Abstract：
:In Drosophila, left/right (LR) asymmetry is apparent in the directional looping of the gut and male genitalia. The dextral orientation of the organs depends on the activity of a single gene, MyosinID (myoID), whose mutation leads to a fully inverted LR axis, thus revealing the activity of a recessive sinistral pathway. Here, we present the identification of the Hox gene Abdominal-B (Abd-B) as an upstream regulator of LR determination. This role appears distinct from its function in anteroposterior patterning. We show that the Abd-Bm isoform binds to regulatory sequences of myoID and controls MyoID expression in the organ LR organizer. Abd-Bm is also required for the sinistral pathway. Thus, when Abd-B activity is missing, no symmetry breaking occurs and flies develop symmetrically. These findings identify the Hox gene Abd-B as directing the earliest events of LR asymmetry establishment in Drosophila.
journal_name
Dev Celljournal_title
Developmental cellauthors
Coutelis JB,Géminard C,Spéder P,Suzanne M,Petzoldt AG,Noselli Sdoi
10.1016/j.devcel.2012.11.013subject
Has Abstractpub_date
2013-01-14 00:00:00pages
89-97issue
1eissn
1534-5807issn
1878-1551pii
S1534-5807(12)00533-3journal_volume
24pub_type
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