SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth.

abstract：:During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in melanoblasts during embryogenesis causes defects in migration, cell-cycle progression, and cytokinesis. Rac1 null cells migrate markedly less efficiently, but s...

journal_title：Developmental cell

authors： Li A,Ma Y,Yu X,Mort RL,Lindsay CR,Stevenson D,Strathdee D,Insall RH,Chernoff J,Snapper SB,Jackson IJ,Larue L,Sansom OJ,Machesky LM

更新日期：2011-10-18 00:00:00

abstract：:The musculoskeletal system of vertebrates is derived from the embryonic mesoderm. Its structures are categorized as epaxial or hypaxial based on their adult position and innervation. The epaxial/hypaxial terminology is also used to describe regions of the embryonic somites based on fate mapping of somitic derivatives....

journal_title：Developmental cell

authors： Burke AC,Nowicki JL

更新日期：2003-02-01 00:00:00

abstract：:The eukaryotic cell cycle, driven by both transcriptional and posttranslational mechanisms, is the central molecular oscillator underlying tissue growth throughout animals. Although genome-wide studies have investigated cell-cycle-associated transcription in unicellular systems, global patterns of periodic transcripti...

journal_title：Developmental cell

authors： Liang L,Haug JS,Seidel CW,Gibson MC

更新日期：2014-04-14 00:00:00

abstract：:Vertebrate ancestors had only cone-like photoreceptors. The duplex retina evolved in jawless vertebrates with the advent of highly photosensitive rod-like photoreceptors. Despite cones being the arbiters of high-resolution color vision, rods emerged as the dominant photoreceptor in mammals during a nocturnal phase ear...

journal_title：Developmental cell

authors： Kim JW,Yang HJ,Oel AP,Brooks MJ,Jia L,Plachetzki DC,Li W,Allison WT,Swaroop A

更新日期：2016-06-20 00:00:00

abstract：:To maintain proper organ size, nature has devised trans-organ communication systems-involving both paracrine and circulating regulatory factors-to safeguard homeostasis. In this issue of Developmental Cell, Ji et al. (2019) now describe an enterohepatic feedback loop that balances tissue size and function in the mamma...

journal_title：Developmental cell

authors： Merrell AJ,Stanger BZ

更新日期：2019-02-25 00:00:00

abstract：:Several genes are known to regulate circadian rhythms in Arabidopsis, but the identity of the central oscillator has not been established. LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved. Here we demonstrate that, as shown previously for CCA1, inactivation of LHY shortens the pe...

journal_title：Developmental cell

authors： Mizoguchi T,Wheatley K,Hanzawa Y,Wright L,Mizoguchi M,Song HR,Carré IA,Coupland G

更新日期：2002-05-01 00:00:00

abstract：:Connecting phosphorylation events to kinases and phosphatases is key to understanding the molecular organization and signaling dynamics of networks. We have generated a validated set of transgenic RNA-interference reagents for knockdown and characterization of all protein kinases and phosphatases present during early ...

journal_title：Developmental cell

authors： Sopko R,Foos M,Vinayagam A,Zhai B,Binari R,Hu Y,Randklev S,Perkins LA,Gygi SP,Perrimon N

更新日期：2014-10-13 00:00:00

abstract：:Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane...

journal_title：Developmental cell

authors： Cai H,Reinisch K,Ferro-Novick S

更新日期：2007-05-01 00:00:00

abstract：:Neutrophils, in response to a chemoattractant gradient, undergo dynamic F-actin remodeling, a process important for their directional migration or chemotaxis. However, signaling mechanisms for chemoattractants to regulate the process are incompletely understood. Here, we characterized chemoattractant-activated signali...

journal_title：Developmental cell

authors： Tang W,Zhang Y,Xu W,Harden TK,Sondek J,Sun L,Li L,Wu D

更新日期：2011-12-13 00:00:00

abstract：:The gut absorbs dietary nutrients and provides a barrier to xenobiotics and microbiome metabolites. To cope with toxin exposures, the intestinal epithelium is one of the most rapidly proliferating tissues in the body. The stem cell niche supplies essential signaling factors including Wnt proteins secreted by subepithe...

journal_title：Developmental cell

authors： Chee YC,Pahnke J,Bunte R,Adsool VA,Madan B,Virshup DM

更新日期：2018-09-24 00:00:00

abstract：:Asymmetric cell divisions generate cellular diversity. In Drosophila, embryonic neuroblasts target cell fate determinants basally, rotate their spindles by 90 degrees to align with the apical-basal axis, and divide asymmetrically in a stem cell-like fashion. In this process, apically localized Bazooka recruits Inscute...

journal_title：Developmental cell

authors： Petritsch C,Tavosanis G,Turck CW,Jan LY,Jan YN

更新日期：2003-02-01 00:00:00

abstract：:The Golgi apparatus undergoes a ubiquitin-dependent disassembly and reassembly process during each cycle of cell division. Here we report the identification of the Golgi t-SNARE syntaxin 5 (Syn5) as the ubiquitinated substrate. Syn5 is monoubiquitinated by the ubiquitin ligase HACE1 in early mitosis and deubiquitinate...

journal_title：Developmental cell

authors： Huang S,Tang D,Wang Y

更新日期：2016-07-11 00:00:00

abstract：:Messenger RNAs (mRNAs) are synthesized in the cell nucleus and transported through nuclear pores to the cytoplasm for protein synthesis. Reporting in Nature Cell Biology, Mor et al. now track in living cells in real time the journey of single mRNA molecules as they transit from nucleus to cytoplasm. ...

journal_title：Developmental cell

authors： Carmo-Fonseca M

更新日期：2010-06-15 00:00:00

abstract：:Asymmetric division, a hallmark of endospore development, generates two cells, a larger mother cell and a smaller forespore. Approximately 75% of the forespore chromosome must be translocated across the division septum into the forespore by the DNA translocase SpoIIIE. Asymmetric division also triggers cell-specific t...

journal_title：Developmental cell

authors： Mohamed A,Chan H,Luhur J,Bauda E,Gallet B,Morlot C,Cole L,Awad M,Crawford S,Lyras D,Rudner DZ,Rodrigues CDA

更新日期：2021-01-11 00:00:00

abstract：:Macropinocytosis coordinates non-specific uptake of macromolecules and fluid. Cancers employ macropinocytosis to obtain nutrients to support their metabolic homeostasis. In this issue of Developmental Cell, Lee et al. (2019) report that glutamine deprivation boosts macropinocytosis via EGFR signaling induction, provid...

journal_title：Developmental cell

authors： Weerasekara VK,Patra KC,Bardeesy N

更新日期：2019-08-05 00:00:00

abstract：:Cell division axes during development are specified in different orientations to establish multicellular assemblies, but the mechanisms that generate division axis diversity remain unclear. We show here that patterns of cell contact provide cues that diversify cell division orientation by modulating cortical non-muscl...

journal_title：Developmental cell

authors： Sugioka K,Bowerman B

更新日期：2018-08-06 00:00:00

abstract：:What coordinates the internal leading and trailing edges in collectively migrating cells is largely unknown. In this issue of Developmental Cell, Barlan et al. (2017) delineate a Fat2/Lar planar signaling pathway at the basal, motile cell-cell contacts of Drosophila egg chamber follicle cells. ...

journal_title：Developmental cell

authors： Mao Q,Lavalou J,Lecuit T

更新日期：2017-03-13 00:00:00

abstract：:NAD(H)-binding proteins play important roles in cell-cycle and developmental signaling in eukaryotes. We identified a bifunctional NAD(H)-binding regulator (KidO) that integrates cell-fate signaling with cytokinesis in the bacterium Caulobacter crescentus. KidO stimulates the DivJ kinase and directly acts on the cytok...

journal_title：Developmental cell

authors： Radhakrishnan SK,Pritchard S,Viollier PH

更新日期：2010-01-19 00:00:00

abstract：:Understanding the mechanisms driving tissue and organ formation requires knowledge across scales. How do signaling pathways specify distinct tissue types? How does the patterning system control morphogenesis? How do these processes evolve? The Drosophila egg chamber, where EGF and BMP signaling intersect to specify un...

journal_title：Developmental cell

authors： Osterfield M,Berg CA,Shvartsman SY

更新日期：2017-05-22 00:00:00

abstract：:We present new approaches to cis-regulatory module (CRM) discovery in the common scenario where relevant transcription factors and/or motifs are unknown. Beginning with a small list of CRMs mediating a common gene expression pattern, we search genome-wide for CRMs with similar functionality, using new statistical scor...

journal_title：Developmental cell

authors： Kantorovitz MR,Kazemian M,Kinston S,Miranda-Saavedra D,Zhu Q,Robinson GE,Göttgens B,Halfon MS,Sinha S

更新日期：2009-10-01 00:00:00

abstract：:The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic progenitors. Prox1 specifies lymphatic fate and labels these progenitors;...

journal_title：Developmental cell

authors： Baek S,Oh TG,Secker G,Sutton DL,Okuda KS,Paterson S,Bower NI,Toubia J,Koltowska K,Capon SJ,Baillie GJ,Simons C,Muscat GEO,Lagendijk AK,Smith KA,Harvey NL,Hogan BM

更新日期：2019-04-22 00:00:00

abstract：:Drosophila neuroblasts sequentially express a set of four transcription factors that specify the fates of their progeny according to the successive order of their generation. In analogy to spatial coordinate genes that specify neuroblasts by position, these sequentially expressed genes can be called "temporal coordina...

journal_title：Developmental cell

authors： Harris WA

更新日期：2001-09-01 00:00:00

abstract：:The Hippo (Hpo) signaling pathway controls tissue growth and organ size in species ranging from Drosophila to mammals and is deregulated in a wide range of human cancers. The core pathway consists of the Hpo/Warts (Wts) kinase cassette that phosphorylates and inactivates the transcriptional coactivator Yorkie (Yki). H...

journal_title：Developmental cell

authors： Yue T,Tian A,Jiang J

更新日期：2012-02-14 00:00:00

abstract：:A century ago, Oscar Hertwig discovered that cells orient their cleavage plane orthogonal to their long axis. Reporting recently in Nature, Bosveld et al. (2016) shed light on how, showing that NuMA/Mud localization at tricellular junctions provides mitotic cells with the memory of interphase shape used to orient clea...

journal_title：Developmental cell

authors： Michel M,Dahmann C

更新日期：2016-03-21 00:00:00

abstract：:Plant steroid hormones, brassinosteroids (BRs), are perceived by a cell surface receptor kinase, BRI1, but how BR binding leads to regulation of gene expression in the nucleus is unknown. Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway. A dominant mutation bzr1-...

journal_title：Developmental cell

authors： Wang ZY,Nakano T,Gendron J,He J,Chen M,Vafeados D,Yang Y,Fujioka S,Yoshida S,Asami T,Chory J

更新日期：2002-04-01 00:00:00

abstract：:How adherens junctions (AJs) are formed upon cell division is largely unexplored. Here, we found that AJ formation is coordinated with cytokinesis and relies on an interplay between the dividing cell and its neighbors. During contraction of the cytokinetic ring, the neighboring cells locally accumulate Myosin II and p...

journal_title：Developmental cell

authors： Herszterg S,Leibfried A,Bosveld F,Martin C,Bellaiche Y

更新日期：2013-02-11 00:00:00

abstract：:In a recent issue of Molecular Cell, Cairo et al. (2013) report that the spindle checkpoint protein Mad1 shuttles between unattached kinetochores and nuclear pores. Mobile Mad1 inhibits the import receptor Kap121p, thus indirectly changing spindle dynamics. This adds nuclear transport control to the mitotic roles of M...

journal_title：Developmental cell

authors： Dasso M

更新日期：2013-01-28 00:00:00

abstract：:The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad ...

journal_title：Developmental cell

authors： Langevin J,Morgan MJ,Sibarita JB,Aresta S,Murthy M,Schwarz T,Camonis J,Bellaïche Y

更新日期：2005-09-01 00:00:00

abstract：:Intercellular communication is vital to tumor progression. In this issue of Developmental Cell, Bertolini et al. (2020) describe how small extracellular vesicles released from hypoxic mammary tumor cells facilitate intercellular communication, leading to alterations in mitochondrial dynamics and acquisition of invasiv...

journal_title：Developmental cell

authors： Boomgarden AC,Clancy JW,D'Souza-Schorey C

更新日期：2020-10-26 00:00:00

abstract：:Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling functions require precise regulation of lysosomal cholesterol content. In Niemann-Pick type C (NPC), loss of the cholestero...

journal_title：Developmental cell

authors： Davis OB,Shin HR,Lim CY,Wu EY,Kukurugya M,Maher CF,Perera RM,Ordonez MP,Zoncu R

更新日期：2020-12-07 00:00:00