Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs.


:Metastasizing breast carcinoma cells have been hypothesized to mobilize tissue-invasive activity by co-opting the proteolytic systems employed by normal mammary epithelial cells undergoing branching morphogenesis. However, the critical effectors underlying morphogenesis remain unidentified, and their relationship to breast cancer invasion programs is yet to be established. Here, we identify the membrane-anchored matrix metalloproteinase, Mmp14/MT1-MMP, but not the closely related proteinase Mmp15/MT2-MMP, as the dominant proteolytic effector of both branching morphogenesis and carcinoma cell invasion in vivo. Unexpectedly, however, epithelial cell-specific targeting of Mmp14/MT1-MMP in the normal mammary gland fails to impair branching, whereas deleting the proteinase in carcinoma cells abrogates invasion, preserves matrix architecture, and completely blocks metastasis. By contrast, in the normal mammary gland, extracellular matrix remodeling and morphogenesis are ablated only when Mmp14/MT1-MMP expression is specifically deleted from the periductal stroma. Together, these findings uncover the overlapping but divergent strategies that underlie developmental versus neoplastic matrix remodeling programs.


Dev Cell


Developmental cell


Feinberg TY,Zheng H,Liu R,Wicha MS,Yu SM,Weiss SJ




Has Abstract


2018-10-22 00:00:00














  • Epigenetic Compensation Promotes Liver Regeneration.

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    journal_title:Developmental cell

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    authors: Wang S,Zhang C,Hasson D,Desai A,SenBanerjee S,Magnani E,Ukomadu C,Lujambio A,Bernstein E,Sadler KC

    更新日期:2019-07-01 00:00:00

  • Radial WNT5A-Guided Post-mitotic Filopodial Pathfinding Is Critical for Midgut Tube Elongation.

    abstract::The early midgut undergoes intensive elongation, but the underlying cellular and molecular mechanisms are unknown. The early midgut epithelium is pseudostratified, and its nuclei travel between apical and basal surfaces in concert with cell cycle. Using 3D confocal imaging and 2D live imaging, we profiled behaviors of...

    journal_title:Developmental cell

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    authors: Wang S,Cebrian C,Schnell S,Gumucio DL

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  • A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish.

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    journal_title:Developmental cell

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    authors: Birnbaum MJ

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    journal_title:Developmental cell

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    authors: Boomgarden AC,Clancy JW,D'Souza-Schorey C

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  • Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila.

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    journal_title:Developmental cell

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    authors: Rhiner C,López-Gay JM,Soldini D,Casas-Tinto S,Martín FA,Lombardía L,Moreno E

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    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Little MH

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    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Lee CH,Kiparaki M,Blanco J,Folgado V,Ji Z,Kumar A,Rimesso G,Baker NE

    更新日期:2018-08-20 00:00:00

  • Germ Cells Get by with a Little Cannibalistic Help from Their Friends.

    abstract::During development, primordial germ cells (PGCs) navigate a complex journey to generate the germline. In a recent paper in Nature Cell Biology, Nance and colleagues (Abdu et al., 2016) have discovered an unexpected step along the way: PGCs get cut in half by endodermal cells. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Krishna S,Overholtzer M

    更新日期:2016-12-19 00:00:00

  • The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

    abstract::The serine threonine kinase Akt is a core survival factor that underlies a variety of human diseases. Although regulatory phosphorylation and dephosphorylation have been well documented, the other posttranslational mechanisms that modulate Akt activity remain unclear. We show here that tetratricopeptide repeat domain ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Suizu F,Hiramuki Y,Okumura F,Matsuda M,Okumura AJ,Hirata N,Narita M,Kohno T,Yokota J,Bohgaki M,Obuse C,Hatakeyama S,Obata T,Noguchi M

    更新日期:2009-12-01 00:00:00

  • miRNA in embryonic development: the taming of Nodal signaling.

    abstract::The TGF-beta family member Nodal is one of the most potent molecules known to an embryo. Studies on Nodal regulation thus far have focused on its transcription, maturation, and interaction with antagonists. Two recent studies on the role of microRNAs (miRNAs) in Nodal signaling now reveal that something important was ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Collignon J

    更新日期:2007-10-01 00:00:00

  • The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.

    abstract::Asymmetric cell divisions generate cellular diversity. In Drosophila, embryonic neuroblasts target cell fate determinants basally, rotate their spindles by 90 degrees to align with the apical-basal axis, and divide asymmetrically in a stem cell-like fashion. In this process, apically localized Bazooka recruits Inscute...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Petritsch C,Tavosanis G,Turck CW,Jan LY,Jan YN

    更新日期:2003-02-01 00:00:00