Abstract:
:Regulating the osmotic pressure of our body fluids relies on osmosensory neurons that depolarize when their volume decreases. Recently in Neuron, Prager-Khoutorsky et al. (2014) report that this depolarization arises from direct interactions between the transient receptor potential channel TRPV1 and microtubules, which seem to directly push open the channel.
journal_name
Dev Celljournal_title
Developmental cellauthors
Andrés M,Göpfert MCdoi
10.1016/j.devcel.2014.08.012subject
Has Abstractpub_date
2014-08-25 00:00:00pages
363-4issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(14)00522-Xjournal_volume
30pub_type
评论,杂志文章abstract::The cytoplasm is not a homogenous solution but instead consists of large dynamic assemblies that arise from transient molecular interactions. Some of these structures have been shown to represent liquid droplets of concentrated protein and RNA. Liquid phase separation of cytoplasm may be a fundamental principle of cyt...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.06.013
更新日期:2011-07-19 00:00:00
abstract::Local translation allows spatial control of gene expression. Here, we performed a dual protein-mRNA localization screen, using smFISH on 523 human cell lines expressing GFP-tagged genes. 32 mRNAs displayed specific cytoplasmic localizations with local translation at unexpected locations, including cytoplasmic protrusi...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.07.010
更新日期:2020-09-28 00:00:00
abstract::Germ cells, the cells that give rise to sperm and egg, maintain the potential to recreate all cell types in a new individual. This wide developmental potential, or totipotency, is manifested in unusual tumors called teratomas, in which germ cells undergo somatic differentiation. Although recent studies have implicated...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2009.08.003
更新日期:2009-09-01 00:00:00
abstract::Vertebrate gastrulation requires coordination of mesoderm specification with morphogenetic movements. While both of these processes require FGF signaling, it is not known how mesoderm specification and cell movements are coordinated during gastrulation. The related Sprouty and Spred protein families are recently disco...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.02.011
更新日期:2005-05-01 00:00:00
abstract::The gastrulating vertebrate embryo develops three germlayers: ectoderm, mesoderm, and endoderm. Zebrafish endoderm differentiation starts with the activation of sox17 by casanova (cas). We report that spg (pou2/Oct4) is essential for endoderm formation. Embryos devoid of maternal and zygotic spg function (MZspg) lack ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00396-4
更新日期:2004-01-01 00:00:00
abstract::Hox proteins gain specificity by interacting with TALE-class cofactors. In a recent issue of Cell and in this issue of Developmental Cell, Crocker et al. (2015) and Amin et al. (2015), respectively, demonstrate that non-canonical Hox/TALE binding sequences play a major role in the regionalized regulation of target gen...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.01.030
更新日期:2015-02-09 00:00:00
abstract::One G protein-coupled receptor (GPCR) can activate more than one G protein, but the physiologic importance of such activation has not been demonstrated in vivo. We have generated mice expressing exclusively a mutant form of the PTH/PTHrP receptor (DSEL) that activates adenylyl cyclase normally but not phospholipase C ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00218-6
更新日期:2002-08-01 00:00:00
abstract::Dynamin family members are large GTPases that assemble into multimeric spirals. These spirals promote membrane fission or fusion, or they inhibit processes such as viral replication. Two new studies by Chappie et al. and Gao et al. in a recent issue of Nature identify interactions between subunits of dynamin spirals, ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.05.001
更新日期:2010-05-18 00:00:00
abstract::The binding of Hedgehog (Hh) to its receptor Patched causes derepression of Smoothened (Smo), resulting in the activation of the Hh pathway. Here, we show that Smo activation is dependent on the levels of the phospholipid phosphatidylinositol-4 phosphate (PI4P). Loss of STT4 kinase, which is required for the generatio...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.06.007
更新日期:2010-07-20 00:00:00
abstract::Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the E...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2011.05.015
更新日期:2011-07-19 00:00:00
abstract::Recently, there has been a surge in the number of pioneering studies combining experiments with quantitative modeling to explain both relatively simple modules of molecular machinery of the cell and to achieve system-level understanding of cellular networks. Here we discuss the utility and methods of modeling and revi...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2006.08.004
更新日期:2006-09-01 00:00:00
abstract::Airway smooth muscle is best known for its role as an airway constrictor in diseases such as asthma. However, its function in lung development is debated. A prevalent model, supported by in vitro data, posits that airway smooth muscle promotes lung branching through peristalsis and pushing intraluminal fluid to branch...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.02.001
更新日期:2020-04-06 00:00:00
abstract::Bacteria display an array of contact-dependent interaction systems that have evolved to facilitate direct cell-to-cell communication. We have previously identified a mode of bacterial communication mediated by nanotubes bridging neighboring cells. Here, we elucidate nanotube architecture, dynamics, and molecular compo...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.01.013
更新日期:2016-02-22 00:00:00
abstract::We studied the role of the target of rapamycin complex 2 (mTORC2) during neutrophil chemotaxis, a process that is mediated through the polarization of actin and myosin filament networks. We show that inhibition of mTORC2 activity, achieved via knock down (KD) of Rictor, severely inhibits neutrophil polarization and di...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.11.004
更新日期:2010-12-14 00:00:00
abstract::Precise cell division control is critical for developmental patterning. For the differentiation of a functional stoma, a cellular valve for efficient gas exchange, the single symmetric division of an immediate precursor is absolutely essential. Yet, the mechanism governing this event remains unclear. Here we report co...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.04.010
更新日期:2018-05-07 00:00:00
abstract::Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the adipogenic fate of FAPs in injured and diseased muscle by restraining Hedgehog signaling. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2017.06.023
更新日期:2017-07-24 00:00:00
abstract::CLASPs are mammalian microtubule-stabilizing proteins that can mediate the interaction between distal microtubule ends and the cell cortex. Using mass spectrometry-based assays, we have identified two CLASP partners, LL5beta and ELKS. LL5beta and ELKS form a complex that colocalizes with CLASPs at the cortex of HeLa c...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.05.012
更新日期:2006-07-01 00:00:00
abstract::Messenger RNAs (mRNAs) are synthesized in the cell nucleus and transported through nuclear pores to the cytoplasm for protein synthesis. Reporting in Nature Cell Biology, Mor et al. now track in living cells in real time the journey of single mRNA molecules as they transit from nucleus to cytoplasm. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2010.05.021
更新日期:2010-06-15 00:00:00
abstract::Understanding cells as integrated systems requires that we systematically decipher how single genes affect multiple biological processes and how processes are functionally linked. Here, we used multiprocess phenotypic profiling, combining high-resolution 3D confocal microscopy and multiparametric image analysis, to si...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.09.005
更新日期:2014-10-27 00:00:00
abstract::By functioning as an enzyme cofactor, hemoglobin component, and gene regulator, heme is vital for life. One mode of heme-regulated transcription involves amplifying the activity of GATA-1, a key determinant of erythrocyte differentiation. To discover biological consequences of the metal cofactor-transcription factor m...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.07.022
更新日期:2018-09-10 00:00:00
abstract::Endoplasmic reticulum-plasma membrane (ER-PM) junctions are conserved structures defined as regions of the ER that tightly associate with the plasma membrane. However, little is known about the mechanisms that tether these organelles together and why such connections are maintained. Using a quantitative proteomic appr...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.11.004
更新日期:2012-12-11 00:00:00
abstract::In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2019.05.030
更新日期:2019-06-03 00:00:00
abstract::Phase separation represents an important form of subcellular compartmentalization. However, relatively little is known about how the formation or disassembly of such compartments is regulated. In zebrafish, the Balbiani body (Bb) and the germ plasm (Gp) are intimately linked phase-separated structures essential for ge...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.07.009
更新日期:2018-08-06 00:00:00
abstract::All complex multicellular organisms must solve the problem of generating diverse and appropriately patterned cell types. Asymmetric division, in which a single mother cell gives rise to daughters with distinct identities, is instrumental in the generation of cellular diversity and higher-level patterns. In animal syst...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2009.05.014
更新日期:2009-06-01 00:00:00
abstract::Polarized delivery of signaling and adhesion molecules to the leading edge is required for directional migration of cells. Here, we describe a role for the PIP(2)-synthesizing enzyme, PIPKIγi2, in regulation of exocyst complex control of cell polarity and polarized integrin trafficking during migration. Loss of PIPKIγ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.10.030
更新日期:2012-01-17 00:00:00
abstract::Centrosomes are important cell organizers. They consist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically during mitosis-a process termed centrosome maturation. How centrosomes mature remains mysterious. Here, we identify a domain in Drosophila Cnn that appears to be phospho...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.02.013
更新日期:2014-03-31 00:00:00
abstract::Cell constriction promotes epithelial sheet invagination during embryogenesis across phyla. However, how this cell response is linked to global patterning information during organogenesis remains unclear. To address this issue, we have used the Drosophila eye and studied the formation of the morphogenetic furrow (MF),...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2007.09.015
更新日期:2007-11-01 00:00:00
abstract::The actin remodeling factor N-WASP is best known as an Arp2/3 complex activator in processes like endocytosis, extracellular matrix degradation, and host-pathogen interaction. In this issue of Developmental Cell, Juin et al. establish a novel trafficking function for N-WASP in driving lysophosphatidic acid-dependent c...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2019.10.029
更新日期:2019-11-18 00:00:00
abstract::Many human genes generate mRNAs with alternative 3' untranslated regions (3' UTRs), which can modulate protein function. In a recent Cell paper, Ma and Mayr (2018) unveil a major membraneless organelle, termed the TIS granule-endoplasmic reticulum (TIGER), which enables specific 3' UTRs to encipher protein localizatio...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2018.11.022
更新日期:2018-12-03 00:00:00
abstract::Yeast cells track gradients of pheromones to locate mating partners. Intuition suggests that uniform distribution of pheromone receptors over the cell surface would yield optimal gradient sensing. However, yeast cells display polarized receptors. The benefit of such polarization was unknown. During gradient tracking, ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.10.024
更新日期:2015-11-23 00:00:00