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Chk1: a double agent in cell cycle checkpoints.

Abstract：

:Two cell cycle surveillance systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability. The protein kinase Chk1 is a well-established signal transducer in the DNA damage checkpoint. In this issue of Developmental Cell, Zachos et al.(2007) present evidence to indicate that Chk1 also plays a critical role in the spindle checkpoint, suggesting an interplay between the DNA damage and spindle checkpoints.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Yu H

doi

10.1016/j.devcel.2007.01.005

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

167-8

issue

2

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(07)00006-8

journal_volume

12

pub_type

评论,杂志文章

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