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A flip-flop switch in polarity signaling.

Abstract：

:The Rho GTPase Cdc42 is essential for polarized growth of budding yeast. Temporal control of Cdc42 depends partly on the activity of its GTPase-activating proteins (GAPs). In this issue of Developmental Cell, Saito et al. report that Cdc42 GAP activity is regulated by the phospholipid composition of the bud-tip membrane, under control of the phospholipid flippases Lem3-Dnf1 and Lem3-Dnf2.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Menon AK

doi

10.1016/j.devcel.2007.10.008

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

607-8

issue

5

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(07)00386-3

journal_volume

13

pub_type

评论,杂志文章

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