Abstract:
:We show that Rap2, a member of the Ras GTPase family, positively regulates Activin/Nodal signaling activity by controlling the trafficking of its receptors. In the absence of ligand activation, Rap2 directs internalized Activin/Nodal receptors into a recycling pathway, thereby preventing their degradation and maintaining their levels on the cell surface. Upon ligand activation, Rap2 no longer promotes receptor recycling but delays its turnover. In both cases, Rap2 contributes to upregulation of signaling activity by antagonizing Smad7. In addition, we found that the efficiency of Activin/Nodal receptor recycling is different between dorsal and ventral halves of Xenopus early embryo, which results from the asymmetric expression of Rap2 and Smad7. Consequently, they regulate cell responsiveness to ligands and the spatiotemporally dynamic activation of Smad2 along the dorsoventral axis of the embryo. Therefore, these findings suggest a molecular basis for the regulation of signaling activity and embryonic patterning by Activin/Nodal receptor trafficking.
journal_name
Dev Celljournal_title
Developmental cellauthors
Choi SC,Kim GH,Lee SJ,Park E,Yeo CY,Han JKdoi
10.1016/j.devcel.2008.05.004subject
Has Abstractpub_date
2008-07-01 00:00:00pages
49-61issue
1eissn
1534-5807issn
1878-1551pii
S1534-5807(08)00204-9journal_volume
15pub_type
杂志文章abstract::Odorant receptors (ORs) in the olfactory epithelium bind to volatile small molecules leading to the perception of smell. ORs are expressed in many tissues but their functions are largely unknown. We show multiple ORs display distinct mRNA expression patterns during myogenesis in vitro and muscle regeneration in vivo. ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2009.09.004
更新日期:2009-11-01 00:00:00
abstract::In response to cellular stress, mitochondria remodel their structure by organelle division and fusion. In this issue of Developmental Cell, Cooper et al. (2014) report that a nuclear protein, cyclin C, is recruited from nuclei to mitochondria upon oxidative stress and promotes mitochondrial division and apoptosis of t...
journal_title:Developmental cell
pub_type: 评论,杂志文章
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abstract::Axillary meristems (AMs) give rise to lateral shoots and are critical to plant architecture. Understanding how developmental cues and environmental signals impact AM development will enable the improvement of plant architecture in agriculture. Here, we show that ARGONAUTE10 (AGO10), which sequesters miR165/166, promot...
journal_title:Developmental cell
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abstract::22q11 deletion (del22q11) syndrome is characterized genetically by heterozygous deletions within chromosome 22q11 and clinically by a constellation of congenital malformations of the aortic arch, heart, thymus, and parathyroid glands described as DiGeorge syndrome (DGS). Here, we report that compound heterozygosity of...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.12.002
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abstract::Reporting in Cell, Berg et al. (2016) reveal a connection between genetic lysosomal storage disorders and the ability of macrophages to migrate and control mycobacterial infection. This insight, resulting from a zebrafish genetic screen, inspired the authors to propose an explanation for the increased susceptibility o...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2016.04.004
更新日期:2016-04-18 00:00:00
abstract::Signaling circuits often coordinate cellular membranes and actin filaments at distinct sites to direct cell behavior. In this issue of Developmental Cell, Bershteyn et al. outline how the molecular scaffold protein, MIM, which bends membranes and binds actin filaments, is at the middle of one such circuit to regulate ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
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abstract::In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2019.05.030
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.06.015
更新日期:2015-08-24 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2009.04.011
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.12.015
更新日期:2013-02-11 00:00:00
abstract::The role of Lefty2 in left-right patterning was investigated by analysis of mutant mice that lack asymmetric expression of lefty2. These animals exhibited various situs defects including left isomerism. The asymmetric expression of nodal was prolonged and the expression of Pitx2 was upregulated in the mutant embryos. ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(01)00006-5
更新日期:2001-07-01 00:00:00
abstract::Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players. ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00298-3
更新日期:2003-10-01 00:00:00
abstract::Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2017.10.001
更新日期:2017-11-20 00:00:00
abstract::RhoA stimulates cell contractility by recruiting downstream effectors to the cortical plasma membrane. We now show that direct binding by anillin is required for effective signaling: this antagonizes the otherwise labile membrane association of GTP-RhoA to promote effector recruitment. However, since its binding to Rh...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.04.031
更新日期:2019-06-17 00:00:00
abstract::A central enigma in epigenetics is how epigenetic factors are guided to specific genomic sites for their function. Previously, we reported that a Piwi-piRNA complex associates with the piRNA-complementary site in the Drosophila genome and regulates its epigenetic state. Here, we report that Piwi-piRNA complexes bind t...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.01.023
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abstract::Pontin and reptin are conserved AAA+ ATPases identified in chromatin-remodeling complexes. In a recent issue of Cell, Venteicher et al. provide new insight into the function of pontin and reptin in telomerase biogenesis, which is important for cellular senescence, aging, and cancer. These unexpected findings have impl...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.03.018
更新日期:2008-04-01 00:00:00
abstract::Centrosomes are important cell organizers. They consist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically during mitosis-a process termed centrosome maturation. How centrosomes mature remains mysterious. Here, we identify a domain in Drosophila Cnn that appears to be phospho...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.02.013
更新日期:2014-03-31 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2010.01.011
更新日期:2010-02-16 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2004.12.005
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pub_type: 杂志文章,评审
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journal_title:Developmental cell
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pub_type: 杂志文章
doi:10.1016/j.devcel.2011.09.014
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.01.002
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abstract::The nervous system is enormously complex, yet the number of cues that control axonal growth is surprisingly meager. Posttranslational modifications amplify diversity, but the degree to which they are employed is unclear. Here, we show that Furin and SKI-1 combine with autocatalytic cleavage and a disulfide bridge to g...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.11.022
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(01)00084-3
更新日期:2001-11-01 00:00:00
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journal_title:Developmental cell
pub_type: 评论,杂志文章,评审
doi:10.1016/s1534-5807(03)00066-2
更新日期:2003-03-01 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.06.027
更新日期:2011-08-16 00:00:00
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journal_title:Developmental cell
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doi:10.1016/j.devcel.2017.01.007
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abstract::Cells entering mitosis become rounded, lose attachment to the substrate, and increase their cortical rigidity. Pivotal to these events is the dismantling of focal adhesions (FAs). How mitotic reshaping is linked to commitment to divide is unclear. Here, we show that DEPDC1B, a protein that accumulates in G2, coordinat...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.09.009
更新日期:2014-11-24 00:00:00
abstract::During organogenesis, coherent organ growth arises from spatiotemporally coordinated decisions of individual cells. In the root of Arabidopsis thaliana, this coordination results in the establishment of a division and a differentiation zone. Cells continuously move through these zones; thus, a major question is how th...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.04.004
更新日期:2020-05-18 00:00:00