Regulation of plant stem cell quiescence by a brassinosteroid signaling module.

Abstract:

:The quiescent center (QC) maintains the activity of the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaining the low rate of QC cell division remain poorly understood. Here, we identified a R2R3-MYB transcription factor, BRAVO (BRASSINOSTEROIDS AT VASCULAR AND ORGANIZING CENTER), acting as a cell-specific repressor of QC divisions in the primary root of Arabidopsis. Ectopic BRAVO expression restricts overall root growth and ceases root regeneration upon damage of the stem cells, demonstrating the role of BRAVO in counteracting Brassinosteroid (BR)-mediated cell division in the QC cells. Interestingly, BR-regulated transcription factor BES1 (BRI1-EMS SUPRESSOR 1) directly represses and physically interacts with BRAVO in vivo, creating a switch that modulates QC divisions at the root stem cell niche. Together, our results define a mechanism for BR-mediated regulation of stem cell quiescence in plants.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Vilarrasa-Blasi J,González-García MP,Frigola D,Fàbregas N,Alexiou KG,López-Bigas N,Rivas S,Jauneau A,Lohmann JU,Benfey PN,Ibañes M,Caño-Delgado AI

doi

10.1016/j.devcel.2014.05.020

subject

Has Abstract

pub_date

2014-07-14 00:00:00

pages

36-47

issue

1

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(14)00340-2

journal_volume

30

pub_type

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