Stopped in translation: EMT control meets eukaryotic elongation.

Abstract:

:Recently reporting in Molecular Cell, Hussey et al. (2011) find that hnRNP E1 inhibits the translation of several genes essential for the epithelial-to-mesenchymal transition (EMT) by blocking eEF1A1 release during translation elongation. Phosphorylation of hnRNP E1 in response to TGF-β signaling disrupts the hnRNP E1-eEF1A1 interaction, triggering EMT.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Zhang YE

doi

10.1016/j.devcel.2011.02.012

subject

Has Abstract

pub_date

2011-03-15 00:00:00

pages

289-90

issue

3

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(11)00081-5

journal_volume

20

pub_type

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