Abstract:
:The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR) complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent years. It has become increasingly evident that these regulatory circuits control some of the most fundamental aspects of metabolism, cell growth, proliferation, survival, and differentiation at both the cellular and organismal levels. As such, they also play a pivotal role in the genesis of diseases including cancer, diabetes, aging, and degenerative diseases. This review highlights recent developments aimed at deciphering the interplay between Akt and mTORCs as well as their role in embryonic development and in cancer.
journal_name
Dev Celljournal_title
Developmental cellauthors
Bhaskar PT,Hay Ndoi
10.1016/j.devcel.2007.03.020subject
Has Abstractpub_date
2007-04-01 00:00:00pages
487-502issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(07)00120-7journal_volume
12pub_type
杂志文章,评审abstract::The mechanism responsible for subdividing the embryo into individual tissues is a fundamental, yet still poorly understood, question in developmental biology. Various general hypotheses have been proposed, involving differences in cell adhesion, contractility, or contact-mediated repulsion. However, the key parameter ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.09.004
更新日期:2013-10-14 00:00:00
abstract::Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/s1534-5807(01)00098-3
更新日期:2002-01-01 00:00:00
abstract::p120-catenin is an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. Despite recent advances in understanding the roles that p120-catenin and Kaiso play in downstream modulation of Wnt/beta-catenin signaling, the identity of t...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.09.022
更新日期:2006-11-01 00:00:00
abstract::The Par polarity complex creates mutually exclusive cortical domains in diverse animal cells. Activity of the atypical protein kinase C (aPKC) is a key output of the Par complex as phosphorylation removes substrates from the Par domain. Here, we investigate how diverse, apparently unrelated Par substrates couple phosp...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.09.016
更新日期:2015-10-26 00:00:00
abstract::The chemokine CXCL12 and its receptor CXCR4 have many functions during embryonic and post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling in cardiac development and found that embryonic Cxcl12-null hearts lacked intra-ventricular coronary arteries (CAs) and exhibited absent or mispl...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.03.026
更新日期:2015-05-26 00:00:00
abstract::Small GTPase Cdc42 triggers polarity establishment in budding yeast. In this issue of Developmental Cell, Okada et al. (2013) combine in silico modeling and cell biology to show that Cdc42, septins, and the exocytosis pathway are integrated in a feedback system to define and insulate the site of polarity in the membra...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2013.07.004
更新日期:2013-07-29 00:00:00
abstract::All complex multicellular organisms must solve the problem of generating diverse and appropriately patterned cell types. Asymmetric division, in which a single mother cell gives rise to daughters with distinct identities, is instrumental in the generation of cellular diversity and higher-level patterns. In animal syst...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2009.05.014
更新日期:2009-06-01 00:00:00
abstract::Centromeres form the site of chromosome attachment to microtubules during mitosis. Identity of these loci is maintained epigenetically by nucleosomes containing the histone H3 variant CENP-A. Propagation of CENP-A chromatin is uncoupled from DNA replication initiating only during mitotic exit. We now demonstrate that ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.10.014
更新日期:2012-01-17 00:00:00
abstract::Regulating the osmotic pressure of our body fluids relies on osmosensory neurons that depolarize when their volume decreases. Recently in Neuron, Prager-Khoutorsky et al. (2014) report that this depolarization arises from direct interactions between the transient receptor potential channel TRPV1 and microtubules, whic...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2014.08.012
更新日期:2014-08-25 00:00:00
abstract::The TGF-beta family member Nodal is one of the most potent molecules known to an embryo. Studies on Nodal regulation thus far have focused on its transcription, maturation, and interaction with antagonists. Two recent studies on the role of microRNAs (miRNAs) in Nodal signaling now reveal that something important was ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2007.09.012
更新日期:2007-10-01 00:00:00
abstract::Morphogenesis of wavy epidermal pavement cells in plants has fascinated researchers for decades. A mechanical mechanism had been proposed in which the anticlinal cell walls, forming the in-plane cell borders, feature contiguous stiff and soft zones that generate waves upon stretching. We replicated this model as desig...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2019.05.001
更新日期:2019-07-01 00:00:00
abstract::Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However, spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging. Here, we developed an optimized protocol for single-molecule transcript imaging in the intact pancreas and used it to identify a sub-po...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.11.001
更新日期:2019-01-07 00:00:00
abstract::Growth and development are coordinated by an array of intercellular communications. Known plant signaling molecules include phytohormones and hormone peptides. Although both classes can be implicated in the same developmental processes, little is known about the interplay between phytohormone action and peptide signal...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.02.002
更新日期:2012-03-13 00:00:00
abstract::The anterior visceral endoderm plays a pivotal role in establishing anterior-posterior polarity of the mouse embryo, but the molecular nature of the signals required remains to be determined. Here, we demonstrate that Cerberus-like(-/-);Lefty1(-/-) compound mutants can develop a primitive streak ectopically in the emb...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00321-0
更新日期:2002-11-01 00:00:00
abstract::Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the bloodstream, reach distant organs, and locally modify the microenvironment. However, visualizing these events in vivo still faces major hurdles. Here...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.01.014
更新日期:2019-02-25 00:00:00
abstract::The myogenic regulatory genes Myf5, Mrf4, Myod, and Myogenin likely arose by gene duplications during evolution, presumably to address the more demanding requirements of the vertebrate body plan. Two cell lineages were proposed to be regulated independently by Myf5 and Myod to safeguard against tissue failure. Here we...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.11.005
更新日期:2014-12-08 00:00:00
abstract::Understanding the mechanisms driving tissue and organ formation requires knowledge across scales. How do signaling pathways specify distinct tissue types? How does the patterning system control morphogenesis? How do these processes evolve? The Drosophila egg chamber, where EGF and BMP signaling intersect to specify un...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2017.02.018
更新日期:2017-05-22 00:00:00
abstract::Rab GTPases define the vesicle trafficking pathways underpinning cell polarization and migration. Here, we find that Rab4, Rab11, and Rab14 and the candidate Rab GDP-GTP exchange factors (GEFs) FAM116A and AVL9 are required for cell migration. Rab14 and its GEF FAM116A localize to and act on an intermediate compartmen...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.04.010
更新日期:2012-05-15 00:00:00
abstract::Cytokinins affect plant immunity to various pathogens; however, the mechanisms coupling plant-derived cytokinins to pathogen responses have been elusive. Here, we found that plant-derived cytokinins promote resistance of Arabidopsis to Pseudomonas syringae pv. tomato DC3000 (Pst). Modulated cytokinin levels or signali...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.07.011
更新日期:2010-08-17 00:00:00
abstract::The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney deve...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.04.012
更新日期:2015-05-04 00:00:00
abstract::The Drosophila gene neuralized (neur) has long been recognized to be essential for the proper execution of a wide variety of processes mediated by the Notch (N) pathway, but its role in the pathway has been elusive. In this report, we present genetic and biochemical evidence that Neur is a RING-type, E3 ubiquitin liga...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(01)00092-2
更新日期:2001-12-01 00:00:00
abstract::The binding of Hedgehog (Hh) to its receptor Patched causes derepression of Smoothened (Smo), resulting in the activation of the Hh pathway. Here, we show that Smo activation is dependent on the levels of the phospholipid phosphatidylinositol-4 phosphate (PI4P). Loss of STT4 kinase, which is required for the generatio...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.06.007
更新日期:2010-07-20 00:00:00
abstract::To enable stratification and barrier function, the epidermis must permit self-renewal while maintaining adhesive connections. By generating K14-GFP-actin mice to monitor actin dynamics in cultured primary keratinocytes, we uncovered a role for the actin cytoskeleton in establishing cellular organization. During epider...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00259-9
更新日期:2002-09-01 00:00:00
abstract::In this issue of Developmental Cell, Chakraborty et al. report that efficient advancement through G1/S phase requires the downregulation of Nup96 levels during M phase. The authors show that oscillations in Nup96 levels plays a key role in maintaining normal cell proliferation, likely by regulating the export of speci...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2008.10.010
更新日期:2008-11-01 00:00:00
abstract::Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-threonine kinase domain. Here, we find that Trpm7-/- T cells are deficient in Fas-receptor-induced apoptosis and that TRPM7 channel activity participates in the apoptotic process and is regulated by caspa...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.04.006
更新日期:2012-06-12 00:00:00
abstract::Although we know that mesenchymal progenitors give rise to nephrons in the kidney, how they balance self-renewal versus differentiation is still unclear. In this issue of Developmental Cell, Chen et al. (2015) show that nephron progenitors age, but not necessarily irreversibly: old progenitors can be "rejuvenated" by ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.09.023
更新日期:2015-10-12 00:00:00
abstract::Although it is well established that reactive oxygen species (ROS) can function as intracellular messengers, the mechanism of ROS dependent signaling is largely unknown (Rhee et al.,2005). In a recent paper in Nature Cell Biology, Funato et al. (2006) demonstrate that ROS can modulate signaling by the Wnt/beta-catenin...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2006.05.007
更新日期:2006-06-01 00:00:00
abstract::Sister chromatids are held together by the cohesin complex from the time they are made until cell division. In recent articles published in Cell and Current Biology, the characterization of Wapl, a newly identified cohesin-interacting protein, suggests that a dynamic interaction between the cohesin complex and chromat...
journal_title:Developmental cell
pub_type: 社论
doi:10.1016/j.devcel.2006.11.010
更新日期:2006-12-01 00:00:00
abstract::Macropinocytosis coordinates non-specific uptake of macromolecules and fluid. Cancers employ macropinocytosis to obtain nutrients to support their metabolic homeostasis. In this issue of Developmental Cell, Lee et al. (2019) report that glutamine deprivation boosts macropinocytosis via EGFR signaling induction, provid...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2019.07.020
更新日期:2019-08-05 00:00:00
abstract::Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2017.10.001
更新日期:2017-11-20 00:00:00