Abstract：
:Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional corepressors of the Snail family via an interaction with the SNAG domain. Ajuba LIM proteins interact with Snail in the nucleus on endogenous E-cadherin promoters and contribute to Snail-dependent repression of E-cadherin. Using Xenopus neural crest as a model of in vivo Snail- or Slug-induced EMT, we demonstrate that Ajuba LIM proteins contribute to neural crest development as Snail/Slug corepressors and are required for in vivo Snail/Slug function. Because Ajuba LIM proteins are also components of adherens junctions and contribute to their assembly or stability, their functional interaction with Snail proteins in the nucleus suggests that Ajuba LIM proteins are important regulators of epithelia dynamics communicating surface events with nuclear responses.
journal_name
Dev Celljournal_title
Developmental cellauthors
Langer EM,Feng Y,Zhaoyuan H,Rauscher FJ 3rd,Kroll KL,Longmore GDdoi
10.1016/j.devcel.2008.01.005subject
Has Abstractpub_date
2008-03-01 00:00:00pages
424-36issue
3eissn
1534-5807issn
1878-1551pii
S1534-5807(08)00033-6journal_volume
14pub_type
杂志文章abstract：:In this issue of Developmental Cell, Weavers and Skaer (2013) show that interplay between two opposing forces generated by tip cell attachment to muscles and migration of kink cells allows for the formation of the looped shape and positioning of renal tubules within the body of a fly larva. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
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pub_type： 评论,杂志文章
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pub_type： 杂志文章
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journal_title：Developmental cell
pub_type： 杂志文章
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