Abstract:
:In Drosophila, commitment of a cell to a sense organ precursor (SOP) fate requires bHLH proneural transcription factor upregulation, a process that depends in most cases on the interplay of proneural gene autoregulation and inhibitory Notch signaling. A subset of SOPs are selected by a recruitment pathway involving EGFR signaling to ectodermal cells expressing the proneural gene atonal. We show that EGFR signaling drives recruitment by directly facilitating atonal autoregulation. Pointed, the transcription factor that mediates EGFR signaling, and Atonal protein itself bind cooperatively to adjacent conserved binding sites in an atonal enhancer. Recruitment is therefore contingent on the combined presence of Atonal protein (providing competence) and EGFR signaling (triggering recruitment). Thus, autoregulation is the nodal control point targeted by signaling. This exemplifies a simple and general mechanism for regulating the transition from competence to cell fate commitment whereby a cell signal directly targets the autoregulation of a selector gene.
journal_name
Dev Celljournal_title
Developmental cellauthors
zur Lage PI,Powell LM,Prentice DR,McLaughlin P,Jarman APdoi
10.1016/j.devcel.2004.09.015keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
687-96issue
5eissn
1534-5807issn
1878-1551pii
S1534-5807(04)00361-2journal_volume
7pub_type
杂志文章abstract::COPII vesicles assemble at ER subdomains called transitional ER (tER) sites, but the mechanism that generates tER sites is unknown. To study tER biogenesis, we analyzed the transmembrane protein Sec12, which initiates COPII vesicle formation. Sec12 is concentrated at discrete tER sites in the budding yeast Pichia past...
journal_title:Developmental cell
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journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2013.07.004
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abstract::The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell abl...
journal_title:Developmental cell
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abstract::Transcriptional mediators of cell stress pathways, including HIF1α, ATF4, and p53, are key to normal development and play critical roles in disease, including ischemia and cancer. Despite their importance, mechanisms by which pathways mediated by these transcription factors interact with one another are not fully unde...
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doi:10.1016/j.devcel.2015.04.021
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journal_title:Developmental cell
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doi:10.1016/j.devcel.2019.10.016
更新日期:2019-12-16 00:00:00
abstract::Optimal cell performance depends on cell size and the appropriate relative size, i.e., scaling, of the nucleus. How nuclear scaling is regulated and contributes to cell function is poorly understood, especially in skeletal muscle fibers, which are among the largest cells, containing hundreds of nuclei. Here, we presen...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.02.020
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journal_title:Developmental cell
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doi:10.1016/j.devcel.2009.12.013
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pub_type: 杂志文章
doi:10.1016/j.devcel.2017.03.023
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.05.024
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abstract::The cytoplasm is not a homogenous solution but instead consists of large dynamic assemblies that arise from transient molecular interactions. Some of these structures have been shown to represent liquid droplets of concentrated protein and RNA. Liquid phase separation of cytoplasm may be a fundamental principle of cyt...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.06.013
更新日期:2011-07-19 00:00:00
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journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2013.07.018
更新日期:2013-08-12 00:00:00
abstract::Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.11.016
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.01.028
更新日期:2020-04-06 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.07.027
更新日期:2014-10-13 00:00:00
abstract::Genome condensation during mitosis presents a chromatin landscape largely inaccessible to RNA polymerase II and most transcription factors. Caravaca et al. (2013) now report in Genes and Development that the pioneer transcription factor FOXA1 is retained at mitotic chromosomes, bookmarking the genome to enable gene ex...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2013.02.005
更新日期:2013-02-25 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2009.05.010
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journal_title:Developmental cell
pub_type: 杂志文章,评审
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journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.11.021
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.09.008
更新日期:2016-09-26 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.07.023
更新日期:2018-09-24 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.06.001
更新日期:2016-07-11 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2004.08.014
更新日期:2004-09-01 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.02.003
更新日期:2014-03-10 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.11.016
更新日期:2020-12-07 00:00:00