Abstract：
:The Drosophila compound eye consists of approximately 750 independently functioning ommatidia, each containing two photoreceptor subpopulations. The outer photoreceptors participate in motion detection, while the inner photoreceptors contribute to color vision. Although the inner photoreceptors, R7 and R8, terminally differentiate into functionally related cells, they differ in their molecular and morphological makeup. Our data indicates that several aspects of R7 versus R8 cell fate determination are regulated by the transcription factor Prospero (Pros). pros is specifically expressed in R7 cells, and R7 cells mutant for pros derepress R8 rhodopsins, lose R7 rhodopsins and acquire an R8-like morphology. This suggests that R7 inner photoreceptor cell fate is acquired from a default R8-like fate that is regulated, in part, via the direct transcriptional repression of R8 rhodopsins in R7 cells. Furthermore, this study provides transcriptional targets for pros that may lend insight into its role in regulating neuronal development in flies and vertebrates.
journal_name
Dev Celljournal_title
Developmental cellauthors
Cook T,Pichaud F,Sonneville R,Papatsenko D,Desplan Cdoi
10.1016/s1534-5807(03)00156-4keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
853-64issue
6eissn
1534-5807issn
1878-1551pii
S1534-5807(03)00156-4journal_volume
4pub_type
杂志文章abstract：:In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes an...
journal_title：Developmental cell
pub_type： 杂志文章,评审
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journal_title：Developmental cell
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