Temporal coordinates: the genes that fix cell fate with birth order.

abstract：:Drosophila gurken mRNA is localized by dynein-mediated transport to a crescent near the oocyte nucleus, thus targeting the TGFalpha signal and forming the primary embryonic axes. Here, we show that gurken and the I factor, a non-LTR retrotransposon, share a small consensus RNA stem loop of defined secondary structure,...

journal_title：Developmental cell

authors： Van De Bor V,Hartswood E,Jones C,Finnegan D,Davis I

更新日期：2005-07-01 00:00:00

abstract：:Translation of ribosomal protein-coding mRNAs (RP-mRNAs) constitutes a key step in ribosome biogenesis, but the mechanisms that modulate RP-mRNA translation in coordination with other cellular processes are poorly defined. Here, we show that subcellular localization of RP-mRNAs acts as a key regulator of their transla...

journal_title：Developmental cell

authors： Dermit M,Dodel M,Lee FCY,Azman MS,Schwenzer H,Jones JL,Blagden SP,Ule J,Mardakheh FK

更新日期：2020-11-09 00:00:00

abstract：:Auxins are a class of phytohormones implicated in virtually every aspect of plant growth and development. Many early plant responses to auxin are apparently mediated by members of a family of Aux/IAA proteins that dimerize with and inhibit members of the auxin response factor (ARF) family of transcription factors. Aux...

journal_title：Developmental cell

authors： Rogg LE,Bartel B

更新日期：2001-11-01 00:00:00

abstract：:Prior to the pairing and recombination between homologous chromosomes during meiosis, telomeres attach to the nuclear envelope and form a transient cluster. However, the protein factors mediating meiotic telomere attachment to the nuclear envelope and the requirement of this attachment for homolog pairing and synapsis...

journal_title：Developmental cell

authors： Ding X,Xu R,Yu J,Xu T,Zhuang Y,Han M

更新日期：2007-06-01 00:00:00

abstract：:Dystroglycan localizes to the basal domain of epithelial cells and has been reported to play a role in apical-basal polarity. Here, we show that Dystroglycan null mutant follicle cells have normal apical-basal polarity, but lose the planar polarity of their basal actin stress fibers, a phenotype it shares with Dystrop...

journal_title：Developmental cell

authors： Mirouse V,Christoforou CP,Fritsch C,St Johnston D,Ray RP

更新日期：2009-01-01 00:00:00

abstract：:Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through Piwi-associated RNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains unclear whether it plays any roles in early GSC...

journal_title：Developmental cell

authors： Ma X,Zhu X,Han Y,Story B,Do T,Song X,Wang S,Zhang Y,Blanchette M,Gogol M,Hall K,Peak A,Anoja P,Xie T

更新日期：2017-04-24 00:00:00

abstract：:DSL ligands promote proteolysis of the Notch receptor, to release active Notch intracellular domain (N(ICD)). Conversely, the E3 ubiquitin ligase Deltex can activate ligand-independent Notch proteolysis and signaling. Here we show that Deltex effects require endocytic trafficking by HOPS and AP-3 complexes. Our data s...

journal_title：Developmental cell

authors： Wilkin M,Tongngok P,Gensch N,Clemence S,Motoki M,Yamada K,Hori K,Taniguchi-Kanai M,Franklin E,Matsuno K,Baron M

更新日期：2008-11-01 00:00:00

abstract：:hunchback regulates the temporal identity of neuroblasts in Drosophila. Here we show that hbl-1, the C. elegans hunchback ortholog, also controls temporal patterning. Furthermore, hbl-1 is a probable target of microRNA regulation through its 3'UTR. hbl-1 loss-of-function causes the precocious expression of adult seam ...

journal_title：Developmental cell

authors： Lin SY,Johnson SM,Abraham M,Vella MC,Pasquinelli A,Gamberi C,Gottlieb E,Slack FJ

更新日期：2003-05-01 00:00:00

abstract：:The orientation of the mitotic spindle plays a key role in determining whether a polarized cell will divide symmetrically or asymmetrically. In most cell types, cytoplasmic dynein plays a critical role in spindle orientation. However, how dynein directs opposite spindle poles toward distinct and predetermined cell end...

journal_title：Developmental cell

authors： Grava S,Schaerer F,Faty M,Philippsen P,Barral Y

更新日期：2006-04-01 00:00:00

abstract：:We present the Real-time Accurate Cell-shape Extractor (RACE), a high-throughput image analysis framework for automated three-dimensional cell segmentation in large-scale images. RACE is 55-330 times faster and 2-5 times more accurate than state-of-the-art methods. We demonstrate the generality of RACE by extracting c...

journal_title：Developmental cell

authors： Stegmaier J,Amat F,Lemon WC,McDole K,Wan Y,Teodoro G,Mikut R,Keller PJ

更新日期：2016-01-25 00:00:00

abstract：:Cells commit to mitosis by abruptly activating the mitotic cyclin-Cdk complexes. During Drosophila gastrulation, mitosis is associated with the transcriptional activation of cdc25(string), a phosphatase that activates Cdk1. Here, we demonstrate that the switch-like entry into mitosis observed in the Drosophila embryo ...

journal_title：Developmental cell

authors： Di Talia S,Wieschaus EF

更新日期：2012-04-17 00:00:00

abstract：:Epithelial tubes are found in many vital organs and require uniform and correct tube diameters for optimal function. Tube size depends on apical membrane growth and subapical cytoskeletal reorganization, but the cues that coordinate these events to ensure functional tube shape remain elusive. We find that epithelial t...

journal_title：Developmental cell

authors： Tonning A,Hemphälä J,Tång E,Nannmark U,Samakovlis C,Uv A

更新日期：2005-09-01 00:00:00

abstract：:In organellogenesis of the chloroplast from endosymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should have been pivotal. However, it is still mysterious how these mechanisms were established and how they work in plant cells. Here we show that AKR2A, the cytosolic targetin...

journal_title：Developmental cell

authors： Kim DH,Park MJ,Gwon GH,Silkov A,Xu ZY,Yang EC,Song S,Song K,Kim Y,Yoon HS,Honig B,Cho W,Cho Y,Hwang I

更新日期：2014-09-08 00:00:00

abstract：:The emergence of limb-driven locomotor behaviors was a key event in the evolution of vertebrates and fostered the transition from aquatic to terrestrial life. We show that the generation of limb-projecting lateral motor column (LMC) neurons in mice relies on a transcriptional autoregulatory module initiated via transi...

journal_title：Developmental cell

authors： Jung H,Mazzoni EO,Soshnikova N,Hanley O,Venkatesh B,Duboule D,Dasen JS

更新日期：2014-04-28 00:00:00

abstract：:Formation of the embryonic heart tube requires the medial migration and merger of bilateral precursor populations. A new study of zebrafish cardiogenesis published in this issue of Developmental Cell indicates that precursor migration involves formation of a coherent epithelium and that fibronectin plays an important ...

journal_title：Developmental cell

authors： Glickman NS,Yelon D

更新日期：2004-03-01 00:00:00

abstract：:Zebrafish heart regeneration occurs through the activation of cardiomyocyte proliferation in areas of trauma. Here, we show that within 3 hr of ventricular injury, the entire endocardium undergoes morphological changes and induces expression of the retinoic acid (RA)-synthesizing enzyme raldh2. By one day posttrauma, ...

journal_title：Developmental cell

authors： Kikuchi K,Holdway JE,Major RJ,Blum N,Dahn RD,Begemann G,Poss KD

更新日期：2011-03-15 00:00:00

abstract：:The effect of intracellular vesicle trafficking on stem-cell behavior is largely unexplored. We screened the Drosophila sorting nexins (SNXs) and discovered that one, SH3PX1, profoundly affects gut homeostasis and lifespan. SH3PX1 restrains intestinal stem cell (ISC) division through an endocytosis-autophagy network t...

journal_title：Developmental cell

authors： Zhang P,Holowatyj AN,Roy T,Pronovost SM,Marchetti M,Liu H,Ulrich CM,Edgar BA

更新日期：2019-05-20 00:00:00

abstract：:Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively stud...

journal_title：Developmental cell

authors： Curran S,Strandkvist C,Bathmann J,de Gennes M,Kabla A,Salbreux G,Baum B

更新日期：2017-11-20 00:00:00

abstract：:Germ cells, the cells that give rise to sperm and egg, maintain the potential to recreate all cell types in a new individual. This wide developmental potential, or totipotency, is manifested in unusual tumors called teratomas, in which germ cells undergo somatic differentiation. Although recent studies have implicated...

journal_title：Developmental cell

authors： Biedermann B,Wright J,Senften M,Kalchhauser I,Sarathy G,Lee MH,Ciosk R

更新日期：2009-09-01 00:00:00

abstract：:The faithful alignment of homologous chromosomes during meiotic prophase requires the coordination of DNA double-strand break (DSB) repair with large-scale chromosome reorganization. Here we identify the phosphatase PP4 (Pph3/Psy2) as a mediator of this process in Saccharomyces cerevisiae. In pp4 mutants, early stages...

journal_title：Developmental cell

authors： Falk JE,Chan AC,Hoffmann E,Hochwagen A

更新日期：2010-10-19 00:00:00

abstract：:Caspase proteases execute apoptosis but also function in development. In this issue of Developmental Cell, Weaver et al. report that C. elegans CED-3 caspase promotes animal growth through PMK-1/p38 kinase cleavage, and at the expense of pathogen and stress immunity, revealing an unexpected homeostatic relationship be...

journal_title：Developmental cell

authors： Yarychkivska O,Shaham S

更新日期：2020-05-04 00:00:00

abstract：:The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad ...

journal_title：Developmental cell

authors： Langevin J,Morgan MJ,Sibarita JB,Aresta S,Murthy M,Schwarz T,Camonis J,Bellaïche Y

更新日期：2005-09-01 00:00:00

abstract：:Hox proteins gain specificity by interacting with TALE-class cofactors. In a recent issue of Cell and in this issue of Developmental Cell, Crocker et al. (2015) and Amin et al. (2015), respectively, demonstrate that non-canonical Hox/TALE binding sequences play a major role in the regionalized regulation of target gen...

journal_title：Developmental cell

authors： Merabet S,Lohmann I

更新日期：2015-02-09 00:00:00

abstract：:Dynamic rearrangements of the actin cytoskeleton play a key role in numerous cellular processes. In Drosophila, fusion between a muscle founder cell and a fusion competent myoblast (FCM) is mediated by an invasive, F-actin-enriched podosome-like structure (PLS). Here, we show that the dynamics of the PLS is controlled...

journal_title：Developmental cell

authors： Jin P,Duan R,Luo F,Zhang G,Hong SN,Chen EH

更新日期：2011-05-17 00:00:00

abstract：:Apoptosis has been implicated in compensatory proliferation signaling (CPS), whereby dying cells induce proliferation in neighboring cells as a means to restore homeostasis. The nature of signaling between apoptotic cells and their neighboring cells remains largely unknown. Here we show that a fraction of apoptotic ce...

journal_title：Developmental cell

authors： Gupta KH,Goldufsky JW,Wood SJ,Tardi NJ,Moorthy GS,Gilbert DZ,Zayas JP,Hahm E,Altintas MM,Reiser J,Shafikhani SH

更新日期：2017-06-19 00:00:00

abstract：:The chemokine CXCL12 and its receptor CXCR4 have many functions during embryonic and post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling in cardiac development and found that embryonic Cxcl12-null hearts lacked intra-ventricular coronary arteries (CAs) and exhibited absent or mispl...

journal_title：Developmental cell

authors： Ivins S,Chappell J,Vernay B,Suntharalingham J,Martineau A,Mohun TJ,Scambler PJ

更新日期：2015-05-26 00:00:00

abstract：:The Decapentaplegic and Notch signaling pathways are thought to direct regional specification in the Drosophila eye-antennal epithelium by controlling the expression of selector genes for the eye (Eyeless/Pax6, Eyes absent) and/or antenna (Distal-less). Here, we investigate the function of these signaling pathways in ...

journal_title：Developmental cell

authors： Kenyon KL,Ranade SS,Curtiss J,Mlodzik M,Pignoni F

更新日期：2003-09-01 00:00:00

abstract：:We use the Dpp morphogen gradient in the Drosophila wing disc as a model to address the fundamental question of how a gradient of a growth factor can produce uniform growth. We first show that proper expression and subcellular localization of components in the Fat tumor-suppressor pathway, which have been argued to de...

journal_title：Developmental cell

authors： Schwank G,Tauriello G,Yagi R,Kranz E,Koumoutsakos P,Basler K

更新日期：2011-01-18 00:00:00

abstract：:The role of mitochondria in Drosophila programmed cell death remains unclear, although certain gene products that regulate cell death seem to be evolutionarily conserved. We find that developmental programmed cell death stimuli in vivo and multiple apoptotic stimuli ex vivo induce dramatic mitochondrial fragmentation ...

journal_title：Developmental cell

authors： Goyal G,Fell B,Sarin A,Youle RJ,Sriram V

更新日期：2007-05-01 00:00:00

abstract：:Exposure to environmental teratogenic pollutant leads to severe birth defects. However, the biological events underlying these developmental abnormalities remain undefined. Here, we report a molecular link between an environmental stress response pathway and key developmental genes during craniofacial development. Str...

journal_title：Developmental cell

authors： Zalc A,Rattenbach R,Auradé F,Cadot B,Relaix F

更新日期：2015-04-06 00:00:00