At the Crossroads between Cell Polarity and Adhesion in Neocortical Development.

abstract：:For 20 years, researchers have thought that circadian clocks are defined by feedback loops of transcription and translation. The rediscovery of posttranslational circadian oscillators in diverse organisms forces us to rethink this paradigm. Meanwhile, the original "basic" feedback loops of canonical circadian clocks h...

journal_title：Developmental cell

authors： Brown SA,Kowalska E,Dallmann R

更新日期：2012-03-13 00:00:00

abstract：:Presenilins are components of the gamma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch proteins. A C. elegans genetic screen revealed two genes, aph-1 and pen-2, encoding multipass transmembrane proteins, that interact strongly with sel-12/presenilin and aph-2/nicastrin. Human ap...

journal_title：Developmental cell

authors： Francis R,McGrath G,Zhang J,Ruddy DA,Sym M,Apfeld J,Nicoll M,Maxwell M,Hai B,Ellis MC,Parks AL,Xu W,Li J,Gurney M,Myers RL,Himes CS,Hiebsch R,Ruble C,Nye JS,Curtis D

更新日期：2002-07-01 00:00:00

abstract：:How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migr...

journal_title：Developmental cell

authors： Long JT,Lammerding J

更新日期：2021-01-25 00:00:00

abstract：:Neutrophils, in response to a chemoattractant gradient, undergo dynamic F-actin remodeling, a process important for their directional migration or chemotaxis. However, signaling mechanisms for chemoattractants to regulate the process are incompletely understood. Here, we characterized chemoattractant-activated signali...

journal_title：Developmental cell

authors： Tang W,Zhang Y,Xu W,Harden TK,Sondek J,Sun L,Li L,Wu D

更新日期：2011-12-13 00:00:00

abstract：:A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed commitment regulates mammalian nephrogenesis. Intersectional studies using chromatin immunoprecipitation and transcriptional profiling identified direct target genes shared by each pathway within nephron progenitors. Wnt4 and Fgf8 are e...

journal_title：Developmental cell

authors： Park JS,Ma W,O'Brien LL,Chung E,Guo JJ,Cheng JG,Valerius MT,McMahon JA,Wong WH,McMahon AP

更新日期：2012-09-11 00:00:00

abstract：:The 6th European Meiosis Workshop, sponsored by EMBO and organized by Franz Klein of the University of Vienna, met in mid-September. More than 150 participants who have not discovered anything more interesting than sex gathered in a bucolic Alpine valley near the town of Obertraun, Austria, surrounded by granite massi...

journal_title：Developmental cell

authors： Dernburg AF

更新日期：2003-11-01 00:00:00

abstract：:How kinetochores regulate microtubule dynamics to ensure proper kinetochore-microtubule interactions is unknown. Here, we studied this during early mitosis in Saccharomyces cerevisiae. When a microtubule shrinks and its plus end reaches a kinetochore bound to its lateral surface, the microtubule end attempts to tether...

journal_title：Developmental cell

authors： Gandhi SR,Gierliński M,Mino A,Tanaka K,Kitamura E,Clayton L,Tanaka TU

更新日期：2011-11-15 00:00:00

abstract：:Many promoters in eukaryotes have nucleosome-depleted regions (NDRs) containing transcription factor binding sites. However, the functional significance of NDRs is not well understood. Here, we examine NDR function in two cell cycle-regulated promoters, CLN2pr and HOpr, by varying nucleosomal coverage of the binding s...

journal_title：Developmental cell

authors： Bai L,Charvin G,Siggia ED,Cross FR

更新日期：2010-04-20 00:00:00

abstract：:Cell locomotion entails functional and structural cooperation between cell surface adhesion and the actin cytoskeleton. A new paper by DeMali et al. provides new insights into the link between actin assembly and integrin adhesion at the leading edges of migrating cells. ...

journal_title：Developmental cell

authors： Kovacs EM,Yap AS

更新日期：2002-12-01 00:00:00

abstract：:Although we know that mesenchymal progenitors give rise to nephrons in the kidney, how they balance self-renewal versus differentiation is still unclear. In this issue of Developmental Cell, Chen et al. (2015) show that nephron progenitors age, but not necessarily irreversibly: old progenitors can be "rejuvenated" by ...

journal_title：Developmental cell

authors： Little MH

更新日期：2015-10-12 00:00:00

abstract：:Septins are polymerizing GTP binding proteins required for cortical organization during cytokinesis and other cellular processes. A mammalian septin gene Sept4 is expressed mainly in postmitotic neural cells and postmeiotic male germ cells. In mouse and human spermatozoa, SEPT4 and other septins are found in the annul...

journal_title：Developmental cell

authors： Ihara M,Kinoshita A,Yamada S,Tanaka H,Tanigaki A,Kitano A,Goto M,Okubo K,Nishiyama H,Ogawa O,Takahashi C,Itohara S,Nishimune Y,Noda M,Kinoshita M

更新日期：2005-03-01 00:00:00

abstract：:Somatic muscle formation in Drosophila requires fusion of muscle founder cells with fusion-competent myoblasts. In a genetic screen for genes that control muscle development, we identified antisocial (ants), a gene that encodes an ankyrin repeat-, TPR repeat-, and RING finger-containing protein, required for myoblast ...

journal_title：Developmental cell

authors： Chen EH,Olson EN

更新日期：2001-11-01 00:00:00

abstract：:Serrate (SE) is a key component in RNA metabolism. Little is known about whether and how it can regulate epigenetic silencing. Here, we report histone methyltransferases ATXR5 and ATXR6 (ATXR5/6) as novel partners of SE. ATXR5/6 deposit histone 3 lysine 27 monomethylation (H3K27me1) to promote heterochromatin formatio...

journal_title：Developmental cell

authors： Ma Z,Castillo-González C,Wang Z,Sun D,Hu X,Shen X,Potok ME,Zhang X

更新日期：2018-06-18 00:00:00

abstract：:Differentiated cells have evolved mechanisms to adapt the functions of the late secretory pathway to the specific needs of the organism. Reporting in this issue of Developmental Cell, Polishchuk et al. (2014) demonstrate that hepatocytes utilize a unique exocytic aspect of the late endosomal/lysosomal compartment to m...

journal_title：Developmental cell

authors： Gitlin JD

更新日期：2014-06-23 00:00:00

abstract：:The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signalin...

journal_title：Developmental cell

authors： Jiang J,Hui CC

更新日期：2008-12-01 00:00:00

abstract：:In this issue of Developmental Cell, Schuster et al. (2014) describe the signals regulated by the bHLH transcription factor HEC1 during Arabidopsis stem cell maintenance. HEC1 acts antagonistically with other factors, integrating multiple cues to provide a balance between cellular differentiation and proliferation. ...

journal_title：Developmental cell

authors： Sparks EE,Benfey PN

更新日期：2014-02-24 00:00:00

abstract：:To enable stratification and barrier function, the epidermis must permit self-renewal while maintaining adhesive connections. By generating K14-GFP-actin mice to monitor actin dynamics in cultured primary keratinocytes, we uncovered a role for the actin cytoskeleton in establishing cellular organization. During epider...

journal_title：Developmental cell

authors： Vaezi A,Bauer C,Vasioukhin V,Fuchs E

更新日期：2002-09-01 00:00:00

abstract：:Many patterns of cell and tissue organization are specified during development by gradients of morphogens, substances that assign different cell fates at different concentrations. Gradients form by morphogen transport from a localized site, but whether this occurs by simple diffusion or by more elaborate mechanisms is...

journal_title：Developmental cell

authors： Lander AD,Nie Q,Wan FY

更新日期：2002-06-01 00:00:00

abstract：:During zebrafish gastrulation, mesendoderm progenitor cells differentiate to mesoderm or endoderm cells. In this issue of Developmental Cell, Barone and colleagues (2017) show that the interplay between cell-cell contact duration and morphogen signaling can control this fate segregation, providing a new framework for ...

journal_title：Developmental cell

authors： Chan CJ,Hiiragi T

更新日期：2017-10-23 00:00:00

abstract：:To ensure equal chromosome segregation during mitosis, the macromolecular kinetochore must remain attached to depolymerizing microtubules, which drive chromosome movements. How kinetochores associate with depolymerizing microtubules, which undergo dramatic structural changes forming curved protofilaments, has yet to b...

journal_title：Developmental cell

authors： Schmidt JC,Arthanari H,Boeszoermenyi A,Dashkevich NM,Wilson-Kubalek EM,Monnier N,Markus M,Oberer M,Milligan RA,Bathe M,Wagner G,Grishchuk EL,Cheeseman IM

更新日期：2012-11-13 00:00:00

abstract：:Smad4 is a central intracellular effector of TGF-beta signaling. Smad-independent TGF-beta pathways, such as those mediated by p38 MAPK, have been identified in cell culture systems, but their in vivo functional mechanisms remain unclear. In this study, we investigated the role of TGF-beta signaling in tooth and palat...

journal_title：Developmental cell

authors： Xu X,Han J,Ito Y,Bringas P Jr,Deng C,Chai Y

更新日期：2008-08-01 00:00:00

abstract：:Manipulation of cellular identity in the laboratory is generally inefficient due to stochastic events, including epigenomic alterations. Recently in Science, Zuryn et al. (2014) demonstrate that the efficiency of a naturally occurring transdifferentiation event in Caenorhabditis elegans is ensured through stepwise epi...

journal_title：Developmental cell

authors： Beyret E,Izpisua Belmonte JC

更新日期：2014-09-29 00:00:00

abstract：:Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane...

journal_title：Developmental cell

authors： Cai H,Reinisch K,Ferro-Novick S

更新日期：2007-05-01 00:00:00

abstract：:The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of these isolated neurons. Their profiles were similarly...

journal_title：Developmental cell

authors： Hattori Y,Usui T,Satoh D,Moriyama S,Shimono K,Itoh T,Shirahige K,Uemura T

更新日期：2013-12-09 00:00:00

abstract：:The Golgi apparatus undergoes a ubiquitin-dependent disassembly and reassembly process during each cycle of cell division. Here we report the identification of the Golgi t-SNARE syntaxin 5 (Syn5) as the ubiquitinated substrate. Syn5 is monoubiquitinated by the ubiquitin ligase HACE1 in early mitosis and deubiquitinate...

journal_title：Developmental cell

authors： Huang S,Tang D,Wang Y

更新日期：2016-07-11 00:00:00

abstract：:We have used Drosophila ovarian follicle stem cells (FSCs) to study how stem cells are regulated by external signals and draw three main conclusions. First, the spatial definition of supportive niche positions for FSCs depends on gradients of Hh and JAK-STAT pathway ligands, which emanate from opposite, distant sites....

journal_title：Developmental cell

authors： Vied C,Reilein A,Field NS,Kalderon D

更新日期：2012-10-16 00:00:00

abstract：:In this issue of Developmental Cell, Isabella and Horne-Badovinac (2016) show that Rab10 directs site-specific secretion of basement membrane components, which assemble into fibrils that spool out to elongate the Drosophila egg chamber. These findings establish the basement membrane's active role in tissue sculpting. ...

journal_title：Developmental cell

authors： Jayadev R,Sherwood DR

更新日期：2016-07-11 00:00:00

abstract：:The frizzled (fz) gene of Drosophila is required for planar polarity establishment in the adult cuticle, acting both cell autonomously and nonautonomously. We demonstrate that these two activities of fz in planar polarity are temporally separable in both the eye and wing. The nonautonomous function is dishevelled (dsh...

journal_title：Developmental cell

authors： Strutt H,Strutt D

更新日期：2002-12-01 00:00:00

abstract：:Polarized delivery of signaling and adhesion molecules to the leading edge is required for directional migration of cells. Here, we describe a role for the PIP(2)-synthesizing enzyme, PIPKIγi2, in regulation of exocyst complex control of cell polarity and polarized integrin trafficking during migration. Loss of PIPKIγ...

journal_title：Developmental cell

authors： Thapa N,Sun Y,Schramp M,Choi S,Ling K,Anderson RA

更新日期：2012-01-17 00:00:00

abstract：:Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of widespread expression of MAP3K4, the cellular basis of this misregulation was unclear. Here, we show that mice lacking Gadd45γ also exhibit XY gonadal sex reversal ca...

journal_title：Developmental cell

authors： Warr N,Carre GA,Siggers P,Faleato JV,Brixey R,Pope M,Bogani D,Childers M,Wells S,Scudamore CL,Tedesco M,del Barco Barrantes I,Nebreda AR,Trainor PA,Greenfield A

更新日期：2012-11-13 00:00:00