Autophagosome formation: tracing the source.

abstract：:Gap junctions are present in most tissues and play essential roles in various biological processes. However, we know surprisingly little about the molecular mechanisms underlying gap junction formation. Here, we uncover the essential role of a conserved EGF- and laminin-G-domain-containing protein nlr-1/CASPR in the r...

journal_title：Developmental cell

authors： Meng L,Yan D

更新日期：2020-12-07 00:00:00

abstract：:The Ras/PI3K/extracellular signal-regulated kinases (ERK) signaling network plays fundamental roles in cell growth, survival, and migration and is frequently activated in cancer. Here, we show that the activities of the signaling network propagate as coordinated waves, biased by growth factor, which drive actin-based ...

journal_title：Developmental cell

authors： Zhan H,Bhattacharya S,Cai H,Iglesias PA,Huang CH,Devreotes PN

更新日期：2020-09-14 00:00:00

abstract：:CLIPs are microtubule plus end-associated proteins that mediate interactions required for cell polarity and cell division. Here we demonstrate that budding yeast Bik1, unlike its human ortholog CLIP-170, is targeted to the microtubule plus end by a kinesin-dependent transport mechanism. Bik1 forms a complex with the k...

journal_title：Developmental cell

authors： Carvalho P,Gupta ML Jr,Hoyt MA,Pellman D

更新日期：2004-06-01 00:00:00

abstract：:During the first five rounds of cell division in the mouse embryo, spindles assemble in the absence of centrioles. Spindle formation initiates around chromosomes, but the microtubule nucleating process remains unclear. Here we demonstrate that Plk4, a protein kinase known as a master regulator of centriole formation, ...

journal_title：Developmental cell

authors： Coelho PA,Bury L,Sharif B,Riparbelli MG,Fu J,Callaini G,Glover DM,Zernicka-Goetz M

更新日期：2013-12-09 00:00:00

abstract：:Exposure to environmental teratogenic pollutant leads to severe birth defects. However, the biological events underlying these developmental abnormalities remain undefined. Here, we report a molecular link between an environmental stress response pathway and key developmental genes during craniofacial development. Str...

journal_title：Developmental cell

authors： Zalc A,Rattenbach R,Auradé F,Cadot B,Relaix F

更新日期：2015-04-06 00:00:00

abstract：:The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of these isolated neurons. Their profiles were similarly...

journal_title：Developmental cell

authors： Hattori Y,Usui T,Satoh D,Moriyama S,Shimono K,Itoh T,Shirahige K,Uemura T

更新日期：2013-12-09 00:00:00

abstract：:Histone protein synthesis is activated as cells enter S phase to allow packaging of the newly replicated DNA into chromatin. In this issue of Developmental Cell, Takayama and coworkers elucidate a mechanism for silencing histone expression at the end of S phase in S. pombe. Failure to shut off histone expression disru...

journal_title：Developmental cell

authors： Marzluff WF

更新日期：2010-03-16 00:00:00

abstract：:Genetically identical cells in culture often exhibit significant variations, or noise, in gene expression, largely due to transcriptional bursting. Halpern et al. (2015) have developed methods to study gene bursting in tissues to find that this transcriptional bursting also occurs in the mammalian liver and may contri...

journal_title：Developmental cell

authors： Lam A,Deans TL

更新日期：2015-04-06 00:00:00

abstract：:In Drosophila, left/right (LR) asymmetry is apparent in the directional looping of the gut and male genitalia. The dextral orientation of the organs depends on the activity of a single gene, MyosinID (myoID), whose mutation leads to a fully inverted LR axis, thus revealing the activity of a recessive sinistral pathway...

journal_title：Developmental cell

authors： Coutelis JB,Géminard C,Spéder P,Suzanne M,Petzoldt AG,Noselli S

更新日期：2013-01-14 00:00:00

abstract：:One of the hardest working mitotic proteins, Polo-like kinase 1 (PLK1), functions at mitotic entry, cytokinesis, and many steps in between. In this issue, Xie et al. (2020) describe a centrosome-specific interaction between PLK1 and Retinoid X Receptor-α and they test selective inhibition of this interaction as an ant...

journal_title：Developmental cell

authors： Dos Santos A,Elowe S

更新日期：2020-12-21 00:00:00

abstract：:The eukaryotic cell cycle, driven by both transcriptional and posttranslational mechanisms, is the central molecular oscillator underlying tissue growth throughout animals. Although genome-wide studies have investigated cell-cycle-associated transcription in unicellular systems, global patterns of periodic transcripti...

journal_title：Developmental cell

authors： Liang L,Haug JS,Seidel CW,Gibson MC

更新日期：2014-04-14 00:00:00

abstract：:Despite their external bilateral symmetry, vertebrates have internal left/right (L/R) asymmetries required for optimal organ function. BMP-induced epithelial to mesenchymal transition (EMT) in the lateral plate mesoderm (LPM) triggers L/R asymmetric cell movements toward the midline, higher from the right, which are c...

journal_title：Developmental cell

authors： Rago L,Castroviejo N,Fazilaty H,Garcia-Asencio F,Ocaña OH,Galcerán J,Nieto MA

更新日期：2019-11-18 00:00:00

abstract：:Eukaryotic genomes are organized within the nucleus through interactions with inner nuclear membrane (INM) proteins. How chromatin tethering to the INM is controlled in interphase and how this process contributes to subsequent mitotic nuclear envelope (NE) remodeling remains unclear. We have probed these fundamental q...

journal_title：Developmental cell

authors： Pieper GH,Sprenger S,Teis D,Oliferenko S

更新日期：2020-04-06 00:00:00

abstract：:The cilia and cell cycles are inextricably linked. Centrioles in the basal body of cilia nucleate the ciliary axoneme and sequester pericentriolar matrix (PCM) at the centrosome to organize the mitotic spindle. Cilia themselves respond to growth signals, prompting cilia resorption and cell cycle re-entry. We describe ...

journal_title：Developmental cell

authors： Ford MJ,Yeyati PL,Mali GR,Keighren MA,Waddell SH,Mjoseng HK,Douglas AT,Hall EA,Sakaue-Sawano A,Miyawaki A,Meehan RR,Boulter L,Jackson IJ,Mill P,Mort RL

更新日期：2018-11-19 00:00:00

abstract：:Mouse anterior-posterior axis polarization is preceded by formation of the distal visceral endoderm (DVE) by unknown mechanisms. Here, we show by in vitro culturing of embryos immediately after implantation in microfabricated cavities that the external mechanical cues exerted on the embryo are crucial for DVE formatio...

journal_title：Developmental cell

authors： Hiramatsu R,Matsuoka T,Kimura-Yoshida C,Han SW,Mochida K,Adachi T,Takayama S,Matsuo I

更新日期：2013-10-28 00:00:00

abstract：:Border cells in the Drosophila ovary originate within an epithelium, detach from it, invade neighboring nurse cells, and migrate as a coherent cluster. This migration has served as a useful genetic model for understanding epithelial cell motility. The prevailing model of growth factor-mediated chemotaxis in general, a...

journal_title：Developmental cell

authors： Prasad M,Montell DJ

更新日期：2007-06-01 00:00:00

abstract：:Heparan sulfate (HS) proteoglycans modulate the activity of multiple growth factors on the cell surface and extracellular matrix. However, it remains unclear how the HS chains control the movement and reception of growth factors into targeted receiving cells during mammalian morphogenetic processes. Here, we found tha...

journal_title：Developmental cell

authors： Shimokawa K,Kimura-Yoshida C,Nagai N,Mukai K,Matsubara K,Watanabe H,Matsuda Y,Mochida K,Matsuo I

更新日期：2011-08-16 00:00:00

abstract：:In eukaryotes, small RNAs (sRNAs) have key roles in development, gene expression regulation, and genome integrity maintenance. In ciliates, such as Paramecium, sRNAs form the heart of an epigenetic system that has evolved from core eukaryotic gene silencing components to selectively target DNA for deletion. In Paramec...

journal_title：Developmental cell

authors： Sandoval PY,Swart EC,Arambasic M,Nowacki M

更新日期：2014-01-27 00:00:00

abstract：:In this issue of Developmental Cell, Chakraborty et al. report that efficient advancement through G1/S phase requires the downregulation of Nup96 levels during M phase. The authors show that oscillations in Nup96 levels plays a key role in maintaining normal cell proliferation, likely by regulating the export of speci...

journal_title：Developmental cell

authors： Wozniak RW,Goldfarb DS

更新日期：2008-11-01 00:00:00

abstract：:Mutations in Pkd1, encoding polycystin-1 (PC1), cause autosomal-dominant polycystic kidney disease (ADPKD). We show that the carboxy-terminal tail (CTT) of PC1 is released by γ-secretase-mediated cleavage and regulates the Wnt and CHOP pathways by binding the transcription factors TCF and CHOP, disrupting their intera...

journal_title：Developmental cell

authors： Merrick D,Chapin H,Baggs JE,Yu Z,Somlo S,Sun Z,Hogenesch JB,Caplan MJ

更新日期：2012-01-17 00:00:00

abstract：:In a recent issue of Nature, Bohnert and Kenyon (2017) describe a signaling pathway that prevents transgenerational inheritance of cytoplasmic protein aggregates. Fertilizing sperm trigger aggregate clearance in the ovum by a microautophagy-like effector mechanism mediated by inter-organelle communication between lyso...

journal_title：Developmental cell

authors： Patil CK,Denic V

更新日期：2018-01-08 00:00:00

abstract：:Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However, spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging. Here, we developed an optimized protocol for single-molecule transcript imaging in the intact pancreas and used it to identify a sub-po...

journal_title：Developmental cell

authors： Farack L,Golan M,Egozi A,Dezorella N,Bahar Halpern K,Ben-Moshe S,Garzilli I,Tóth B,Roitman L,Krizhanovsky V,Itzkovitz S

更新日期：2019-01-07 00:00:00

abstract：:The musculoskeletal system of vertebrates is derived from the embryonic mesoderm. Its structures are categorized as epaxial or hypaxial based on their adult position and innervation. The epaxial/hypaxial terminology is also used to describe regions of the embryonic somites based on fate mapping of somitic derivatives....

journal_title：Developmental cell

authors： Burke AC,Nowicki JL

更新日期：2003-02-01 00:00:00

abstract：:The 6th European Meiosis Workshop, sponsored by EMBO and organized by Franz Klein of the University of Vienna, met in mid-September. More than 150 participants who have not discovered anything more interesting than sex gathered in a bucolic Alpine valley near the town of Obertraun, Austria, surrounded by granite massi...

journal_title：Developmental cell

authors： Dernburg AF

更新日期：2003-11-01 00:00:00

abstract：:The Decapentaplegic and Notch signaling pathways are thought to direct regional specification in the Drosophila eye-antennal epithelium by controlling the expression of selector genes for the eye (Eyeless/Pax6, Eyes absent) and/or antenna (Distal-less). Here, we investigate the function of these signaling pathways in ...

journal_title：Developmental cell

authors： Kenyon KL,Ranade SS,Curtiss J,Mlodzik M,Pignoni F

更新日期：2003-09-01 00:00:00

abstract：:Fission yeast Pat1 kinase inhibits sexual differentiation by phosphorylating the meiotic inducer Mei2 and the transcription factor Ste11. Here, we show how Pat1 downregulates these proteins. Mei2 is degraded via a ubiquitin-proteasome pathway in a phosphorylation-dependent fashion. The E2 Ubc2 and the E3 Ubr1 are requ...

journal_title：Developmental cell

authors： Kitamura K,Katayama S,Dhut S,Sato M,Watanabe Y,Yamamoto M,Toda T

更新日期：2001-09-01 00:00:00

abstract：:Localization of the actin crosslinking protein, alpha-actinin, to the cleavage furrow has been previously reported. However, its functions during cytokinesis remain poorly understood. We have analyzed the functions of alpha-actinin during cytokinesis by a combination of molecular manipulations and imaging-based techni...

journal_title：Developmental cell

authors： Mukhina S,Wang YL,Murata-Hori M

更新日期：2007-10-01 00:00:00

abstract：:Centrosomes in mammalian cells have recently been implicated in cytokinesis; however, their role in this process is poorly defined. Here, we describe a human coiled-coil protein, Cep55 (centrosome protein 55 kDa), that localizes to the mother centriole during interphase. Despite its association with gamma-TuRC anchori...

journal_title：Developmental cell

authors： Fabbro M,Zhou BB,Takahashi M,Sarcevic B,Lal P,Graham ME,Gabrielli BG,Robinson PJ,Nigg EA,Ono Y,Khanna KK

更新日期：2005-10-01 00:00:00

abstract：:Here, we show that the liver-derived apolipoprotein M (ApoM) protects the lung and kidney from pro-fibrotic insults and that this circulating factor is attenuated in aged mice. Aged mouse hepatocytes exhibit transcriptional suppression of ApoM. This leads to reduced sphingosine-1-phosphate (S1P) signaling via the S1P ...

journal_title：Developmental cell

authors： Ding BS,Yang D,Swendeman SL,Christoffersen C,Nielsen LB,Friedman SL,Powell CA,Hla T,Cao Z

更新日期：2020-06-22 00:00:00

abstract：:The Arf tumor suppressor is a key component of the p53 tumor surveillance pathway, and its expression is activated by abnormal proliferation signals. In a recent paper, Lees and coworkers investigate the regulation of Arf expression by E2Fs and demonstrate that in normal cells E2F3 is a pivotal repressor of Arf. ...

journal_title：Developmental cell

authors： Ginsberg D

更新日期：2004-06-01 00:00:00