miRNA in embryonic development: the taming of Nodal signaling.

abstract：:hunchback regulates the temporal identity of neuroblasts in Drosophila. Here we show that hbl-1, the C. elegans hunchback ortholog, also controls temporal patterning. Furthermore, hbl-1 is a probable target of microRNA regulation through its 3'UTR. hbl-1 loss-of-function causes the precocious expression of adult seam ...

journal_title：Developmental cell

authors： Lin SY,Johnson SM,Abraham M,Vella MC,Pasquinelli A,Gamberi C,Gottlieb E,Slack FJ

更新日期：2003-05-01 00:00:00

abstract：:Border cells in the Drosophila ovary originate within an epithelium, detach from it, invade neighboring nurse cells, and migrate as a coherent cluster. This migration has served as a useful genetic model for understanding epithelial cell motility. The prevailing model of growth factor-mediated chemotaxis in general, a...

journal_title：Developmental cell

authors： Prasad M,Montell DJ

更新日期：2007-06-01 00:00:00

abstract：:TC10, a Rho family GTPase, has been shown to play an important role in the exocytosis of GLUT4 and other proteins, primarily by tethering the vesicles at the plasma membrane. Using a newly developed probe based on fluorescence resonance energy transfer, we found that TC10 activity at tethered vesicles dropped immediat...

journal_title：Developmental cell

authors： Kawase K,Nakamura T,Takaya A,Aoki K,Namikawa K,Kiyama H,Inagaki S,Takemoto H,Saltiel AR,Matsuda M

更新日期：2006-09-01 00:00:00

abstract：:Processing bodies (P bodies) are discrete cytoplasmic foci to which mRNA is routed for degradation. In mammalian cells, they are also associated with miRNA-induced translational silencing and siRNA-induced mRNA degradation. In a recent issue of Molecular Cell, Ding and coworkers described an argonaute-interacting prot...

journal_title：Developmental cell

authors： Anderson P

更新日期：2005-09-01 00:00:00

abstract：:Enhancers are the primary determinants of cell identity, but the regulatory components controlling enhancer turnover during lineage commitment remain largely unknown. Here we compare the enhancer landscape, transcriptional factor occupancy, and transcriptomic changes in human fetal and adult hematopoietic stem/progeni...

journal_title：Developmental cell

authors： Huang J,Liu X,Li D,Shao Z,Cao H,Zhang Y,Trompouki E,Bowman TV,Zon LI,Yuan GC,Orkin SH,Xu J

更新日期：2016-01-11 00:00:00

abstract：:Pericytes are critical for cerebrovascular maturation and development of the blood-brain barrier (BBB), but their role in maintenance of the adult BBB, and how CNS pericytes differ from those of other tissues, is less well understood. We show that the forkhead transcription factor Foxf2 is specifically expressed in pe...

journal_title：Developmental cell

authors： Reyahi A,Nik AM,Ghiami M,Gritli-Linde A,Pontén F,Johansson BR,Carlsson P

更新日期：2015-07-06 00:00:00

abstract：:Exposure to environmental teratogenic pollutant leads to severe birth defects. However, the biological events underlying these developmental abnormalities remain undefined. Here, we report a molecular link between an environmental stress response pathway and key developmental genes during craniofacial development. Str...

journal_title：Developmental cell

authors： Zalc A,Rattenbach R,Auradé F,Cadot B,Relaix F

更新日期：2015-04-06 00:00:00

abstract：:We have identified and characterized a novel C. elegans gene, ced-12, that functions in the conserved GTPase signaling pathway mediated by CED-2/Crkll, CED-5/DOCK180, and CED-10/Rac to control cell migration and phagocytosis of apoptotic cells. We provide evidence that ced-12 likely acts upstream of ced-10 during cell...

journal_title：Developmental cell

authors： Wu YC,Tsai MC,Cheng LC,Chou CJ,Weng NY

更新日期：2001-10-01 00:00:00

abstract：:Zebrafish is a powerful model for forward genetics. Reverse genetic approaches are limited by the time required to generate stable mutant lines. We describe a system for gene knockout that consistently produces null phenotypes in G0 zebrafish. Yolk injection of sets of four CRISPR/Cas9 ribonucleoprotein complexes redu...

journal_title：Developmental cell

authors： Wu RS,Lam II,Clay H,Duong DN,Deo RC,Coughlin SR

更新日期：2018-07-02 00:00:00

abstract：:In this issue of Developmental Cell, Chakraborty et al. report that efficient advancement through G1/S phase requires the downregulation of Nup96 levels during M phase. The authors show that oscillations in Nup96 levels plays a key role in maintaining normal cell proliferation, likely by regulating the export of speci...

journal_title：Developmental cell

authors： Wozniak RW,Goldfarb DS

更新日期：2008-11-01 00:00:00

abstract：:Mammalian neurulation is completed when the dorsolateral neural folds bend inwards, their tips make adhesive contacts across the midline, and the epithelia remodel to create a closed neural tube. Two recent papers (one by Camerer et al. in this issue of Developmental Cell) demonstrate a vital role for protease-activat...

journal_title：Developmental cell

authors： Copp AJ,Greene ND

更新日期：2010-01-19 00:00:00

abstract：:In this issue of Developmental Cell, Isabella and Horne-Badovinac (2016) show that Rab10 directs site-specific secretion of basement membrane components, which assemble into fibrils that spool out to elongate the Drosophila egg chamber. These findings establish the basement membrane's active role in tissue sculpting. ...

journal_title：Developmental cell

authors： Jayadev R,Sherwood DR

更新日期：2016-07-11 00:00:00

abstract：:To maintain mechanical homeostasis, cells must recognize and respond to changes in cytoskeletal integrity. By imaging live cells expressing fluorescently tagged cytoskeletal proteins, we observed that actin stress fibers undergo local, acute, force-induced elongation and thinning events that compromise their stress tr...

journal_title：Developmental cell

authors： Smith MA,Blankman E,Gardel ML,Luettjohann L,Waterman CM,Beckerle MC

更新日期：2010-09-14 00:00:00

abstract：:All pancreatic endocrine cells, producing glucagon, insulin, somatostatin, or PP, differentiate from Pdx1+ progenitors that transiently express Neurogenin3. To understand whether the competence of pancreatic progenitors changes over time, we generated transgenic mice expressing a tamoxifen-inducible Ngn3 fusion protei...

journal_title：Developmental cell

authors： Johansson KA,Dursun U,Jordan N,Gu G,Beermann F,Gradwohl G,Grapin-Botton A

更新日期：2007-03-01 00:00:00

abstract：:Cells entering mitosis become rounded, lose attachment to the substrate, and increase their cortical rigidity. Pivotal to these events is the dismantling of focal adhesions (FAs). How mitotic reshaping is linked to commitment to divide is unclear. Here, we show that DEPDC1B, a protein that accumulates in G2, coordinat...

journal_title：Developmental cell

authors： Marchesi S,Montani F,Deflorian G,D'Antuono R,Cuomo A,Bologna S,Mazzoccoli C,Bonaldi T,Di Fiore PP,Nicassio F

更新日期：2014-11-24 00:00:00

abstract：:The complex muscle patterns of higher organisms arise as migrating myoblasts are guided toward and connect with specific attachment sites. We review here the current understanding of myotube migration, focusing on its dynamic nature and the few molecular cues that have been identified to date. Much of this knowledge c...

journal_title：Developmental cell

authors： Schnorrer F,Dickson BJ

更新日期：2004-07-01 00:00:00

abstract：:Sox2 expression marks neural and sensory primordia at various stages of development. A 50 kb genomic region of chicken Sox2 was isolated and scanned for enhancer activity utilizing embryo electroporation, resulting in identification of a battery of enhancers. Although Sox2 expression in the early embryonic CNS appears...

journal_title：Developmental cell

authors： Uchikawa M,Ishida Y,Takemoto T,Kamachi Y,Kondoh H

更新日期：2003-04-01 00:00:00

abstract：:Epithelial cells acquire mesenchymal characteristics during development, wound healing and inflammation, and in cancer and fibrosis. With increasing appreciation of different roles of epithelial-mesenchymal transition (EMT), we address the question of how to define and recognize EMT processes and discuss their propert...

journal_title：Developmental cell

authors： Derynck R,Weinberg RA

更新日期：2019-05-06 00:00:00

abstract：:Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we ...

journal_title：Developmental cell

authors： Centanin L,Dekanty A,Romero N,Irisarri M,Gorr TA,Wappner P

更新日期：2008-04-01 00:00:00

abstract：:In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...

journal_title：Developmental cell

authors： Long F

更新日期：2019-06-03 00:00:00

abstract：:The frizzled (fz) gene of Drosophila is required for planar polarity establishment in the adult cuticle, acting both cell autonomously and nonautonomously. We demonstrate that these two activities of fz in planar polarity are temporally separable in both the eye and wing. The nonautonomous function is dishevelled (dsh...

journal_title：Developmental cell

authors： Strutt H,Strutt D

更新日期：2002-12-01 00:00:00

abstract：:Novel body structures are often generated by the redeployment of ancestral components of the genome. In this issue of Developmental Cell, Glassford et al. (2015) present a thorough analysis of the co-option of a gene regulatory network in the origin of an evolutionary novelty. ...

journal_title：Developmental cell

authors： Preger-Ben Noon E,Frankel N

更新日期：2015-09-14 00:00:00

abstract：:Centromeres are essential for accurate chromosome segregation and are marked by centromere protein A (CENP-A) nucleosomes. Mis-targeted CENP-A chromatin has been shown to seed centromeres at non-centromeric DNA. However, the requirements for such de novo centromere formation and transmission in vivo remain unknown. He...

journal_title：Developmental cell

authors： Palladino J,Chavan A,Sposato A,Mason TD,Mellone BG

更新日期：2020-02-10 00:00:00

abstract：:Oncogenic alterations in epithelial tissues often trigger apoptosis, suggesting an evolutionary mechanism by which organisms eliminate aberrant cells from epithelia. In Drosophila imaginal epithelia, clones of cells mutant for tumor suppressors, such as scrib or dlg, lose their polarity and are eliminated by cell deat...

journal_title：Developmental cell

authors： Igaki T,Pastor-Pareja JC,Aonuma H,Miura M,Xu T

更新日期：2009-03-01 00:00:00

abstract：:SnoN regulates multiple signaling pathways, including TGF-β/Smad and p53, and displays both pro-oncogenic and anti-oncogenic activities in human cancer. We have observed previously that both its intracellular localization and expression levels are sensitive to cell density, suggesting that it may crosstalk with Hippo ...

journal_title：Developmental cell

authors： Zhu Q,Le Scolan E,Jahchan N,Ji X,Xu A,Luo K

更新日期：2016-06-06 00:00:00

abstract：:The sense organs of the vertebrate head comprise structures as varied as the eye, inner ear, and olfactory epithelium. In the early embryo, these assorted structures share a common developmental origin within the preplacodal region and acquire specific characteristics only later. Here we demonstrate a fundamental simi...

journal_title：Developmental cell

authors： Bailey AP,Bhattacharyya S,Bronner-Fraser M,Streit A

更新日期：2006-10-01 00:00:00

abstract：:During chick gastrulation, inhibition of BMP signaling is required for primitive streak formation and induction of Hensen's node. We have identified a unique secreted protein, Tsukushi (TSK), which belongs to the Small Leucine-Rich Proteoglycan (SLRP) family and is expressed in the primitive streak and Hensen's node. ...

journal_title：Developmental cell

authors： Ohta K,Lupo G,Kuriyama S,Keynes R,Holt CE,Harris WA,Tanaka H,Ohnuma SI

更新日期：2004-09-01 00:00:00

abstract：:Although many features of neurogenesis during development and in the adult are intrinsic to the neurogenic cells themselves, the role of the microenvironment is irrefutable. The neurogenic niche is a melting pot of cells and factors that influence CNS development. How do the diverse elements assemble and when? How doe...

journal_title：Developmental cell

authors： Bjornsson CS,Apostolopoulou M,Tian Y,Temple S

更新日期：2015-02-23 00:00:00

abstract：:Selection of the correct targets for myelination and regulation of myelin sheath growth are essential for central nervous system (CNS) formation and function. Through a genetic screen in zebrafish and complementary analyses in mice, we find that loss of oligodendrocyte Neurofascin leads to mistargeting of myelin to ce...

journal_title：Developmental cell

authors： Klingseisen A,Ristoiu AM,Kegel L,Sherman DL,Rubio-Brotons M,Almeida RG,Koudelka S,Benito-Kwiecinski SK,Poole RJ,Brophy PJ,Lyons DA

更新日期：2019-12-16 00:00:00

abstract：:Morphogenesis of wavy epidermal pavement cells in plants has fascinated researchers for decades. A mechanical mechanism had been proposed in which the anticlinal cell walls, forming the in-plane cell borders, feature contiguous stiff and soft zones that generate waves upon stretching. We replicated this model as desig...

journal_title：Developmental cell

authors： Bidhendi AJ,Geitmann A

更新日期：2019-07-01 00:00:00