Abstract：
:Oxysterol binding protein-related proteins (ORPs) are conserved lipid binding polypeptides, enriched at ER contacts sites. ORPs promote non-vesicular lipid transport and work as lipid sensors in the context of many cellular tasks, but the determinants of their distinct localization and function are not understood. Here, we demonstrate that the yeast endocytic invaginations associate with the ER and that this association specifically requires the ORPs Osh2 and Osh3, which bridge the endocytic myosin-I Myo5 to the ER integral-membrane VAMP-associated protein (VAP) Scs2. Disruption of the ER contact with endocytic sites using ORP, VAP, myosin-I, or reticulon mutants delays and weakens actin polymerization and interferes with vesicle scission. Finally, we provide evidence suggesting that ORP-dependent sterol transfer facilitates actin polymerization at endocytic sites.
journal_name
Dev Celljournal_title
Developmental cellauthors
Encinar Del Dedo J,Idrissi FZ,Fernandez-Golbano IM,Garcia P,Rebollo E,Krzyzanowski MK,Grötsch H,Geli MIdoi
10.1016/j.devcel.2017.10.031subject
Has Abstractpub_date
2017-12-04 00:00:00pages
588-602.e6issue
5eissn
1534-5807issn
1878-1551pii
S1534-5807(17)30875-4journal_volume
43pub_type
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