Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouse.

abstract：:The Frizzled (Fz) receptor is required cell autonomously in Wnt/beta-catenin and planar cell polarity (PCP) signaling. In addition to these requirements, Fz acts nonautonomously during PCP establishment: wild-type cells surrounding fz(-) patches reorient toward the fz(-) cells. The molecular mechanism(s) of nonautonom...

journal_title：Developmental cell

authors： Wu J,Mlodzik M

更新日期：2008-09-01 00:00:00

abstract：:For 20 years, researchers have thought that circadian clocks are defined by feedback loops of transcription and translation. The rediscovery of posttranslational circadian oscillators in diverse organisms forces us to rethink this paradigm. Meanwhile, the original "basic" feedback loops of canonical circadian clocks h...

journal_title：Developmental cell

authors： Brown SA,Kowalska E,Dallmann R

更新日期：2012-03-13 00:00:00

abstract：:Unravelling the role of cytoskeleton regulators may be complicated by adaptations to experimental manipulations. In this issue of Developmental Cell, Cerikan et al. (2016) reveal how acute effects of DOCK6 RhoGEF depletion on RAC1 and CDC42 activation are reversed over time by compensatory mechanisms that re-establish...

journal_title：Developmental cell

authors： McGarry DJ,Olson MF

更新日期：2016-10-10 00:00:00

abstract：:The viral genomes of alpha- and gamma-retroviruses follow an outbound route through the cytoplasm before assembling with the budding particle at the plasma membrane. We show here that murine leukemia virus (MLV) RNAs are transported on lysosomes and transferrin-positive endosomes. Transport on transferrin-positive ves...

journal_title：Developmental cell

authors： Basyuk E,Galli T,Mougel M,Blanchard JM,Sitbon M,Bertrand E

更新日期：2003-07-01 00:00:00

abstract：:Neurite fasciculation through contact-dependent signaling is important for the wiring and function of the neuronal circuits. Here, we describe a type of axon-dendrite fasciculation in C. elegans, where proximal dendrites of the nociceptor PVD adhere to the axon of the ALA interneuron. This axon-dendrite fasciculation ...

journal_title：Developmental cell

authors： Chen CH,Hsu HW,Chang YH,Pan CL

更新日期：2019-01-28 00:00:00

abstract：:Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in various embryonic and adult tissues. Mice mutant for either Tet1 or Tet2 are viable, raising the question of whether these enzymes have overlapping roles in development. Here we have generated Tet1 and Tet2 double-knockout (DKO)...

journal_title：Developmental cell

authors： Dawlaty MM,Breiling A,Le T,Raddatz G,Barrasa MI,Cheng AW,Gao Q,Powell BE,Li Z,Xu M,Faull KF,Lyko F,Jaenisch R

更新日期：2013-02-11 00:00:00

abstract：:We use the Dpp morphogen gradient in the Drosophila wing disc as a model to address the fundamental question of how a gradient of a growth factor can produce uniform growth. We first show that proper expression and subcellular localization of components in the Fat tumor-suppressor pathway, which have been argued to de...

journal_title：Developmental cell

authors： Schwank G,Tauriello G,Yagi R,Kranz E,Koumoutsakos P,Basler K

更新日期：2011-01-18 00:00:00

abstract：:Nuclear size plays pivotal roles in gene expression, embryo development, and disease. A central hypothesis in organisms ranging from yeast to vertebrates is that nuclear size scales to cell size. This implies that nuclei may reach steady-state sizes set by limiting cytoplasmic pools of size-regulating components. By m...

journal_title：Developmental cell

authors： Mukherjee RN,Sallé J,Dmitrieff S,Nelson KM,Oakey J,Minc N,Levy DL

更新日期：2020-08-10 00:00:00

abstract：:TORC1 is arguably the best-studied regulator of cellular growth in eukaryotes. However, its activity has not been assessed in vivo in developing multicellular organisms. Two studies in this issue of Developmental Cell (Kim et al., 2017; Romero-Pozuelo et al., 2017) surprisingly reveal a patchy, cell-cycle-controlled p...

journal_title：Developmental cell

authors： Stocker H

更新日期：2017-08-21 00:00:00

abstract：:Eukaryotic genomes are organized within the nucleus through interactions with inner nuclear membrane (INM) proteins. How chromatin tethering to the INM is controlled in interphase and how this process contributes to subsequent mitotic nuclear envelope (NE) remodeling remains unclear. We have probed these fundamental q...

journal_title：Developmental cell

authors： Pieper GH,Sprenger S,Teis D,Oliferenko S

更新日期：2020-04-06 00:00:00

abstract：:Epithelial reorganization involves coordinated changes in cell shapes and movements. This restructuring occurs during formation of placodes, ectodermal thickenings that initiate the morphogenesis of epithelial organs including hair, mammary gland, and tooth. Signaling pathways in ectodermal placode formation are well ...

journal_title：Developmental cell

authors： Ahtiainen L,Lefebvre S,Lindfors PH,Renvoisé E,Shirokova V,Vartiainen MK,Thesleff I,Mikkola ML

更新日期：2014-03-10 00:00:00

abstract：:Cells entering mitosis become rounded, lose attachment to the substrate, and increase their cortical rigidity. Pivotal to these events is the dismantling of focal adhesions (FAs). How mitotic reshaping is linked to commitment to divide is unclear. Here, we show that DEPDC1B, a protein that accumulates in G2, coordinat...

journal_title：Developmental cell

authors： Marchesi S,Montani F,Deflorian G,D'Antuono R,Cuomo A,Bologna S,Mazzoccoli C,Bonaldi T,Di Fiore PP,Nicassio F

更新日期：2014-11-24 00:00:00

abstract：:Tetrapod limbs display a great variety of forms and functions. In an attempt to understand factors influencing this diversity, Cretekos and colleagues, in a recent issue of Genes & Development, provide molecular insight into the evolution of wing morphology in bats. ...

journal_title：Developmental cell

authors： Weatherbee SD

更新日期：2008-02-01 00:00:00

abstract：:The effect of intracellular vesicle trafficking on stem-cell behavior is largely unexplored. We screened the Drosophila sorting nexins (SNXs) and discovered that one, SH3PX1, profoundly affects gut homeostasis and lifespan. SH3PX1 restrains intestinal stem cell (ISC) division through an endocytosis-autophagy network t...

journal_title：Developmental cell

authors： Zhang P,Holowatyj AN,Roy T,Pronovost SM,Marchetti M,Liu H,Ulrich CM,Edgar BA

更新日期：2019-05-20 00:00:00

abstract：:Transcriptional mediators of cell stress pathways, including HIF1α, ATF4, and p53, are key to normal development and play critical roles in disease, including ischemia and cancer. Despite their importance, mechanisms by which pathways mediated by these transcription factors interact with one another are not fully unde...

journal_title：Developmental cell

authors： Guimarães-Camboa N,Stowe J,Aneas I,Sakabe N,Cattaneo P,Henderson L,Kilberg MS,Johnson RS,Chen J,McCulloch AD,Nobrega MA,Evans SM,Zambon AC

更新日期：2015-06-08 00:00:00

abstract：:RITS (RNA-induced initiation of transcriptional gene silencing complex) plays diverse roles in heterochromatin regulation: silencing transcription by recruitment of chromatin modifiers and destroying transcripts by RNAi. In a recent issue of Molecular Cell, Li et al. now show that the polymerization of Tas3, a compone...

journal_title：Developmental cell

authors： Partridge JF

更新日期：2009-05-01 00:00:00

abstract：:The conserved Hippo kinase pathway plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Whereas the function of the core kinase cascade, consisting of the serine/threonine kinases Hippo and Warts, in phosphorylating and thereby inactivating the transcri...

journal_title：Developmental cell

authors： Baumgartner R,Poernbacher I,Buser N,Hafen E,Stocker H

更新日期：2010-02-16 00:00:00

abstract：:The cytoplasm is not a homogenous solution but instead consists of large dynamic assemblies that arise from transient molecular interactions. Some of these structures have been shown to represent liquid droplets of concentrated protein and RNA. Liquid phase separation of cytoplasm may be a fundamental principle of cyt...

journal_title：Developmental cell

authors： Hyman AA,Brangwynne CP

更新日期：2011-07-19 00:00:00

abstract：:Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype ga...

journal_title：Developmental cell

authors： Ewen-Campen B,Mohr SE,Hu Y,Perrimon N

更新日期：2017-10-09 00:00:00

abstract：:Polarity is a prominent feature of both chemotaxis and cytokinesis. In chemotaxis, polarity is established by local accumulation of PI(3,4,5)P3 at the cell's leading edge, achieved through temporal and spatial regulation of PI3 kinases and the tumor suppressor, PTEN. We find that as migrating D. discoideum cells round...

journal_title：Developmental cell

authors： Janetopoulos C,Borleis J,Vazquez F,Iijima M,Devreotes P

更新日期：2005-04-01 00:00:00

abstract：:Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of widespread expression of MAP3K4, the cellular basis of this misregulation was unclear. Here, we show that mice lacking Gadd45γ also exhibit XY gonadal sex reversal ca...

journal_title：Developmental cell

authors： Warr N,Carre GA,Siggers P,Faleato JV,Brixey R,Pope M,Bogani D,Childers M,Wells S,Scudamore CL,Tedesco M,del Barco Barrantes I,Nebreda AR,Trainor PA,Greenfield A

更新日期：2012-11-13 00:00:00

abstract：:Localization of the actin crosslinking protein, alpha-actinin, to the cleavage furrow has been previously reported. However, its functions during cytokinesis remain poorly understood. We have analyzed the functions of alpha-actinin during cytokinesis by a combination of molecular manipulations and imaging-based techni...

journal_title：Developmental cell

authors： Mukhina S,Wang YL,Murata-Hori M

更新日期：2007-10-01 00:00:00

abstract：:In this issue of Developmental Cell, Chakraborty et al. report that efficient advancement through G1/S phase requires the downregulation of Nup96 levels during M phase. The authors show that oscillations in Nup96 levels plays a key role in maintaining normal cell proliferation, likely by regulating the export of speci...

journal_title：Developmental cell

authors： Wozniak RW,Goldfarb DS

更新日期：2008-11-01 00:00:00

abstract：:Centromeres are essential for accurate chromosome segregation and are marked by centromere protein A (CENP-A) nucleosomes. Mis-targeted CENP-A chromatin has been shown to seed centromeres at non-centromeric DNA. However, the requirements for such de novo centromere formation and transmission in vivo remain unknown. He...

journal_title：Developmental cell

authors： Palladino J,Chavan A,Sposato A,Mason TD,Mellone BG

更新日期：2020-02-10 00:00:00

abstract：:A century ago, Oscar Hertwig discovered that cells orient their cleavage plane orthogonal to their long axis. Reporting recently in Nature, Bosveld et al. (2016) shed light on how, showing that NuMA/Mud localization at tricellular junctions provides mitotic cells with the memory of interphase shape used to orient clea...

journal_title：Developmental cell

authors： Michel M,Dahmann C

更新日期：2016-03-21 00:00:00

abstract：:Early leaf growth is sustained by cell proliferation and subsequent cell expansion that initiates at the leaf tip and proceeds in a basipetal direction. Using detailed kinematic and gene expression studies to map these stages during early development of the third leaf of Arabidopsis thaliana, we showed that the cell-c...

journal_title：Developmental cell

authors： Andriankaja M,Dhondt S,De Bodt S,Vanhaeren H,Coppens F,De Milde L,Mühlenbock P,Skirycz A,Gonzalez N,Beemster GT,Inzé D

更新日期：2012-01-17 00:00:00

abstract：:The majority of excitatory synaptic transmission in the brain occurs at dendritic spines, which are actin-rich protrusions on the dendrites. The asymmetric nature of these structures suggests that proteins regulating cell polarity might be involved in their formation. Indeed, the polarity protein PAR-3 is required for...

journal_title：Developmental cell

authors： Zhang H,Macara IG

更新日期：2008-02-01 00:00:00

abstract：:Fission yeast Pat1 kinase inhibits sexual differentiation by phosphorylating the meiotic inducer Mei2 and the transcription factor Ste11. Here, we show how Pat1 downregulates these proteins. Mei2 is degraded via a ubiquitin-proteasome pathway in a phosphorylation-dependent fashion. The E2 Ubc2 and the E3 Ubr1 are requ...

journal_title：Developmental cell

authors： Kitamura K,Katayama S,Dhut S,Sato M,Watanabe Y,Yamamoto M,Toda T

更新日期：2001-09-01 00:00:00

abstract：:The sense organs of the vertebrate head comprise structures as varied as the eye, inner ear, and olfactory epithelium. In the early embryo, these assorted structures share a common developmental origin within the preplacodal region and acquire specific characteristics only later. Here we demonstrate a fundamental simi...

journal_title：Developmental cell

authors： Bailey AP,Bhattacharyya S,Bronner-Fraser M,Streit A

更新日期：2006-10-01 00:00:00

abstract：:Axillary meristems (AMs) give rise to lateral shoots and are critical to plant architecture. Understanding how developmental cues and environmental signals impact AM development will enable the improvement of plant architecture in agriculture. Here, we show that ARGONAUTE10 (AGO10), which sequesters miR165/166, promot...

journal_title：Developmental cell

authors： Zhang C,Fan L,Le BH,Ye P,Mo B,Chen X

更新日期：2020-12-07 00:00:00