Abstract：
:While GDNF signaling through the Ret receptor is critical for kidney development, its specific role in branching morphogenesis of the epithelial ureteric bud (UB) is unclear. Ret expression defines a population of UB "tip cells" distinct from cells of the tubular "trunks," but how these cells contribute to UB growth is unknown. We have used time-lapse mosaic analysis to investigate normal cell fates within the growing UB and the developmental potential of cells lacking Ret. We found that normal tip cells are bipotential, contributing to both tips and trunks. Cells lacking Ret are specifically excluded from the tips, although they contribute to the trunks, revealing that the tips form and expand by GDNF-driven cell proliferation. Surprisingly, the mutant cells assumed an asymmetric distribution in the UB trunks, suggesting a model of branching in which the epithelium of the tip and the adjacent trunk is remodeled to form new branches.
journal_name
Dev Celljournal_title
Developmental cellauthors
Shakya R,Watanabe T,Costantini Fdoi
10.1016/j.devcel.2004.11.008keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
65-74issue
1eissn
1534-5807issn
1878-1551pii
S1534-5807(04)00406-Xjournal_volume
8pub_type
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