Abstract：
:Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane. However, recent findings have revealed a role for the coat in directing a vesicle to its correct intracellular destination. In this review we will discuss the literature that links coat proteins to vesicle targeting events.
journal_name
Dev Celljournal_title
Developmental cellauthors
Cai H,Reinisch K,Ferro-Novick Sdoi
10.1016/j.devcel.2007.04.005subject
Has Abstractpub_date
2007-05-01 00:00:00pages
671-82issue
5eissn
1534-5807issn
1878-1551pii
S1534-5807(07)00152-9journal_volume
12pub_type
杂志文章,评审abstract：:Oriented cell division plays a key role in controlling organogenesis. The mechanisms for regulating division orientation at the whole-organ level are only starting to become understood. By combining 3D time-lapse imaging, mouse genetics, and mathematical modeling, we find that global orientation of cell division is th...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.12.013
更新日期：2018-02-05 00:00:00
abstract：:Many different intercellular signaling pathways are known but, for most, it is unclear whether they can generate oscillating cell behaviors. Here we use time-lapse analysis of Drosophila embryogenesis to show that oenocytes delaminate from the ectoderm in discrete bursts of three. This pulsatile process has a 1 hour p...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.10.016
更新日期：2004-12-01 00:00:00
abstract：:In vertebrates, the microtubule binding protein TPX2 is required for meiotic and mitotic spindle assembly. TPX2 is also known to bind to and activate Aurora A kinase and target it to the spindle. However, the relationship between the TPX2-Aurora A interaction and the role of TPX2 in spindle assembly is unclear. Here, ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.07.002
更新日期：2005-08-01 00:00:00
abstract：:The 6th European Meiosis Workshop, sponsored by EMBO and organized by Franz Klein of the University of Vienna, met in mid-September. More than 150 participants who have not discovered anything more interesting than sex gathered in a bucolic Alpine valley near the town of Obertraun, Austria, surrounded by granite massi...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00336-8
更新日期：2003-11-01 00:00:00
abstract：:Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H₂O₂)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly w...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.12.007
更新日期：2011-02-15 00:00:00
abstract：:Unravelling the role of cytoskeleton regulators may be complicated by adaptations to experimental manipulations. In this issue of Developmental Cell, Cerikan et al. (2016) reveal how acute effects of DOCK6 RhoGEF depletion on RAC1 and CDC42 activation are reversed over time by compensatory mechanisms that re-establish...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2016.09.020
更新日期：2016-10-10 00:00:00
abstract：:Large intergenic noncoding (linc) RNAs constitute a new dimension of posttranscriptional gene regulation. In this issue of Developmental Cell, Wang et al. (2013) find that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to trap miR-145, thus regulating core pluripotency factors Oct...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2013.03.020
更新日期：2013-04-15 00:00:00
abstract：:Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki et al. (2013) suggest that the ER-...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2013.04.004
更新日期：2013-04-29 00:00:00
abstract：:Drosophila proprioceptors (chordotonal organs) are structured as a linear array of four lineage-related cells: a neuron, a glial cell, and two accessory cells, called cap and ligament, between which the neuron is stretched. To function properly as stretch receptors, chordotonal organs must be stably anchored at both e...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.07.001
更新日期：2004-08-01 00:00:00
abstract：:The Hox family transcription factors control diversified morphogenesis during development and evolution. They function in concert with Pbc cofactor proteins. Pbc proteins bind the Hox hexapeptide (HX) motif and are thereby thought to confer DNA binding specificity. Here we report that mutation of the AbdA HX motif doe...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00126-6
更新日期：2003-05-01 00:00:00
abstract：:The cytoplasm is not a homogenous solution but instead consists of large dynamic assemblies that arise from transient molecular interactions. Some of these structures have been shown to represent liquid droplets of concentrated protein and RNA. Liquid phase separation of cytoplasm may be a fundamental principle of cyt...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.06.013
更新日期：2011-07-19 00:00:00
abstract：:The large GTPase Dynamin 2 (Dyn2) is markedly upregulated in pancreatic cancer, is a potent activator of metastatic migration, and is required for Rac1-mediated formation of lamellipodia. Here we demonstrate an unexpected mechanism of Dyn2 action in these contexts via direct binding to the Rac1 guanine nucleotide exch...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.02.010
更新日期：2013-03-25 00:00:00
abstract：:SnoN regulates multiple signaling pathways, including TGF-β/Smad and p53, and displays both pro-oncogenic and anti-oncogenic activities in human cancer. We have observed previously that both its intracellular localization and expression levels are sensitive to cell density, suggesting that it may crosstalk with Hippo ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.05.002
更新日期：2016-06-06 00:00:00
abstract：:Reactive oxygen species (ROS) such as hydrogen peroxide are generated at wound sites and act as long-range signals in wound healing. The roles of other ROS in wound repair are little explored. Here, we reveal a cytoprotective role for mitochondrial ROS (mtROS) in Caenorhabditis elegans skin wound healing. We show that...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.08.002
更新日期：2014-10-13 00:00:00
abstract：:In Drosophila, commitment of a cell to a sense organ precursor (SOP) fate requires bHLH proneural transcription factor upregulation, a process that depends in most cases on the interplay of proneural gene autoregulation and inhibitory Notch signaling. A subset of SOPs are selected by a recruitment pathway involving EG...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.09.015
更新日期：2004-11-01 00:00:00
abstract：:In this issue of Developmental Cell, Tang et al. (2018) and Li et al. (2018) combine genetic manipulation, mechanical perturbation, and live imaging to show how mechanical forces and local growth factors intersect to influence epithelial behavior and cell fate specification within the developing lung. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.01.015
更新日期：2018-02-05 00:00:00
abstract：:Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the adipogenic fate of FAPs in injured and diseased muscle by restraining Hedgehog signaling. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2017.06.023
更新日期：2017-07-24 00:00:00
abstract：:Localization of the actin crosslinking protein, alpha-actinin, to the cleavage furrow has been previously reported. However, its functions during cytokinesis remain poorly understood. We have analyzed the functions of alpha-actinin during cytokinesis by a combination of molecular manipulations and imaging-based techni...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.08.003
更新日期：2007-10-01 00:00:00
abstract：:Genome condensation during mitosis presents a chromatin landscape largely inaccessible to RNA polymerase II and most transcription factors. Caravaca et al. (2013) now report in Genes and Development that the pioneer transcription factor FOXA1 is retained at mitotic chromosomes, bookmarking the genome to enable gene ex...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2013.02.005
更新日期：2013-02-25 00:00:00
abstract：:Renewing tissues have the remarkable ability to continually produce both proliferative progenitor and specialized differentiated cell types. How are complex milieus of microenvironmental signals interpreted to coordinate tissue-cell-type composition? Here, we investigate the responses of intestinal epithelium to indiv...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.12.020
更新日期：2021-01-15 00:00:00
abstract：:Regulating cell proliferation and differentiation in CNS development requires both extraordinary complexity and precision. Neural progenitors receive graded overlapping signals from midline signaling centers, yet each makes a unique cell fate decision in a spatiotemporally restricted pattern. The Nde1-Lis1 complex reg...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.04.006
更新日期：2013-05-13 00:00:00
abstract：:Mbl is a bacterial actin homolog that controls cell morphogenesis in Bacillus subtilis. A functional GFP-Mbl fusion protein was used to examine the behavior of the helical cables formed by Mbl protein in live B. subtilis cells. The cables undergo dynamic changes during cell cycle progression. They are stable but not r...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00403-3
更新日期：2003-01-01 00:00:00
abstract：:The appearance of Oskar protein occurs coincident with localization of oskar mRNA to the posterior pole of the Drosophila oocyte, and earlier accumulation of the protein is prevented by translational repression. We find that the nascent polypeptide-associated complex (NAC) is required for correct localization of oskar...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.06.009
更新日期：2004-07-01 00:00:00
abstract：:A central enigma in epigenetics is how epigenetic factors are guided to specific genomic sites for their function. Previously, we reported that a Piwi-piRNA complex associates with the piRNA-complementary site in the Drosophila genome and regulates its epigenetic state. Here, we report that Piwi-piRNA complexes bind t...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.01.023
更新日期：2013-03-11 00:00:00
abstract：:Positioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.10.009
更新日期：2016-11-07 00:00:00
abstract：:The blood brain barrier (BBB) is critical to ensure proper nervous system function and organismal health. In this issue of Developmental Cell, Babatz and colleagues explore the mechanisms of BBB maintenance and uncover a potential evolutionary link by which BBB glia construct paracellular barriers to ensure uninterrup...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.11.036
更新日期：2018-12-17 00:00:00
abstract：:Our vasculature plays diverse and critical roles in homeostasis and disease. In recent decades, the use of zebrafish has driven our understanding of vascular development into new areas, identifying new genes and mechanisms controlling vessel formation and allowing unprecedented observation of the cellular and molecula...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2017.08.015
更新日期：2017-09-25 00:00:00
abstract：:In this issue of Developmental Cell, Isabella and Horne-Badovinac (2016) show that Rab10 directs site-specific secretion of basement membrane components, which assemble into fibrils that spool out to elongate the Drosophila egg chamber. These findings establish the basement membrane's active role in tissue sculpting. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2016.06.028
更新日期：2016-07-11 00:00:00
abstract：:Several genes are known to regulate circadian rhythms in Arabidopsis, but the identity of the central oscillator has not been established. LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved. Here we demonstrate that, as shown previously for CCA1, inactivation of LHY shortens the pe...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00170-3
更新日期：2002-05-01 00:00:00
abstract：:Because mitochondria have outer and inner membranes, the fusion of two mitochondria requires the coordinated fusion of four lipid bilayers. Fusion of the outer membranes requires mitofusins. A new study published in Cell (Meeusen et al., 2006) shows that inner membrane fusion requires the dynamin-related protein Mgm1/...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.10.009
更新日期：2006-11-01 00:00:00
