Abstract：
:The conserved Hippo kinase pathway plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Whereas the function of the core kinase cascade, consisting of the serine/threonine kinases Hippo and Warts, in phosphorylating and thereby inactivating the transcriptional coactivator Yorkie is well established, much less is known about the upstream events that regulate Hippo signaling activity. The FERM domain proteins Expanded and Merlin appear to represent two different signaling branches that feed into the Hippo pathway. Signaling by the atypical cadherin Fat may act via Expanded, but how Merlin is regulated has remained elusive. Here, we show that the WW domain protein Kibra is a Hippo signaling component upstream of Hippo and Merlin. Kibra acts synergistically with Expanded, and it physically interacts with Merlin. Thus, Kibra predominantly acts in the Merlin branch upstream of the core kinase cascade to regulate Hippo signaling.
journal_name
Dev Celljournal_title
Developmental cellauthors
Baumgartner R,Poernbacher I,Buser N,Hafen E,Stocker Hdoi
10.1016/j.devcel.2009.12.013subject
Has Abstractpub_date
2010-02-16 00:00:00pages
309-16issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(10)00007-9journal_volume
18pub_type
杂志文章abstract：:Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the bloodstream, reach distant organs, and locally modify the microenvironment. However, visualizing these events in vivo still faces major hurdles. Here...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.01.014
更新日期：2019-02-25 00:00:00
abstract：:Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype ga...
journal_title：Developmental cell
pub_type： 杂志文章,评审
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abstract：:The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney deve...
journal_title：Developmental cell
pub_type： 评论,杂志文章
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更新日期：2015-05-04 00:00:00
abstract：:Regulating the osmotic pressure of our body fluids relies on osmosensory neurons that depolarize when their volume decreases. Recently in Neuron, Prager-Khoutorsky et al. (2014) report that this depolarization arises from direct interactions between the transient receptor potential channel TRPV1 and microtubules, whic...
journal_title：Developmental cell
pub_type： 评论,杂志文章
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abstract：:The adult, virgin mammary gland is a highly organized tree-like structure formed by ducts with hollowed lumen. Although lumen formation during pubertal development appears to involve apoptosis, the molecular mechanisms that regulate this process are not known. Here, we demonstrate that disruption of the BH3-only proap...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.12.003
更新日期：2007-02-01 00:00:00
abstract：:The ability of cells to form and release multiple classes of extracellular vesicles (EVs) is an increasingly well-recognized phenomenon. EVs are best known as mediators of intercellular communication. However, in a recent issue of Nature, Keller et al. show that they function as decoys to mitigate bacterial toxins. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2020.03.022
更新日期：2020-04-20 00:00:00
abstract：:Axillary meristems (AMs) give rise to lateral shoots and are critical to plant architecture. Understanding how developmental cues and environmental signals impact AM development will enable the improvement of plant architecture in agriculture. Here, we show that ARGONAUTE10 (AGO10), which sequesters miR165/166, promot...
journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2020-12-07 00:00:00
abstract：:TGF-beta superfamily signaling pathways emerged with the evolution of multicellular animals, suggesting that these pathways contribute to the increased diversity and complexity required for the development and homeostasis of these organisms. In this review we begin by exploring some key developmental and disease proce...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2009.02.012
更新日期：2009-03-01 00:00:00
abstract：:Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2007.04.005
更新日期：2007-05-01 00:00:00
abstract：:DNA methylation on N6-adenine (6mA) has recently been found to be a potentially epigenetic mark in several unicellular and multicellular eukaryotes. However, its distribution patterns and potential functions in land plants, which are primary producers for most ecosystems, remain largely unknown. Here we report global ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.03.012
更新日期：2018-05-07 00:00:00
abstract：:To maintain mechanical homeostasis, cells must recognize and respond to changes in cytoskeletal integrity. By imaging live cells expressing fluorescently tagged cytoskeletal proteins, we observed that actin stress fibers undergo local, acute, force-induced elongation and thinning events that compromise their stress tr...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.08.008
更新日期：2010-09-14 00:00:00
abstract：:Oxysterol binding protein-related proteins (ORPs) are conserved lipid binding polypeptides, enriched at ER contacts sites. ORPs promote non-vesicular lipid transport and work as lipid sensors in the context of many cellular tasks, but the determinants of their distinct localization and function are not understood. Her...
journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2017-12-04 00:00:00
abstract：:Myosin phosphatase-targeting subunit 1 (MYPT1) binds to the catalytic subunit of protein phosphatase 1 (PP1C). This binding is believed to target PP1C to specific substrates including myosin II, thus controlling cellular contractility. Surprisingly, we found that during mitosis, mammalian MYPT1 binds to polo-like kina...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.02.013
更新日期：2008-05-01 00:00:00
abstract：:Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified cells into other cell types. This is especially critical during embryogenesis, when extensive cell proliferation, patterning, and migration events take place. Here we show that vertebrate primordial germ cells (PGCs) are pr...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.11.019
更新日期：2017-12-18 00:00:00
abstract：:Cell division axes during development are specified in different orientations to establish multicellular assemblies, but the mechanisms that generate division axis diversity remain unclear. We show here that patterns of cell contact provide cues that diversify cell division orientation by modulating cortical non-muscl...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.06.020
更新日期：2018-08-06 00:00:00
abstract：:Developmental growth requires coordination between the growth rates of individual tissues and organs. Here, we examine how Drosophila neuromuscular synapses grow to match the size of their target muscles. We show that changes in muscle growth driven by autonomous modulation of insulin receptor signaling produce corres...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.05.015
更新日期：2020-07-06 00:00:00
abstract：:The AMP-stimulated protein kinase regulates epithelial polarity under conditions of energy depletion by phosphorylating the myosin regulatory light chain. In this issue of Developmental Cell, Mirouse et al. demonstrate that dystroglycan and perlecan, an extracellular matrix receptor and its ligand, help localize myosi...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2008.12.004
更新日期：2009-01-01 00:00:00
abstract：:The Hox family transcription factors control diversified morphogenesis during development and evolution. They function in concert with Pbc cofactor proteins. Pbc proteins bind the Hox hexapeptide (HX) motif and are thereby thought to confer DNA binding specificity. Here we report that mutation of the AbdA HX motif doe...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00126-6
更新日期：2003-05-01 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章,评审
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更新日期：2019-05-06 00:00:00
abstract：:Gene expression often requires interaction between promoters and distant enhancers, which occur within the context of highly organized topologically associating domains (TADs). Using a series of engineered chromosomal rearrangements at the Shh locus, we carried out an extensive fine-scale characterization of the facto...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.10.015
更新日期：2016-12-05 00:00:00
abstract：:Asymmetric division, a hallmark of endospore development, generates two cells, a larger mother cell and a smaller forespore. Approximately 75% of the forespore chromosome must be translocated across the division septum into the forespore by the DNA translocase SpoIIIE. Asymmetric division also triggers cell-specific t...
journal_title：Developmental cell
pub_type： 杂志文章
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journal_title：Developmental cell
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doi：10.1016/j.devcel.2011.10.030
更新日期：2012-01-17 00:00:00
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journal_title：Developmental cell
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doi：10.1016/j.devcel.2018.08.008
更新日期：2018-09-24 00:00:00
abstract：:Strigolactones secreted by plant roots are exploited by parasitic plants as germination triggers, making their synthesis and signaling important targets for crop protection. Meanwhile, genetic analyses have identified several genes required for the synthesis and signaling of an unknown shoot branching inhibitor. Two r...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.08.008
更新日期：2008-09-01 00:00:00
abstract：:Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish "winners" from "losers" during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.05.010
更新日期：2010-06-15 00:00:00
abstract：:The chemokine CXCL12 and its receptor CXCR4 have many functions during embryonic and post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling in cardiac development and found that embryonic Cxcl12-null hearts lacked intra-ventricular coronary arteries (CAs) and exhibited absent or mispl...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.03.026
更新日期：2015-05-26 00:00:00
abstract：:Since the discovery of double fertilization, it has been recognized that flowering plants produce two highly dimorphic female gametes, the egg cell and central cell. These give rise, respectively, to the embryo and the endosperm, a nourishing tissue unique to flowering plants. Here we show that in Arabidopsis, endospe...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.03.009
更新日期：2016-04-04 00:00:00
abstract：:Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling functions require precise regulation of lysosomal cholesterol content. In Niemann-Pick type C (NPC), loss of the cholestero...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.11.016
更新日期：2020-12-07 00:00:00
abstract：:Constitutive exocytosis delivers newly synthesized proteins, lipids, and other molecules from the Golgi apparatus to the cell surface. This process is mediated by vesicles, which bud off the trans-Golgi network, move along cytoskeletal filaments, and fuse with the plasma membrane. Here, we show that the small GTPase R...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.06.010
更新日期：2007-08-01 00:00:00
abstract：:CLASPs are mammalian microtubule-stabilizing proteins that can mediate the interaction between distal microtubule ends and the cell cortex. Using mass spectrometry-based assays, we have identified two CLASP partners, LL5beta and ELKS. LL5beta and ELKS form a complex that colocalizes with CLASPs at the cortex of HeLa c...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.05.012
更新日期：2006-07-01 00:00:00
