Membrane targeting of endocytic adaptors: cargo and lipid do it together.

abstract：:Exposure to environmental teratogenic pollutant leads to severe birth defects. However, the biological events underlying these developmental abnormalities remain undefined. Here, we report a molecular link between an environmental stress response pathway and key developmental genes during craniofacial development. Str...

journal_title：Developmental cell

authors： Zalc A,Rattenbach R,Auradé F,Cadot B,Relaix F

更新日期：2015-04-06 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes. Here, we show that the transmembrane protein, Nogo-A, inhibits neurite outgrowth and cell spreading in neurons and Nogo-A-responsive cell lines via HSPGs. The extracellular, active 180 amino acid Nogo-A regio...

journal_title：Developmental cell

authors： Kempf A,Boda E,Kwok JCF,Fritz R,Grande V,Kaelin AM,Ristic Z,Schmandke A,Schmandke A,Tews B,Fawcett JW,Pertz O,Buffo A,Schwab ME

更新日期：2017-10-09 00:00:00

abstract：:Stem cell differentiation involves a delicate balance of gene expression and transposon repression. In this issue of Developmental Cell, Shibata et al. (2016) show that a PIWI protein expressed in planarian stem cells is inherited by their differentiating descendants to ensure regenerative capacity of the flatworm via...

journal_title：Developmental cell

authors： Tharp ME,Bortvin A

更新日期：2016-05-09 00:00:00

abstract：:The Ras/PI3K/extracellular signal-regulated kinases (ERK) signaling network plays fundamental roles in cell growth, survival, and migration and is frequently activated in cancer. Here, we show that the activities of the signaling network propagate as coordinated waves, biased by growth factor, which drive actin-based ...

journal_title：Developmental cell

authors： Zhan H,Bhattacharya S,Cai H,Iglesias PA,Huang CH,Devreotes PN

更新日期：2020-09-14 00:00:00

abstract：:Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation by regulating entry and progression of cells through the DNA synthesis phase. Cyclin E expression is normally restricted to proliferating cells. However, high levels of cyclin E are expressed in the adult brain. The function of ...

journal_title：Developmental cell

authors： Odajima J,Wills ZP,Ndassa YM,Terunuma M,Kretschmannova K,Deeb TZ,Geng Y,Gawrzak S,Quadros IM,Newman J,Das M,Jecrois ME,Yu Q,Li N,Bienvenu F,Moss SJ,Greenberg ME,Marto JA,Sicinski P

更新日期：2011-10-18 00:00:00

abstract：:Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional ...

journal_title：Developmental cell

authors： Langer EM,Feng Y,Zhaoyuan H,Rauscher FJ 3rd,Kroll KL,Longmore GD

更新日期：2008-03-01 00:00:00

abstract：:The quiescent center (QC) maintains the activity of the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaining the low rate of QC cell division remain poorly understood. Here, we identified a R2R3-MYB transcription factor, BRAVO (BRASSINOSTEROIDS AT VASCULAR AND ORGANIZING CE...

journal_title：Developmental cell

authors： Vilarrasa-Blasi J,González-García MP,Frigola D,Fàbregas N,Alexiou KG,López-Bigas N,Rivas S,Jauneau A,Lohmann JU,Benfey PN,Ibañes M,Caño-Delgado AI

更新日期：2014-07-14 00:00:00

abstract：:To maintain proper organ size, nature has devised trans-organ communication systems-involving both paracrine and circulating regulatory factors-to safeguard homeostasis. In this issue of Developmental Cell, Ji et al. (2019) now describe an enterohepatic feedback loop that balances tissue size and function in the mamma...

journal_title：Developmental cell

authors： Merrell AJ,Stanger BZ

更新日期：2019-02-25 00:00:00

abstract：:The identities of the ubiquitin-ligases active during myogenesis are largely unknown. Here we describe a RING-type E3 ligase complex specified by the adaptor protein, Ozz, a novel SOCS protein that is developmentally regulated and expressed exclusively in striated muscle. In mice, the absence of Ozz results in overt m...

journal_title：Developmental cell

authors： Nastasi T,Bongiovanni A,Campos Y,Mann L,Toy JN,Bostrom J,Rottier R,Hahn C,Conaway JW,Harris AJ,D'Azzo A

更新日期：2004-02-01 00:00:00

abstract：:RNA-binding Fox (Rbfox) proteins have well-established roles in regulating alternative splicing, but specific Rbfox isoforms lack nuclear localization signals and accumulate in the cytoplasm. The potential splicing-independent functions of these proteins remain unknown. Here we demonstrate that cytoplasmic Drosophila ...

journal_title：Developmental cell

authors： Carreira-Rosario A,Bhargava V,Hillebrand J,Kollipara RK,Ramaswami M,Buszczak M

更新日期：2016-03-07 00:00:00

abstract：:Early leaf growth is sustained by cell proliferation and subsequent cell expansion that initiates at the leaf tip and proceeds in a basipetal direction. Using detailed kinematic and gene expression studies to map these stages during early development of the third leaf of Arabidopsis thaliana, we showed that the cell-c...

journal_title：Developmental cell

authors： Andriankaja M,Dhondt S,De Bodt S,Vanhaeren H,Coppens F,De Milde L,Mühlenbock P,Skirycz A,Gonzalez N,Beemster GT,Inzé D

更新日期：2012-01-17 00:00:00

abstract：:Phase separation represents an important form of subcellular compartmentalization. However, relatively little is known about how the formation or disassembly of such compartments is regulated. In zebrafish, the Balbiani body (Bb) and the germ plasm (Gp) are intimately linked phase-separated structures essential for ge...

journal_title：Developmental cell

authors： Roovers EF,Kaaij LJT,Redl S,Bronkhorst AW,Wiebrands K,de Jesus Domingues AM,Huang HY,Han CT,Riemer S,Dosch R,Salvenmoser W,Grün D,Butter F,van Oudenaarden A,Ketting RF

更新日期：2018-08-06 00:00:00

abstract：:Mammalian neurulation is completed when the dorsolateral neural folds bend inwards, their tips make adhesive contacts across the midline, and the epithelia remodel to create a closed neural tube. Two recent papers (one by Camerer et al. in this issue of Developmental Cell) demonstrate a vital role for protease-activat...

journal_title：Developmental cell

authors： Copp AJ,Greene ND

更新日期：2010-01-19 00:00:00

abstract：:Regulated turnover of integrin receptors is essential for cell adhesion and migration. Pathways selectively regulating β1-integrin recycling are implicated in cancer invasion and metastasis, yet proteins required for the internalization of this pro-invasive integrin remain to be identified. Here, we uncover formin-lik...

journal_title：Developmental cell

authors： Wang Y,Arjonen A,Pouwels J,Ta H,Pausch P,Bange G,Engel U,Pan X,Fackler OT,Ivaska J,Grosse R

更新日期：2015-08-24 00:00:00

abstract：:The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds. ...

journal_title：Developmental cell

authors： Bazan JF,Janda CY,Garcia KC

更新日期：2012-08-14 00:00:00

abstract：:Recently reporting in Molecular Cell, Hussey et al. (2011) find that hnRNP E1 inhibits the translation of several genes essential for the epithelial-to-mesenchymal transition (EMT) by blocking eEF1A1 release during translation elongation. Phosphorylation of hnRNP E1 in response to TGF-β signaling disrupts the hnRNP E1...

journal_title：Developmental cell

authors： Zhang YE

更新日期：2011-03-15 00:00:00

abstract：:The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the renal collecting system. Although development of a normal kidney depends on proper ureteric bud morphogenesis, the cellular events underlying this process remain obscure. Here, we used time-lapse microscopy together with several ...

journal_title：Developmental cell

authors： Packard A,Georgas K,Michos O,Riccio P,Cebrian C,Combes AN,Ju A,Ferrer-Vaquer A,Hadjantonakis AK,Zong H,Little MH,Costantini F

更新日期：2013-11-11 00:00:00

abstract：:The faithful alignment of homologous chromosomes during meiotic prophase requires the coordination of DNA double-strand break (DSB) repair with large-scale chromosome reorganization. Here we identify the phosphatase PP4 (Pph3/Psy2) as a mediator of this process in Saccharomyces cerevisiae. In pp4 mutants, early stages...

journal_title：Developmental cell

authors： Falk JE,Chan AC,Hoffmann E,Hochwagen A

更新日期：2010-10-19 00:00:00

abstract：:Here, we show that the liver-derived apolipoprotein M (ApoM) protects the lung and kidney from pro-fibrotic insults and that this circulating factor is attenuated in aged mice. Aged mouse hepatocytes exhibit transcriptional suppression of ApoM. This leads to reduced sphingosine-1-phosphate (S1P) signaling via the S1P ...

journal_title：Developmental cell

authors： Ding BS,Yang D,Swendeman SL,Christoffersen C,Nielsen LB,Friedman SL,Powell CA,Hla T,Cao Z

更新日期：2020-06-22 00:00:00

abstract：:Lipid droplets are fat storage organelles in cells that physically resemble stable oil-water emulsion droplets. In this issue of Developmental Cell, Ben M'barek et al. (2017) show that the resemblance is more than superficial: physical principles governing emulsion stability also control lipid droplet nucleation and g...

journal_title：Developmental cell

authors： Roux A,Loewith R

更新日期：2017-06-19 00:00:00

abstract：:Growth and development are coordinated by an array of intercellular communications. Known plant signaling molecules include phytohormones and hormone peptides. Although both classes can be implicated in the same developmental processes, little is known about the interplay between phytohormone action and peptide signal...

journal_title：Developmental cell

authors： Whitford R,Fernandez A,Tejos R,Pérez AC,Kleine-Vehn J,Vanneste S,Drozdzecki A,Leitner J,Abas L,Aerts M,Hoogewijs K,Baster P,De Groodt R,Lin YC,Storme V,Van de Peer Y,Beeckman T,Madder A,Devreese B,Luschnig C,Friml

更新日期：2012-03-13 00:00:00

abstract：:Alzheimer's disease remains a formidable challenge for therapeutic management. In a recent report in Nature Structural and Molecular Biology, Cohen et al. (2015) present intriguing results showing that "designer" molecular chaperones may hold the key to an evolutionarily conserved program for management of toxic oligo...

journal_title：Developmental cell

authors： Singh JK,Balch WE

更新日期：2015-03-23 00:00:00

abstract：:Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However, spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging. Here, we developed an optimized protocol for single-molecule transcript imaging in the intact pancreas and used it to identify a sub-po...

journal_title：Developmental cell

authors： Farack L,Golan M,Egozi A,Dezorella N,Bahar Halpern K,Ben-Moshe S,Garzilli I,Tóth B,Roitman L,Krizhanovsky V,Itzkovitz S

更新日期：2019-01-07 00:00:00

abstract：:RITS (RNA-induced initiation of transcriptional gene silencing complex) plays diverse roles in heterochromatin regulation: silencing transcription by recruitment of chromatin modifiers and destroying transcripts by RNAi. In a recent issue of Molecular Cell, Li et al. now show that the polymerization of Tas3, a compone...

journal_title：Developmental cell

authors： Partridge JF

更新日期：2009-05-01 00:00:00

abstract：:Activation of Cyclin D/Cdk4 stimulates progression through the G1-S phase of the cell cycle in many organisms. In Drosophila, Cyclin D/Cdk4 also induces cell growth independently of cell cycle progression. In this issue of Developmental Cell, Frei and Edgar reveal that Cyclin D/Cdk4-stimulated growth requires Hph, a p...

journal_title：Developmental cell

authors： Duronio RJ

更新日期：2004-02-01 00:00:00

abstract：:Developmental growth requires coordination between the growth rates of individual tissues and organs. Here, we examine how Drosophila neuromuscular synapses grow to match the size of their target muscles. We show that changes in muscle growth driven by autonomous modulation of insulin receptor signaling produce corres...

journal_title：Developmental cell

authors： Ho CH,Treisman JE

更新日期：2020-07-06 00:00:00

abstract：:We present the Real-time Accurate Cell-shape Extractor (RACE), a high-throughput image analysis framework for automated three-dimensional cell segmentation in large-scale images. RACE is 55-330 times faster and 2-5 times more accurate than state-of-the-art methods. We demonstrate the generality of RACE by extracting c...

journal_title：Developmental cell

authors： Stegmaier J,Amat F,Lemon WC,McDole K,Wan Y,Teodoro G,Mikut R,Keller PJ

更新日期：2016-01-25 00:00:00

abstract：:Enhancers are the primary determinants of cell identity, but the regulatory components controlling enhancer turnover during lineage commitment remain largely unknown. Here we compare the enhancer landscape, transcriptional factor occupancy, and transcriptomic changes in human fetal and adult hematopoietic stem/progeni...

journal_title：Developmental cell

authors： Huang J,Liu X,Li D,Shao Z,Cao H,Zhang Y,Trompouki E,Bowman TV,Zon LI,Yuan GC,Orkin SH,Xu J

更新日期：2016-01-11 00:00:00

abstract：:The capacity to undergo meiosis defines vertebrate germ cells, yet mechanisms driving initiation of this specialized process are largely undefined. In this issue of Developmental Cell,Ishiguro et al. (2020) identified the transcription factor MEIOSIN as a gatekeeper of meiotic initiation in both male and female germ c...

journal_title：Developmental cell

authors： Oatley JM,Griswold MD

更新日期：2020-02-24 00:00:00

abstract：:The developmental mechanisms that orchestrate differentiation of specific nephron segments are incompletely understood, and the factors that maintain their terminal differentiation after nephrogenesis remain largely unknown. Here, the transcription factor AP-2β is shown to be required for the differentiation of distal...

journal_title：Developmental cell

authors： Marneros AG

更新日期：2020-08-10 00:00:00