The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR) complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent years. It has become increasingly evident that these regulatory circuits control some of the most fundamental aspects of metabolism, c...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2007.03.020
更新日期：2007-04-01 00:00:00
abstract：:The Cubitus interruptus (Ci)/Gli family of transcription factors can be degraded either completely or partially from a full-length form (Ci155/Gli(FL)) to a truncated repressor (Ci75/Gli(R)) by proteasomes to mediate Hedgehog (Hh) signaling. The mechanism by which proteasomes distinguish ubiquitinated Ci/Gli to carry ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.05.006
更新日期：2013-06-24 00:00:00
abstract：:We use the Dpp morphogen gradient in the Drosophila wing disc as a model to address the fundamental question of how a gradient of a growth factor can produce uniform growth. We first show that proper expression and subcellular localization of components in the Fat tumor-suppressor pathway, which have been argued to de...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.11.007
更新日期：2011-01-18 00:00:00
abstract：:Reporting in Cell, Berg et al. (2016) reveal a connection between genetic lysosomal storage disorders and the ability of macrophages to migrate and control mycobacterial infection. This insight, resulting from a zebrafish genetic screen, inspired the authors to propose an explanation for the increased susceptibility o...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2016.04.004
更新日期：2016-04-18 00:00:00
abstract：:How adherens junctions (AJs) are formed upon cell division is largely unexplored. Here, we found that AJ formation is coordinated with cytokinesis and relies on an interplay between the dividing cell and its neighbors. During contraction of the cytokinetic ring, the neighboring cells locally accumulate Myosin II and p...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.11.019
更新日期：2013-02-11 00:00:00
abstract：:The extensive subcellular network of membrane contact sites plays central roles in organelle biogenesis and communication, yet the precise contributions of the involved machineries remain largely enigmatic. The yeast vacuole forms a membrane contact site with mitochondria, called vacuolar and mitochondrial patch (vCLA...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.05.011
更新日期：2018-06-04 00:00:00
abstract：:Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-threonine kinase domain. Here, we find that Trpm7-/- T cells are deficient in Fas-receptor-induced apoptosis and that TRPM7 channel activity participates in the apoptotic process and is regulated by caspa...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.04.006
更新日期：2012-06-12 00:00:00
abstract：:We have used Drosophila ovarian follicle stem cells (FSCs) to study how stem cells are regulated by external signals and draw three main conclusions. First, the spatial definition of supportive niche positions for FSCs depends on gradients of Hh and JAK-STAT pathway ligands, which emanate from opposite, distant sites....
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.09.010
更新日期：2012-10-16 00:00:00
abstract：:Centrosomes are important cell organizers. They consist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically during mitosis-a process termed centrosome maturation. How centrosomes mature remains mysterious. Here, we identify a domain in Drosophila Cnn that appears to be phospho...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.02.013
更新日期：2014-03-31 00:00:00
