Abstract:
:In eukaryotes, small RNAs (sRNAs) have key roles in development, gene expression regulation, and genome integrity maintenance. In ciliates, such as Paramecium, sRNAs form the heart of an epigenetic system that has evolved from core eukaryotic gene silencing components to selectively target DNA for deletion. In Paramecium, somatic genome development from the germline genome accurately eliminates the bulk of typically gene-interrupting, noncoding DNA. We have discovered an sRNA class (internal eliminated sequence [IES] sRNAs [iesRNAs]), arising later during Paramecium development, which originates from and precisely delineates germline DNA (IESs) and complements the initial sRNAs ("scan" RNAs [scnRNAs]) in targeting DNA for elimination. We show that whole-genome duplications have facilitated successive differentiations of Paramecium Dicer-like proteins, leading to cooperation between Dcl2 and Dcl3 to produce scnRNAs and to the production of iesRNAs by Dcl5. These innovations highlight the ability of sRNA systems to acquire capabilities, including those in genome development and integrity.
journal_name
Dev Celljournal_title
Developmental cellauthors
Sandoval PY,Swart EC,Arambasic M,Nowacki Mdoi
10.1016/j.devcel.2013.12.010subject
Has Abstractpub_date
2014-01-27 00:00:00pages
174-88issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(13)00757-0journal_volume
28pub_type
杂志文章abstract::Although many features of neurogenesis during development and in the adult are intrinsic to the neurogenic cells themselves, the role of the microenvironment is irrefutable. The neurogenic niche is a melting pot of cells and factors that influence CNS development. How do the diverse elements assemble and when? How doe...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2015.01.010
更新日期:2015-02-23 00:00:00
abstract::Localization of the actin crosslinking protein, alpha-actinin, to the cleavage furrow has been previously reported. However, its functions during cytokinesis remain poorly understood. We have analyzed the functions of alpha-actinin during cytokinesis by a combination of molecular manipulations and imaging-based techni...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2007.08.003
更新日期:2007-10-01 00:00:00
abstract::Vertebrate ancestors had only cone-like photoreceptors. The duplex retina evolved in jawless vertebrates with the advent of highly photosensitive rod-like photoreceptors. Despite cones being the arbiters of high-resolution color vision, rods emerged as the dominant photoreceptor in mammals during a nocturnal phase ear...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.05.023
更新日期:2016-06-20 00:00:00
abstract::As they enter mitosis, animal cells undergo profound actin-dependent changes in shape to become round. Here we identify the Cdk1 substrate, Ect2, as a central regulator of mitotic rounding, thus uncovering a link between the cell-cycle machinery that drives mitotic entry and its accompanying actin remodeling. Ect2 is ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.06.003
更新日期:2012-08-14 00:00:00
abstract::In this issue of Developmental Cell, Ren et al. (2019) identify the embryonic origin of cardiac pacemaker cells in zebrafish and implicate Wnt5b in promoting their differentiation. Furthermore, canonical Wnt activation in human stem cell-derived cardiac progenitors produces functional pacemaker cells in vitro, advanci...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2019.09.002
更新日期:2019-09-23 00:00:00
abstract::To ensure equal chromosome segregation during mitosis, the macromolecular kinetochore must remain attached to depolymerizing microtubules, which drive chromosome movements. How kinetochores associate with depolymerizing microtubules, which undergo dramatic structural changes forming curved protofilaments, has yet to b...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.09.012
更新日期:2012-11-13 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.04.012
更新日期:2005-07-01 00:00:00
abstract::TC10, a Rho family GTPase, has been shown to play an important role in the exocytosis of GLUT4 and other proteins, primarily by tethering the vesicles at the plasma membrane. Using a newly developed probe based on fluorescence resonance energy transfer, we found that TC10 activity at tethered vesicles dropped immediat...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.07.008
更新日期:2006-09-01 00:00:00
abstract::Nakada et al. revisit the controversial question of whether membrane lipids are able to diffuse from the axon of a neuron into the soma. Using single molecule imaging of a fluorescent phospholipid, the authors show that a diffusion barrier in the axon initial segment blocks the diffusion of lipids. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/s1534-5807(03)00240-5
更新日期:2003-08-01 00:00:00
abstract::Many promoters in eukaryotes have nucleosome-depleted regions (NDRs) containing transcription factor binding sites. However, the functional significance of NDRs is not well understood. Here, we examine NDR function in two cell cycle-regulated promoters, CLN2pr and HOpr, by varying nucleosomal coverage of the binding s...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.02.007
更新日期:2010-04-20 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.03.013
更新日期:2015-05-04 00:00:00
abstract::Cells that undergo epithelial-to-mesenchymal transitions (EMTs) commonly switch from expressing E-cadherin to N-cadherin. But why this occurs is not well understood. In the current issue of Developmental Cell, Scarpa et al. (2015) identify a reason: cadherin switching controls Rac signaling to determine how cell locom...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.08.002
更新日期:2015-08-24 00:00:00
abstract::Several genes are known to regulate circadian rhythms in Arabidopsis, but the identity of the central oscillator has not been established. LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved. Here we demonstrate that, as shown previously for CCA1, inactivation of LHY shortens the pe...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00170-3
更新日期:2002-05-01 00:00:00
abstract::During early embryonic development, cells are organized as cohesive epithelial sheets that are continuously growing and remodeled without losing their integrity, giving rise to a wide array of tissue shapes. Here, using live imaging in chick embryo, we investigate how epithelial cells rearrange during gastrulation. We...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.01.007
更新日期:2016-02-08 00:00:00
abstract::Plant steroid hormones, brassinosteroids (BRs), are perceived by a cell surface receptor kinase, BRI1, but how BR binding leads to regulation of gene expression in the nucleus is unknown. Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway. A dominant mutation bzr1-...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00153-3
更新日期:2002-04-01 00:00:00
abstract::The Hippo (Hpo) signaling pathway controls tissue growth and organ size in species ranging from Drosophila to mammals and is deregulated in a wide range of human cancers. The core pathway consists of the Hpo/Warts (Wts) kinase cassette that phosphorylates and inactivates the transcriptional coactivator Yorkie (Yki). H...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.12.011
更新日期:2012-02-14 00:00:00
abstract::The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell abl...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.11.025
更新日期:2015-12-21 00:00:00
abstract::Proteins are degraded from the ER by endoplasmic reticulum-associated degradation (ERAD). In a recent issue of Molecular Cell, Fleig et al. (2012) describe a role for a ubiquitin-binding rhomboid protease, RHBDL4, in degradation of select ERAD substrates. These findings and the significance of rhomboids and other intr...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2012.08.015
更新日期:2012-09-11 00:00:00
abstract::The capacity to undergo meiosis defines vertebrate germ cells, yet mechanisms driving initiation of this specialized process are largely undefined. In this issue of Developmental Cell,Ishiguro et al. (2020) identified the transcription factor MEIOSIN as a gatekeeper of meiotic initiation in both male and female germ c...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2020.02.002
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.11.022
更新日期:2012-02-14 00:00:00
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journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2020.03.022
更新日期:2020-04-20 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.02.010
更新日期:2016-03-07 00:00:00
abstract::Reporting in Nature, Sanders et al. (2013) implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb. Actin-based filopodia transport Shh from producing cells, while filopodia of responding cells bear Cdon and Boc: coreceptors in the Shh pathway. These findings suggest a new mechanism of ligand m...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2013.05.008
更新日期:2013-05-28 00:00:00
abstract::Exponential increase of cell numbers in early embryos requires large amounts of DNA precursors (deoxyribonucleoside triphosphates (dNTPs)). Little is understood about how embryos satisfy this demand. We examined dNTP metabolism in the early Drosophila embryo, in which gastrulation is preceded by 13 sequential nuclear ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2017.06.013
更新日期:2017-08-07 00:00:00
abstract::The orientation of the mitotic spindle plays a key role in determining whether a polarized cell will divide symmetrically or asymmetrically. In most cell types, cytoplasmic dynein plays a critical role in spindle orientation. However, how dynein directs opposite spindle poles toward distinct and predetermined cell end...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.02.018
更新日期:2006-04-01 00:00:00
abstract::Hearts of mice lacking Isl1, a LIM homeodomain transcription factor, are completely missing the outflow tract, right ventricle, and much of the atria. isl1 expression and lineage tracing of isl1-expressing progenitors demonstrate that Isl1 is a marker for a distinct population of undifferentiated cardiac progenitors t...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00363-0
更新日期:2003-12-01 00:00:00
abstract::Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling functions require precise regulation of lysosomal cholesterol content. In Niemann-Pick type C (NPC), loss of the cholestero...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.11.016
更新日期:2020-12-07 00:00:00
abstract::Tissue folding is a fundamental process that shapes epithelia into complex 3D organs. The initial positioning of folds is the foundation for the emergence of correct tissue morphology. Mechanisms forming individual folds have been studied, but the precise positioning of folds in complex, multi-folded epithelia is less...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.09.009
更新日期:2019-11-04 00:00:00
abstract::The large GTPase Dynamin 2 (Dyn2) is markedly upregulated in pancreatic cancer, is a potent activator of metastatic migration, and is required for Rac1-mediated formation of lamellipodia. Here we demonstrate an unexpected mechanism of Dyn2 action in these contexts via direct binding to the Rac1 guanine nucleotide exch...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.02.010
更新日期:2013-03-25 00:00:00
abstract::Activation of Cyclin D/Cdk4 stimulates progression through the G1-S phase of the cell cycle in many organisms. In Drosophila, Cyclin D/Cdk4 also induces cell growth independently of cell cycle progression. In this issue of Developmental Cell, Frei and Edgar reveal that Cyclin D/Cdk4-stimulated growth requires Hph, a p...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/s1534-5807(04)00031-0
更新日期:2004-02-01 00:00:00