Abstract：
:The blood brain barrier (BBB) is critical to ensure proper nervous system function and organismal health. In this issue of Developmental Cell, Babatz and colleagues explore the mechanisms of BBB maintenance and uncover a potential evolutionary link by which BBB glia construct paracellular barriers to ensure uninterrupted protection throughout development.
journal_name
Dev Celljournal_title
Developmental cellauthors
Coutinho-Budd Jdoi
10.1016/j.devcel.2018.11.036subject
Has Abstractpub_date
2018-12-17 00:00:00pages
688-689issue
6eissn
1534-5807issn
1878-1551pii
S1534-5807(18)31019-0journal_volume
47pub_type
评论,杂志文章abstract：:Airway smooth muscle is best known for its role as an airway constrictor in diseases such as asthma. However, its function in lung development is debated. A prevalent model, supported by in vitro data, posits that airway smooth muscle promotes lung branching through peristalsis and pushing intraluminal fluid to branch...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.02.001
更新日期：2020-04-06 00:00:00
abstract：:Reactive oxygen species (ROS), despite having damaging roles, serve as signaling molecules regulating diverse biological and physiological processes. Employing in vivo genetic studies in Drosophila, we show that besides causing G1-S arrest by activation of Dacapo, ROS can simultaneously inhibit cell growth by regulati...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.04.008
更新日期：2019-05-06 00:00:00
abstract：:Many human genes generate mRNAs with alternative 3' untranslated regions (3' UTRs), which can modulate protein function. In a recent Cell paper, Ma and Mayr (2018) unveil a major membraneless organelle, termed the TIS granule-endoplasmic reticulum (TIGER), which enables specific 3' UTRs to encipher protein localizatio...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.11.022
更新日期：2018-12-03 00:00:00
abstract：:In this issue of Developmental Cell, Tang et al. (2018) and Li et al. (2018) combine genetic manipulation, mechanical perturbation, and live imaging to show how mechanical forces and local growth factors intersect to influence epithelial behavior and cell fate specification within the developing lung. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.01.015
更新日期：2018-02-05 00:00:00
abstract：:The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell abl...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.11.025
更新日期：2015-12-21 00:00:00
abstract：:How adherens junctions (AJs) are formed upon cell division is largely unexplored. Here, we found that AJ formation is coordinated with cytokinesis and relies on an interplay between the dividing cell and its neighbors. During contraction of the cytokinetic ring, the neighboring cells locally accumulate Myosin II and p...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.11.019
更新日期：2013-02-11 00:00:00
abstract：:The Rho GTPase Cdc42 is essential for polarized growth of budding yeast. Temporal control of Cdc42 depends partly on the activity of its GTPase-activating proteins (GAPs). In this issue of Developmental Cell, Saito et al. report that Cdc42 GAP activity is regulated by the phospholipid composition of the bud-tip membra...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2007.10.008
更新日期：2007-11-01 00:00:00
abstract：:The extensive subcellular network of membrane contact sites plays central roles in organelle biogenesis and communication, yet the precise contributions of the involved machineries remain largely enigmatic. The yeast vacuole forms a membrane contact site with mitochondria, called vacuolar and mitochondrial patch (vCLA...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.05.011
更新日期：2018-06-04 00:00:00
abstract：:How kinetochores regulate microtubule dynamics to ensure proper kinetochore-microtubule interactions is unknown. Here, we studied this during early mitosis in Saccharomyces cerevisiae. When a microtubule shrinks and its plus end reaches a kinetochore bound to its lateral surface, the microtubule end attempts to tether...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.09.006
更新日期：2011-11-15 00:00:00
abstract：:In this issue of Developmental Cell, Gibson and colleagues (Ramanathan et al., 2019) investigate the relationship between size and shape in epithelial cells. They find that cell size impacts cell shape, with unexpected consequences for epithelial growth and morphogenesis, particularly the clonal dynamics of epithelial...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2019.09.015
更新日期：2019-10-07 00:00:00
abstract：:During early embryonic development, cells are organized as cohesive epithelial sheets that are continuously growing and remodeled without losing their integrity, giving rise to a wide array of tissue shapes. Here, using live imaging in chick embryo, we investigate how epithelial cells rearrange during gastrulation. We...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.01.007
更新日期：2016-02-08 00:00:00
abstract：:Bazooka/Par-3 (Baz) is a key regulator of cell polarity in epithelial cells and neuroblasts (NBs). Phosphorylation of Baz by PAR-1 and aPKC is required for its function in epithelia, but little is known about the dephosphorylation mechanisms that antagonize the activities of these kinases or about the relevance of Baz...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.04.011
更新日期：2009-06-01 00:00:00
abstract：:In Drosophila, commitment of a cell to a sense organ precursor (SOP) fate requires bHLH proneural transcription factor upregulation, a process that depends in most cases on the interplay of proneural gene autoregulation and inhibitory Notch signaling. A subset of SOPs are selected by a recruitment pathway involving EG...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.09.015
更新日期：2004-11-01 00:00:00
abstract：:DNA methylation on N6-adenine (6mA) has recently been found to be a potentially epigenetic mark in several unicellular and multicellular eukaryotes. However, its distribution patterns and potential functions in land plants, which are primary producers for most ecosystems, remain largely unknown. Here we report global ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.03.012
更新日期：2018-05-07 00:00:00
abstract：:The epidermis of aerial plant organs is thought to be limiting for growth, because it acts as a continuous load-bearing layer, resisting tension. Leaf epidermis contains jigsaw puzzle piece-shaped pavement cells whose shape has been proposed to be a result of subcellular variations in expansion rate that induce local ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.10.017
更新日期：2017-11-06 00:00:00
abstract：:22q11 deletion (del22q11) syndrome is characterized genetically by heterozygous deletions within chromosome 22q11 and clinically by a constellation of congenital malformations of the aortic arch, heart, thymus, and parathyroid glands described as DiGeorge syndrome (DGS). Here, we report that compound heterozygosity of...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.12.002
更新日期：2006-01-01 00:00:00
abstract：:The connection between cell fate transitions and metabolic shifts is gaining momentum in the study of cell differentiation in embryonic development, adult stem cells, and cancer pathogenesis. Here, we explore how metabolic transitions influence post-translational modifications (PTMs), which play central roles in the a...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2020.06.035
更新日期：2020-07-20 00:00:00
abstract：:Our vasculature plays diverse and critical roles in homeostasis and disease. In recent decades, the use of zebrafish has driven our understanding of vascular development into new areas, identifying new genes and mechanisms controlling vessel formation and allowing unprecedented observation of the cellular and molecula...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2017.08.015
更新日期：2017-09-25 00:00:00
abstract：:Tight junctions contribute to epithelial barrier function by selectively regulating the quantity and type of molecules that cross the paracellular barrier. Experimental approaches to evaluate the effectiveness of tight junctions are typically global, tissue-scale measures. Here, we introduce Zinc-based Ultrasensitive ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.01.016
更新日期：2019-02-25 00:00:00
abstract：:Zebrafish heart regeneration occurs through the activation of cardiomyocyte proliferation in areas of trauma. Here, we show that within 3 hr of ventricular injury, the entire endocardium undergoes morphological changes and induces expression of the retinoic acid (RA)-synthesizing enzyme raldh2. By one day posttrauma, ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.01.010
更新日期：2011-03-15 00:00:00
abstract：:Strigolactones secreted by plant roots are exploited by parasitic plants as germination triggers, making their synthesis and signaling important targets for crop protection. Meanwhile, genetic analyses have identified several genes required for the synthesis and signaling of an unknown shoot branching inhibitor. Two r...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.08.008
更新日期：2008-09-01 00:00:00
abstract：:The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds. ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.07.011
更新日期：2012-08-14 00:00:00
abstract：:Several genes are known to regulate circadian rhythms in Arabidopsis, but the identity of the central oscillator has not been established. LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved. Here we demonstrate that, as shown previously for CCA1, inactivation of LHY shortens the pe...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00170-3
更新日期：2002-05-01 00:00:00
abstract：:The Drosophila compound eye consists of approximately 750 independently functioning ommatidia, each containing two photoreceptor subpopulations. The outer photoreceptors participate in motion detection, while the inner photoreceptors contribute to color vision. Although the inner photoreceptors, R7 and R8, terminally ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00156-4
更新日期：2003-06-01 00:00:00
abstract：:The early midgut undergoes intensive elongation, but the underlying cellular and molecular mechanisms are unknown. The early midgut epithelium is pseudostratified, and its nuclei travel between apical and basal surfaces in concert with cell cycle. Using 3D confocal imaging and 2D live imaging, we profiled behaviors of...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.06.011
更新日期：2018-07-16 00:00:00
abstract：:Septins are polymerizing GTP binding proteins required for cortical organization during cytokinesis and other cellular processes. A mammalian septin gene Sept4 is expressed mainly in postmitotic neural cells and postmeiotic male germ cells. In mouse and human spermatozoa, SEPT4 and other septins are found in the annul...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.12.005
更新日期：2005-03-01 00:00:00
abstract：:Mammalian lungs are comprised of conducting airways and alveoli. How the distinct epithelial linings of these two zones are differentially specified and maintained is not fully understood. In this issue of Developmental Cell, two groups find critical roles for the Hippo pathway in regulation of lung progenitor cell di...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2014.07.002
更新日期：2014-07-28 00:00:00
abstract：:For many years, biologists have focused on the role of Pitx2, expressed on the left side of developing embryos, in governing organ laterality. Here, we identify a different pathway during left-right asymmetry initiated by the right side of the embryo. Surprisingly, this conserved mechanism is orchestrated by the extra...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.08.002
更新日期：2018-09-10 00:00:00
abstract：:Lysosomes degrade macromolecular cargos, recycle catabolites, and serve as signaling platforms to maintain cell homeostasis, but their role at the tissue level is unclear. Here, we investigate lysosome regulation and function during C. elegans molting, a specialized extracellular matrix (ECM) remodeling process essent...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.10.020
更新日期：2020-01-06 00:00:00
abstract：:DSL ligands promote proteolysis of the Notch receptor, to release active Notch intracellular domain (N(ICD)). Conversely, the E3 ubiquitin ligase Deltex can activate ligand-independent Notch proteolysis and signaling. Here we show that Deltex effects require endocytic trafficking by HOPS and AP-3 complexes. Our data s...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.09.002
更新日期：2008-11-01 00:00:00
