Abstract:
:During early embryonic development, cells are organized as cohesive epithelial sheets that are continuously growing and remodeled without losing their integrity, giving rise to a wide array of tissue shapes. Here, using live imaging in chick embryo, we investigate how epithelial cells rearrange during gastrulation. We find that cell division is a major rearrangement driver that powers dramatic epithelial cell intercalation events. We show that these cell division-mediated intercalations, which represent the majority of epithelial rearrangements within the early embryo, are absolutely necessary for the spatial patterning of gastrulation movements. Furthermore, we demonstrate that these intercalation events result from overall low cortical actomyosin accumulation within the epithelial cells of the embryo, which enables dividing cells to remodel junctions in their vicinity. These findings uncover a role for cell division as coordinator of epithelial growth and remodeling that might underlie various developmental, homeostatic, or pathological processes in amniotes.
journal_name
Dev Celljournal_title
Developmental cellauthors
Firmino J,Rocancourt D,Saadaoui M,Moreau C,Gros Jdoi
10.1016/j.devcel.2016.01.007subject
Has Abstractpub_date
2016-02-08 00:00:00pages
249-61issue
3eissn
1534-5807issn
1878-1551pii
S1534-5807(16)00041-1journal_volume
36pub_type
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