Abstract：
:hunchback regulates the temporal identity of neuroblasts in Drosophila. Here we show that hbl-1, the C. elegans hunchback ortholog, also controls temporal patterning. Furthermore, hbl-1 is a probable target of microRNA regulation through its 3'UTR. hbl-1 loss-of-function causes the precocious expression of adult seam cell fates. This phenotype is similar to loss-of-function of lin-41, a known target of the let-7 microRNA. Like lin-41 mutations, hbl-1 loss-of-function partially suppresses a let-7 mutation. The hbl-1 3'UTR is both necessary and sufficient to downregulate a reporter gene during development, and the let-7 and lin-4 microRNAs are both required for HBL-1/GFP downregulation. Multiple elements in the hbl-1 3'UTR show complementarity to regulatory microRNAs, suggesting that microRNAs directly control hbl-1. MicroRNAs may likewise function to regulate Drosophila hunchback during temporal patterning of the nervous system.
journal_name
Dev Celljournal_title
Developmental cellauthors
Lin SY,Johnson SM,Abraham M,Vella MC,Pasquinelli A,Gamberi C,Gottlieb E,Slack FJdoi
10.1016/s1534-5807(03)00124-2keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
639-50issue
5eissn
1534-5807issn
1878-1551pii
S1534-5807(03)00124-2journal_volume
4pub_type
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