Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs.


:Metastasizing breast carcinoma cells have been hypothesized to mobilize tissue-invasive activity by co-opting the proteolytic systems employed by normal mammary epithelial cells undergoing branching morphogenesis. However, the critical effectors underlying morphogenesis remain unidentified, and their relationship to breast cancer invasion programs is yet to be established. Here, we identify the membrane-anchored matrix metalloproteinase, Mmp14/MT1-MMP, but not the closely related proteinase Mmp15/MT2-MMP, as the dominant proteolytic effector of both branching morphogenesis and carcinoma cell invasion in vivo. Unexpectedly, however, epithelial cell-specific targeting of Mmp14/MT1-MMP in the normal mammary gland fails to impair branching, whereas deleting the proteinase in carcinoma cells abrogates invasion, preserves matrix architecture, and completely blocks metastasis. By contrast, in the normal mammary gland, extracellular matrix remodeling and morphogenesis are ablated only when Mmp14/MT1-MMP expression is specifically deleted from the periductal stroma. Together, these findings uncover the overlapping but divergent strategies that underlie developmental versus neoplastic matrix remodeling programs.


Dev Cell


Developmental cell


Feinberg TY,Zheng H,Liu R,Wicha MS,Yu SM,Weiss SJ




Has Abstract


2018-10-22 00:00:00














  • A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.

    abstract::The cilia and cell cycles are inextricably linked. Centrioles in the basal body of cilia nucleate the ciliary axoneme and sequester pericentriolar matrix (PCM) at the centrosome to organize the mitotic spindle. Cilia themselves respond to growth signals, prompting cilia resorption and cell cycle re-entry. We describe ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Ford MJ,Yeyati PL,Mali GR,Keighren MA,Waddell SH,Mjoseng HK,Douglas AT,Hall EA,Sakaue-Sawano A,Miyawaki A,Meehan RR,Boulter L,Jackson IJ,Mill P,Mort RL

    更新日期:2018-11-19 00:00:00

  • Quantitative modeling in cell biology: what is it good for?

    abstract::Recently, there has been a surge in the number of pioneering studies combining experiments with quantitative modeling to explain both relatively simple modules of molecular machinery of the cell and to achieve system-level understanding of cellular networks. Here we discuss the utility and methods of modeling and revi...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审


    authors: Mogilner A,Wollman R,Marshall WF

    更新日期:2006-09-01 00:00:00

  • Oscillation and polarity of E-cadherin asymmetries control actomyosin flow patterns during morphogenesis.

    abstract::Actomyosin flows are involved in a variety of cellular processes, including cytokinesis, cell migration, polarization, and morphogenesis. In epithelia, flow polarization orients cell deformations. It is unclear, however, how flows are polarized and how global patterns of junction remodeling emerge from flow polarizati...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Levayer R,Lecuit T

    更新日期:2013-07-29 00:00:00

  • Mitotic spindle orientation: semaphorin-plexin signaling flags the way.

    abstract::The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney deve...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Humbert PO,Gödde NJ

    更新日期:2015-05-04 00:00:00

  • Regulation of stem cells by intersecting gradients of long-range niche signals.

    abstract::We have used Drosophila ovarian follicle stem cells (FSCs) to study how stem cells are regulated by external signals and draw three main conclusions. First, the spatial definition of supportive niche positions for FSCs depends on gradients of Hh and JAK-STAT pathway ligands, which emanate from opposite, distant sites....

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Vied C,Reilein A,Field NS,Kalderon D

    更新日期:2012-10-16 00:00:00

  • Cell-cycle-dependent spatial sequestration of the DnaA replication initiator protein in Bacillus subtilis.

    abstract::Initiation of DNA replication must be restricted to occur only once per cell cycle. In most bacteria, DnaA protein binds replication origins and promotes the initiation of DNA replication. We have found that in Bacillus subtilis, DnaA only colocalizes with origin regions at early or late stages of the cell cycle, when...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Soufo CD,Soufo HJ,Noirot-Gros MF,Steindorf A,Noirot P,Graumann PL

    更新日期:2008-12-01 00:00:00

  • The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species.

    abstract::Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-dependent fission, elongate mitochondria, and mitigate brain injury. Here...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Bordt EA,Clerc P,Roelofs BA,Saladino AJ,Tretter L,Adam-Vizi V,Cherok E,Khalil A,Yadava N,Ge SX,Francis TC,Kennedy NW,Picton LK,Kumar T,Uppuluri S,Miller AM,Itoh K,Karbowski M,Sesaki H,Hill RB,Polster BM

    更新日期:2017-03-27 00:00:00

  • A Self-Organized PLT/Auxin/ARR-B Network Controls the Dynamics of Root Zonation Development in Arabidopsis thaliana.

    abstract::During organogenesis, coherent organ growth arises from spatiotemporally coordinated decisions of individual cells. In the root of Arabidopsis thaliana, this coordination results in the establishment of a division and a differentiation zone. Cells continuously move through these zones; thus, a major question is how th...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Salvi E,Rutten JP,Di Mambro R,Polverari L,Licursi V,Negri R,Dello Ioio R,Sabatini S,Ten Tusscher K

    更新日期:2020-05-18 00:00:00

  • Targeted De Novo Centromere Formation in Drosophila Reveals Plasticity and Maintenance Potential of CENP-A Chromatin.

    abstract::Centromeres are essential for accurate chromosome segregation and are marked by centromere protein A (CENP-A) nucleosomes. Mis-targeted CENP-A chromatin has been shown to seed centromeres at non-centromeric DNA. However, the requirements for such de novo centromere formation and transmission in vivo remain unknown. He...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Palladino J,Chavan A,Sposato A,Mason TD,Mellone BG

    更新日期:2020-02-10 00:00:00

  • A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

    abstract::Understanding cells as integrated systems requires that we systematically decipher how single genes affect multiple biological processes and how processes are functionally linked. Here, we used multiprocess phenotypic profiling, combining high-resolution 3D confocal microscopy and multiparametric image analysis, to si...

    journal_title:Developmental cell

    pub_type: 杂志文章


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  • Model organisms as a guide to mammalian aging.

    abstract::Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审


    authors: Tissenbaum HA,Guarente L

    更新日期:2002-01-01 00:00:00

  • Grp1 plays a key role in linking insulin signaling to glut4 recycling.

    abstract::The glucose transporter type 4 (glut4) is critical for metabolic homeostasis. Insulin regulates glut4 by modulating its expression on the cell surface. This regulation is mainly achieved by targeting the endocytic recycling of glut4. We identify general receptor for 3-phosphoinositides 1 (Grp1) as a guanine nucleotide...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Li J,Malaby AW,Famulok M,Sabe H,Lambright DG,Hsu VW

    更新日期:2012-06-12 00:00:00

  • Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouse.

    abstract::We present new approaches to cis-regulatory module (CRM) discovery in the common scenario where relevant transcription factors and/or motifs are unknown. Beginning with a small list of CRMs mediating a common gene expression pattern, we search genome-wide for CRMs with similar functionality, using new statistical scor...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Kantorovitz MR,Kazemian M,Kinston S,Miranda-Saavedra D,Zhu Q,Robinson GE,Göttgens B,Halfon MS,Sinha S

    更新日期:2009-10-01 00:00:00

  • Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair.

    abstract::Here, we show that the liver-derived apolipoprotein M (ApoM) protects the lung and kidney from pro-fibrotic insults and that this circulating factor is attenuated in aged mice. Aged mouse hepatocytes exhibit transcriptional suppression of ApoM. This leads to reduced sphingosine-1-phosphate (S1P) signaling via the S1P ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Ding BS,Yang D,Swendeman SL,Christoffersen C,Nielsen LB,Friedman SL,Powell CA,Hla T,Cao Z

    更新日期:2020-06-22 00:00:00

  • Nonautonomous planar polarity patterning in Drosophila: dishevelled-independent functions of frizzled.

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    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Strutt H,Strutt D

    更新日期:2002-12-01 00:00:00

  • Temporal coordinates: the genes that fix cell fate with birth order.

    abstract::Drosophila neuroblasts sequentially express a set of four transcription factors that specify the fates of their progeny according to the successive order of their generation. In analogy to spatial coordinate genes that specify neuroblasts by position, these sequentially expressed genes can be called "temporal coordina...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Harris WA

    更新日期:2001-09-01 00:00:00

  • CNS myelin wrapping is driven by actin disassembly.

    abstract::Myelin is essential in vertebrates for the rapid propagation of action potentials, but the molecular mechanisms driving its formation remain largely unknown. Here we show that the initial stage of process extension and axon ensheathment by oligodendrocytes requires dynamic actin filament assembly by the Arp2/3 complex...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Zuchero JB,Fu MM,Sloan SA,Ibrahim A,Olson A,Zaremba A,Dugas JC,Wienbar S,Caprariello AV,Kantor C,Leonoudakis D,Lariosa-Willingham K,Kronenberg G,Gertz K,Soderling SH,Miller RH,Barres BA

    更新日期:2015-07-27 00:00:00

  • The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage.

    abstract::The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic progenitors. Prox1 specifies lymphatic fate and labels these progenitors;...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Baek S,Oh TG,Secker G,Sutton DL,Okuda KS,Paterson S,Bower NI,Toubia J,Koltowska K,Capon SJ,Baillie GJ,Simons C,Muscat GEO,Lagendijk AK,Smith KA,Harvey NL,Hogan BM

    更新日期:2019-04-22 00:00:00

  • HEC of a job regulating stem cells.

    abstract::In this issue of Developmental Cell, Schuster et al. (2014) describe the signals regulated by the bHLH transcription factor HEC1 during Arabidopsis stem cell maintenance. HEC1 acts antagonistically with other factors, integrating multiple cues to provide a balance between cellular differentiation and proliferation. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Sparks EE,Benfey PN

    更新日期:2014-02-24 00:00:00

  • Hematopoietic lineage commitment: miRNAs add specificity to a widely expressed transcription factor.

    abstract::MicroRNAs are important regulators of normal and malignant hematopoiesis. A paper by Lu et al. in this issue of Developmental Cell demonstrates how one microRNA, miR-150, plays a critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the widely expressed transcription factor M...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: García P,Frampton J

    更新日期:2008-06-01 00:00:00

  • Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.

    abstract::How metabolism is rewired during embryonic development is still largely unknown, as it remains a major technical challenge to resolve metabolic activities or metabolite levels with spatiotemporal resolution. Here, we investigated metabolic changes during development of organogenesis-stage mouse embryos, focusing on th...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Bulusu V,Prior N,Snaebjornsson MT,Kuehne A,Sonnen KF,Kress J,Stein F,Schultz C,Sauer U,Aulehla A

    更新日期:2017-02-27 00:00:00

  • Anillin Promotes Cell Contractility by Cyclic Resetting of RhoA Residence Kinetics.

    abstract::RhoA stimulates cell contractility by recruiting downstream effectors to the cortical plasma membrane. We now show that direct binding by anillin is required for effective signaling: this antagonizes the otherwise labile membrane association of GTP-RhoA to promote effector recruitment. However, since its binding to Rh...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Budnar S,Husain KB,Gomez GA,Naghibosadat M,Varma A,Verma S,Hamilton NA,Morris RG,Yap AS

    更新日期:2019-06-17 00:00:00

  • Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle.

    abstract::Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审


    authors: Cai H,Reinisch K,Ferro-Novick S

    更新日期:2007-05-01 00:00:00

  • Membrane Mechanics in Living Cells.

    abstract::The combination of fluid and mechanical properties exhibited by cell membranes enables a wealth of physical phenomena, many of which also have biological functions. A recent study in Cell (Shi et al., 2018) now shows that membrane tension in the cell may not be as simple as it first seemed. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Groves JT

    更新日期:2019-01-07 00:00:00

  • Opposing Action of Hedgehog and Insulin Signaling Balances Proliferation and Autophagy to Determine Follicle Stem Cell Lifespan.

    abstract::Egg production declines with age in many species, a process linked with stem cell loss. Diet-dependent signaling has emerged as critical for stem cell maintenance during aging. Follicle stem cells (FSCs) in the Drosophila ovary are exquisitely responsive to diet-induced signals including Hedgehog (Hh) and insulin-IGF ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Singh T,Lee EH,Hartman TR,Ruiz-Whalen DM,O'Reilly AM

    更新日期:2018-09-24 00:00:00

  • Radial WNT5A-Guided Post-mitotic Filopodial Pathfinding Is Critical for Midgut Tube Elongation.

    abstract::The early midgut undergoes intensive elongation, but the underlying cellular and molecular mechanisms are unknown. The early midgut epithelium is pseudostratified, and its nuclei travel between apical and basal surfaces in concert with cell cycle. Using 3D confocal imaging and 2D live imaging, we profiled behaviors of...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Wang S,Cebrian C,Schnell S,Gumucio DL

    更新日期:2018-07-16 00:00:00

  • Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology.

    abstract::The generation and shedding of extracellular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of intercellular communication with important roles in several physiological processes and diseases such as cancer. These membrane-enclosed packets can transfer specific proteins, RNA...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审


    authors: Desrochers LM,Antonyak MA,Cerione RA

    更新日期:2016-05-23 00:00:00

  • Regulation of activin/nodal signaling by Rap2-directed receptor trafficking.

    abstract::We show that Rap2, a member of the Ras GTPase family, positively regulates Activin/Nodal signaling activity by controlling the trafficking of its receptors. In the absence of ligand activation, Rap2 directs internalized Activin/Nodal receptors into a recycling pathway, thereby preventing their degradation and maintain...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Choi SC,Kim GH,Lee SJ,Park E,Yeo CY,Han JK

    更新日期:2008-07-01 00:00:00

  • The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation.

    abstract::Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified cells into other cell types. This is especially critical during embryogenesis, when extensive cell proliferation, patterning, and migration events take place. Here we show that vertebrate primordial germ cells (PGCs) are pr...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Gross-Thebing T,Yigit S,Pfeiffer J,Reichman-Fried M,Bandemer J,Ruckert C,Rathmer C,Goudarzi M,Stehling M,Tarbashevich K,Seggewiss J,Raz E

    更新日期:2017-12-18 00:00:00

  • Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche.

    abstract::Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审


    authors: Gonzales KAU,Fuchs E

    更新日期:2017-11-20 00:00:00