Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos.

abstract：:Orientation of cell division is a vital aspect of tissue morphogenesis and growth. Asymmetric divisions generate cell fate diversity and epithelial stratification, whereas symmetric divisions contribute to tissue growth, spreading, and elongation. Here, we describe a mechanism for positioning the spindle in symmetric ...

journal_title：Developmental cell

authors： Woolner S,Papalopulu N

更新日期：2012-04-17 00:00:00

abstract：:The faithful alignment of homologous chromosomes during meiotic prophase requires the coordination of DNA double-strand break (DSB) repair with large-scale chromosome reorganization. Here we identify the phosphatase PP4 (Pph3/Psy2) as a mediator of this process in Saccharomyces cerevisiae. In pp4 mutants, early stages...

journal_title：Developmental cell

authors： Falk JE,Chan AC,Hoffmann E,Hochwagen A

更新日期：2010-10-19 00:00:00

abstract：:Neutrophils are essential to the homeostatic mission of safeguarding host tissues, responding rapidly and diversely to breaches of the host's barriers to infection, and returning tissues to a sterile state. In response to specific stimuli, neutrophils extrude modified chromatin structures decorated with specific cytop...

journal_title：Developmental cell

authors： Sollberger G,Tilley DO,Zychlinsky A

更新日期：2018-03-12 00:00:00

abstract：:While GDNF signaling through the Ret receptor is critical for kidney development, its specific role in branching morphogenesis of the epithelial ureteric bud (UB) is unclear. Ret expression defines a population of UB "tip cells" distinct from cells of the tubular "trunks," but how these cells contribute to UB growth i...

journal_title：Developmental cell

authors： Shakya R,Watanabe T,Costantini F

更新日期：2005-01-01 00:00:00

abstract：:In eukaryotes, small RNAs (sRNAs) have key roles in development, gene expression regulation, and genome integrity maintenance. In ciliates, such as Paramecium, sRNAs form the heart of an epigenetic system that has evolved from core eukaryotic gene silencing components to selectively target DNA for deletion. In Paramec...

journal_title：Developmental cell

authors： Sandoval PY,Swart EC,Arambasic M,Nowacki M

更新日期：2014-01-27 00:00:00

abstract：:The insulin-like peptide (ILP) family plays key biological roles in the control of body growth. Although the functions of ILPs are well understood, the mechanisms by which organisms sense their nutrient status and thereby control ILP production remain largely unknown. Here, we show that signaling relay and feedback me...

journal_title：Developmental cell

authors： Okamoto N,Nishimura T

更新日期：2015-11-09 00:00:00

abstract：:Dynamic rearrangements of the actin cytoskeleton play a key role in numerous cellular processes. In Drosophila, fusion between a muscle founder cell and a fusion competent myoblast (FCM) is mediated by an invasive, F-actin-enriched podosome-like structure (PLS). Here, we show that the dynamics of the PLS is controlled...

journal_title：Developmental cell

authors： Jin P,Duan R,Luo F,Zhang G,Hong SN,Chen EH

更新日期：2011-05-17 00:00:00

abstract：:The Frizzled (Fz) receptor is required cell autonomously in Wnt/beta-catenin and planar cell polarity (PCP) signaling. In addition to these requirements, Fz acts nonautonomously during PCP establishment: wild-type cells surrounding fz(-) patches reorient toward the fz(-) cells. The molecular mechanism(s) of nonautonom...

journal_title：Developmental cell

authors： Wu J,Mlodzik M

更新日期：2008-09-01 00:00:00

abstract：:Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we ...

journal_title：Developmental cell

authors： Centanin L,Dekanty A,Romero N,Irisarri M,Gorr TA,Wappner P

更新日期：2008-04-01 00:00:00

abstract：:Centromeres form the site of chromosome attachment to microtubules during mitosis. Identity of these loci is maintained epigenetically by nucleosomes containing the histone H3 variant CENP-A. Propagation of CENP-A chromatin is uncoupled from DNA replication initiating only during mitotic exit. We now demonstrate that ...

journal_title：Developmental cell

authors： Silva MC,Bodor DL,Stellfox ME,Martins NM,Hochegger H,Foltz DR,Jansen LE

更新日期：2012-01-17 00:00:00

abstract：:Melanocortin 4 receptor (Mc4r) plays a crucial role in the central control of energy homeostasis, but its role in peripheral organs has not been fully explored. We have investigated the roles of hypothalamus-mediated energy metabolism during Xenopus limb regeneration. We report that hypothalamus injury inhibits Xenopu...

journal_title：Developmental cell

authors： Zhang M,Chen Y,Xu H,Yang L,Yuan F,Li L,Xu Y,Chen Y,Zhang C,Lin G

更新日期：2018-08-20 00:00:00

abstract：:We developed a comprehensive dataset that samples the mouse transcriptome every 6 hr, from gastrulation through organogenesis. We observe an abrupt increase in overall transcript diversity at the onset of organogenesis (e8.0); the genes that comprise these changes are preferentially clustered along chromosome 7 and co...

journal_title：Developmental cell

authors： Mitiku N,Baker JC

更新日期：2007-12-01 00:00:00

abstract：:Dynamin family members are large GTPases that assemble into multimeric spirals. These spirals promote membrane fission or fusion, or they inhibit processes such as viral replication. Two new studies by Chappie et al. and Gao et al. in a recent issue of Nature identify interactions between subunits of dynamin spirals, ...

journal_title：Developmental cell

authors： van der Bliek AM,Payne GS

更新日期：2010-05-18 00:00:00

abstract：:Regulating cell proliferation and differentiation in CNS development requires both extraordinary complexity and precision. Neural progenitors receive graded overlapping signals from midline signaling centers, yet each makes a unique cell fate decision in a spatiotemporally restricted pattern. The Nde1-Lis1 complex reg...

journal_title：Developmental cell

authors： Lanctot AA,Peng CY,Pawlisz AS,Joksimovic M,Feng Y

更新日期：2013-05-13 00:00:00

abstract：:Epithelial tubes are found in many vital organs and require uniform and correct tube diameters for optimal function. Tube size depends on apical membrane growth and subapical cytoskeletal reorganization, but the cues that coordinate these events to ensure functional tube shape remain elusive. We find that epithelial t...

journal_title：Developmental cell

authors： Tonning A,Hemphälä J,Tång E,Nannmark U,Samakovlis C,Uv A

更新日期：2005-09-01 00:00:00

abstract：:Migrating fibroblasts undergo contact inhibition of locomotion (CIL), a process that was discovered five decades ago and still is not fully understood at the molecular level. We identify the Slit2-Robo4-srGAP2 signaling network as a key regulator of CIL in fibroblasts. CIL involves highly dynamic contact protrusions w...

journal_title：Developmental cell

authors： Fritz RD,Menshykau D,Martin K,Reimann A,Pontelli V,Pertz O

更新日期：2015-10-12 00:00:00

abstract：:hunchback regulates the temporal identity of neuroblasts in Drosophila. Here we show that hbl-1, the C. elegans hunchback ortholog, also controls temporal patterning. Furthermore, hbl-1 is a probable target of microRNA regulation through its 3'UTR. hbl-1 loss-of-function causes the precocious expression of adult seam ...

journal_title：Developmental cell

authors： Lin SY,Johnson SM,Abraham M,Vella MC,Pasquinelli A,Gamberi C,Gottlieb E,Slack FJ

更新日期：2003-05-01 00:00:00

abstract：:Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively stud...

journal_title：Developmental cell

authors： Curran S,Strandkvist C,Bathmann J,de Gennes M,Kabla A,Salbreux G,Baum B

更新日期：2017-11-20 00:00:00

abstract：:Reactive oxygen species (ROS), despite having damaging roles, serve as signaling molecules regulating diverse biological and physiological processes. Employing in vivo genetic studies in Drosophila, we show that besides causing G1-S arrest by activation of Dacapo, ROS can simultaneously inhibit cell growth by regulati...

journal_title：Developmental cell

authors： Toshniwal AG,Gupta S,Mandal L,Mandal S

更新日期：2019-05-06 00:00:00

abstract：:To enable stratification and barrier function, the epidermis must permit self-renewal while maintaining adhesive connections. By generating K14-GFP-actin mice to monitor actin dynamics in cultured primary keratinocytes, we uncovered a role for the actin cytoskeleton in establishing cellular organization. During epider...

journal_title：Developmental cell

authors： Vaezi A,Bauer C,Vasioukhin V,Fuchs E

更新日期：2002-09-01 00:00:00

abstract：:The protein kinase Aurora-A orchestrates key aspects of cell division, but its regulation has remained a major puzzle. That puzzle is now one step closer to being solved thanks to a recent paper by Zhao et al. appearing in the October 28(th) issue of Molecular Cell. In this work, the authors show that p21-activated ki...

journal_title：Developmental cell

authors： Cotteret S,Chernoff J

更新日期：2005-11-01 00:00:00

abstract：:Formation of the embryonic heart tube requires the medial migration and merger of bilateral precursor populations. A new study of zebrafish cardiogenesis published in this issue of Developmental Cell indicates that precursor migration involves formation of a coherent epithelium and that fibronectin plays an important ...

journal_title：Developmental cell

authors： Glickman NS,Yelon D

更新日期：2004-03-01 00:00:00

abstract：:Although many features of neurogenesis during development and in the adult are intrinsic to the neurogenic cells themselves, the role of the microenvironment is irrefutable. The neurogenic niche is a melting pot of cells and factors that influence CNS development. How do the diverse elements assemble and when? How doe...

journal_title：Developmental cell

authors： Bjornsson CS,Apostolopoulou M,Tian Y,Temple S

更新日期：2015-02-23 00:00:00

abstract：:Little is known about the mechanisms governing neonatal growth and maturation of organs. Here we demonstrate that calcineurin/Nuclear Factor of Activated T cells (Cn/NFAT) signaling regulates neonatal pancreatic development in mouse and human islets. Inactivation of calcineurin b1 (Cnb1) in mouse islets impaired dense...

journal_title：Developmental cell

authors： Goodyer WR,Gu X,Liu Y,Bottino R,Crabtree GR,Kim SK

更新日期：2012-07-17 00:00:00

abstract：:Adult neurogenic niches are present in both vertebrates and invertebrates. Where do stem cells populating these niches originate, and what are the mechanisms maintaining their self-renewal? In this issue of Developmental Cell, Benton et al. (2014) show that in crayfish, hemolymph-derived cells enter a neurogenic niche...

journal_title：Developmental cell

authors： Hartenstein V

更新日期：2014-08-11 00:00:00

abstract：:Brassinosteroids (BRs) are essential hormones for plant growth and development. BRs regulate gene expression by inducing dephosphorylation of two key transcription factors, BZR1 and BZR2/BES1, through a signal transduction pathway that involves cell-surface receptors (BRI1 and BAK1) and a GSK3 kinase (BIN2). How BR-re...

journal_title：Developmental cell

authors： Gampala SS,Kim TW,He JX,Tang W,Deng Z,Bai MY,Guan S,Lalonde S,Sun Y,Gendron JM,Chen H,Shibagaki N,Ferl RJ,Ehrhardt D,Chong K,Burlingame AL,Wang ZY

更新日期：2007-08-01 00:00:00

abstract：:Local translation allows spatial control of gene expression. Here, we performed a dual protein-mRNA localization screen, using smFISH on 523 human cell lines expressing GFP-tagged genes. 32 mRNAs displayed specific cytoplasmic localizations with local translation at unexpected locations, including cytoplasmic protrusi...

journal_title：Developmental cell

authors： Chouaib R,Safieddine A,Pichon X,Imbert A,Kwon OS,Samacoits A,Traboulsi AM,Robert MC,Tsanov N,Coleno E,Poser I,Zimmer C,Hyman A,Le Hir H,Zibara K,Peter M,Mueller F,Walter T,Bertrand E

更新日期：2020-09-28 00:00:00

abstract：:Positive autoregulation is an effective mechanism for the long-term maintenance of a transcription factor's expression. This strategy is widely deployed in cell lineages, where the autoregulatory factor controls the activity of a battery of genes that constitute the differentiation program of a postmitotic cell type. ...

journal_title：Developmental cell

authors： Liu F,Posakony JW

更新日期：2014-04-14 00:00:00

abstract：:Developmental growth requires coordination between the growth rates of individual tissues and organs. Here, we examine how Drosophila neuromuscular synapses grow to match the size of their target muscles. We show that changes in muscle growth driven by autonomous modulation of insulin receptor signaling produce corres...

journal_title：Developmental cell

authors： Ho CH,Treisman JE

更新日期：2020-07-06 00:00:00

abstract：:Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype ga...

journal_title：Developmental cell

authors： Ewen-Campen B,Mohr SE,Hu Y,Perrimon N

更新日期：2017-10-09 00:00:00