Abstract：
:Brassinosteroids (BRs) are essential hormones for plant growth and development. BRs regulate gene expression by inducing dephosphorylation of two key transcription factors, BZR1 and BZR2/BES1, through a signal transduction pathway that involves cell-surface receptors (BRI1 and BAK1) and a GSK3 kinase (BIN2). How BR-regulated phosphorylation controls the activities of BZR1/BZR2 is not fully understood. Here, we show that BIN2-catalyzed phosphorylation of BZR1/BZR2 not only inhibits DNA binding, but also promotes binding to the 14-3-3 proteins. Mutations of a BIN2-phosphorylation site in BZR1 abolish 14-3-3 binding and lead to increased nuclear localization of BZR1 protein and enhanced BR responses in transgenic plants. Further, BR deficiency increases cytoplasmic localization, and BR treatment induces rapid nuclear localization of BZR1/BZR2. Thus, 14-3-3 binding is required for efficient inhibition of phosphorylated BR transcription factors, largely through cytoplasmic retention. This study demonstrates that multiple mechanisms are required for BR regulation of gene expression and plant growth.
journal_name
Dev Celljournal_title
Developmental cellauthors
Gampala SS,Kim TW,He JX,Tang W,Deng Z,Bai MY,Guan S,Lalonde S,Sun Y,Gendron JM,Chen H,Shibagaki N,Ferl RJ,Ehrhardt D,Chong K,Burlingame AL,Wang ZYdoi
10.1016/j.devcel.2007.06.009subject
Has Abstractpub_date
2007-08-01 00:00:00pages
177-89issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(07)00258-4journal_volume
13pub_type
杂志文章abstract：:We use the Dpp morphogen gradient in the Drosophila wing disc as a model to address the fundamental question of how a gradient of a growth factor can produce uniform growth. We first show that proper expression and subcellular localization of components in the Fat tumor-suppressor pathway, which have been argued to de...
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