当前位置： SCI文献检索 > DEVELOPMENTAL CELL期刊下所有文献 > Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.

Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.

Abstract：

:The role of Lefty2 in left-right patterning was investigated by analysis of mutant mice that lack asymmetric expression of lefty2. These animals exhibited various situs defects including left isomerism. The asymmetric expression of nodal was prolonged and the expression of Pitx2 was upregulated in the mutant embryos. The absence of Lefty2 conferred on Nodal the ability to diffuse over a long distance. Thus, Nodal-responsive genes, including Pitx2, that are normally expressed on the left side were expressed bilaterally in the mutant embryos, even though nodal expression was confined to the left side. These results suggest that Nodal is a long-range signaling molecule but that its range of action is normally limited by the feedback inhibitor Lefty2.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Meno C,Takeuchi J,Sakuma R,Koshiba-Takeuchi K,Ohishi S,Saijoh Y,Miyazaki J,ten Dijke P,Ogura T,Hamada H

doi

10.1016/s1534-5807(01)00006-5

keywords:

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

127-38

issue

1

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(01)00006-5

journal_volume

1

pub_type

杂志文章

相关文献

DEVELOPMENTAL CELL文献大全
  • Interplay between the dividing cell and its neighbors regulates adherens junction formation during cytokinesis in epithelial tissue.

    abstract：:How adherens junctions (AJs) are formed upon cell division is largely unexplored. Here, we found that AJ formation is coordinated with cytokinesis and relies on an interplay between the dividing cell and its neighbors. During contraction of the cytokinetic ring, the neighboring cells locally accumulate Myosin II and p...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2012.11.019

    authors： Herszterg S,Leibfried A,Bosveld F,Martin C,Bellaiche Y

    更新日期：2013-02-11 00:00:00

  • Reaching a genetic and molecular understanding of skeletal development.

    abstract：:In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes an...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/s1534-5807(02)00157-0

    authors： Karsenty G,Wagner EF

    更新日期：2002-04-01 00:00:00

  • Planar Differential Growth Rates Initiate Precise Fold Positions in Complex Epithelia.

    abstract：:Tissue folding is a fundamental process that shapes epithelia into complex 3D organs. The initial positioning of folds is the foundation for the emergence of correct tissue morphology. Mechanisms forming individual folds have been studied, but the precise positioning of folds in complex, multi-folded epithelia is less...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2019.09.009

    authors： Tozluoǧlu M,Duda M,Kirkland NJ,Barrientos R,Burden JJ,Muñoz JJ,Mao Y

    更新日期：2019-11-04 00:00:00

  • GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion.

    abstract：:TC10, a Rho family GTPase, has been shown to play an important role in the exocytosis of GLUT4 and other proteins, primarily by tethering the vesicles at the plasma membrane. Using a newly developed probe based on fluorescence resonance energy transfer, we found that TC10 activity at tethered vesicles dropped immediat...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2006.07.008

    authors： Kawase K,Nakamura T,Takaya A,Aoki K,Namikawa K,Kiyama H,Inagaki S,Takemoto H,Saltiel AR,Matsuda M

    更新日期：2006-09-01 00:00:00

  • Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles.

    abstract：:Apoptosis has been implicated in compensatory proliferation signaling (CPS), whereby dying cells induce proliferation in neighboring cells as a means to restore homeostasis. The nature of signaling between apoptotic cells and their neighboring cells remains largely unknown. Here we show that a fraction of apoptotic ce...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2017.05.014

    authors： Gupta KH,Goldufsky JW,Wood SJ,Tardi NJ,Moorthy GS,Gilbert DZ,Zayas JP,Hahm E,Altintas MM,Reiser J,Shafikhani SH

    更新日期：2017-06-19 00:00:00

  • Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion.

    abstract：:Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H₂O₂)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly w...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2010.12.007

    authors： DeGennaro M,Hurd TR,Siekhaus DE,Biteau B,Jasper H,Lehmann R

    更新日期：2011-02-15 00:00:00

  • ESCRT-III/Vps4 Controls Heterochromatin-Nuclear Envelope Attachments.

    abstract：:Eukaryotic genomes are organized within the nucleus through interactions with inner nuclear membrane (INM) proteins. How chromatin tethering to the INM is controlled in interphase and how this process contributes to subsequent mitotic nuclear envelope (NE) remodeling remains unclear. We have probed these fundamental q...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2020.01.028

    authors： Pieper GH,Sprenger S,Teis D,Oliferenko S

    更新日期：2020-04-06 00:00:00

  • Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.

    abstract：:It is intuitive to speculate that nutrient availability may influence differentiation of mammalian cells. Nonetheless, a comprehensive complement of the molecular determinants involved in this process has not been elucidated yet. Here, we have investigated how nutrients (glucose) affect skeletal myogenesis. Glucose re...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2008.02.004

    authors： Fulco M,Cen Y,Zhao P,Hoffman EP,McBurney MW,Sauve AA,Sartorelli V

    更新日期：2008-05-01 00:00:00

  • BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.

    abstract：:BMP signaling is essential for promoting self-renewal of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell proliferation in the mouse intestine and skin. However, it remains unknown whether BMP signaling can promote self-renewal of adult somatic stem cells. In this study, we sh...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2005.09.013

    authors： Kirilly D,Spana EP,Perrimon N,Padgett RW,Xie T

    更新日期：2005-11-01 00:00:00

  • Adapting to Barriers: Glial Septate Junctions Stretch to Keep Up.

    abstract：:The blood brain barrier (BBB) is critical to ensure proper nervous system function and organismal health. In this issue of Developmental Cell, Babatz and colleagues explore the mechanisms of BBB maintenance and uncover a potential evolutionary link by which BBB glia construct paracellular barriers to ensure uninterrup...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2018.11.036

    authors： Coutinho-Budd J

    更新日期：2018-12-17 00:00:00

  • Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.

    abstract：:Hedgehog (Hh) signaling during development and in postembryonic tissues requires activation of the 7TM oncoprotein Smoothened (Smo) by mechanisms that may involve endogenous lipidic modulators. Exogenous Smo ligands previously identified include the plant sterol cyclopamine (and its therapeutically useful synthetic mi...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2013.07.015

    authors： Myers BR,Sever N,Chong YC,Kim J,Belani JD,Rychnovsky S,Bazan JF,Beachy PA

    更新日期：2013-08-26 00:00:00

  • Keeping in Touch to Differentiate.

    abstract：:During zebrafish gastrulation, mesendoderm progenitor cells differentiate to mesoderm or endoderm cells. In this issue of Developmental Cell, Barone and colleagues (2017) show that the interplay between cell-cell contact duration and morphogen signaling can control this fate segregation, providing a new framework for ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2017.10.006

    authors： Chan CJ,Hiiragi T

    更新日期：2017-10-23 00:00:00

  • Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction.

    abstract：:Heparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes. Here, we show that the transmembrane protein, Nogo-A, inhibits neurite outgrowth and cell spreading in neurons and Nogo-A-responsive cell lines via HSPGs. The extracellular, active 180 amino acid Nogo-A regio...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2017.08.014

    authors： Kempf A,Boda E,Kwok JCF,Fritz R,Grande V,Kaelin AM,Ristic Z,Schmandke A,Schmandke A,Tews B,Fawcett JW,Pertz O,Buffo A,Schwab ME

    更新日期：2017-10-09 00:00:00

  • Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response.

    abstract：:Small repeat-associated siRNAs (rasiRNAs) mediate silencing of retrotransposons and the Stellate locus. Mutations in the Drosophila rasiRNA pathway genes armitage and aubergine disrupt embryonic axis specification, triggering defects in microtubule polarization as well as asymmetric localization of mRNA and protein de...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2006.12.001

    authors： Klattenhoff C,Bratu DP,McGinnis-Schultz N,Koppetsch BS,Cook HA,Theurkauf WE

    更新日期：2007-01-01 00:00:00

  • Proteostatic hotspots in amyloid fibrils protect us from neurodegeneration.

    abstract：:Alzheimer's disease remains a formidable challenge for therapeutic management. In a recent report in Nature Structural and Molecular Biology, Cohen et al. (2015) present intriguing results showing that "designer" molecular chaperones may hold the key to an evolutionarily conserved program for management of toxic oligo...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2015.03.009

    authors： Singh JK,Balch WE

    更新日期：2015-03-23 00:00:00

  • CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.

    abstract：:CLASPs are mammalian microtubule-stabilizing proteins that can mediate the interaction between distal microtubule ends and the cell cortex. Using mass spectrometry-based assays, we have identified two CLASP partners, LL5beta and ELKS. LL5beta and ELKS form a complex that colocalizes with CLASPs at the cortex of HeLa c...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2006.05.012

    authors： Lansbergen G,Grigoriev I,Mimori-Kiyosue Y,Ohtsuka T,Higa S,Kitajima I,Demmers J,Galjart N,Houtsmuller AB,Grosveld F,Akhmanova A

    更新日期：2006-07-01 00:00:00

  • Tugging organs into place.

    abstract：:In this issue of Developmental Cell, Weavers and Skaer (2013) show that interplay between two opposing forces generated by tip cell attachment to muscles and migration of kink cells allows for the formation of the looped shape and positioning of renal tubules within the body of a fly larva. ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2013.10.021

    authors： Lenard A,Affolter M

    更新日期：2013-11-11 00:00:00

  • GOLVEN secretory peptides regulate auxin carrier turnover during plant gravitropic responses.

    abstract：:Growth and development are coordinated by an array of intercellular communications. Known plant signaling molecules include phytohormones and hormone peptides. Although both classes can be implicated in the same developmental processes, little is known about the interplay between phytohormone action and peptide signal...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2012.02.002

    authors： Whitford R,Fernandez A,Tejos R,Pérez AC,Kleine-Vehn J,Vanneste S,Drozdzecki A,Leitner J,Abas L,Aerts M,Hoogewijs K,Baster P,De Groodt R,Lin YC,Storme V,Van de Peer Y,Beeckman T,Madder A,Devreese B,Luschnig C,Friml

    更新日期：2012-03-13 00:00:00

  • External mechanical cues trigger the establishment of the anterior-posterior axis in early mouse embryos.

    abstract：:Mouse anterior-posterior axis polarization is preceded by formation of the distal visceral endoderm (DVE) by unknown mechanisms. Here, we show by in vitro culturing of embryos immediately after implantation in microfabricated cavities that the external mechanical cues exerted on the embryo are crucial for DVE formatio...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2013.09.026

    authors： Hiramatsu R,Matsuoka T,Kimura-Yoshida C,Han SW,Mochida K,Adachi T,Takayama S,Matsuo I

    更新日期：2013-10-28 00:00:00

  • Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression.

    abstract：:Although autophagy is being pursued as a therapeutic target in clinical oncology trials, its effects on metastasis, the principal cause of cancer mortality, remain unclear. Here, we utilize mammary cancer models to temporally delete essential autophagy regulators during carcinoma progression. Though genetic ablation o...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2020.01.025

    authors： Marsh T,Kenific CM,Suresh D,Gonzalez H,Shamir ER,Mei W,Tankka A,Leidal AM,Kalavacherla S,Woo K,Werb Z,Debnath J

    更新日期：2020-03-09 00:00:00

  • The bacterial cytoskeleton: in vivo dynamics of the actin-like protein Mbl of Bacillus subtilis.

    abstract：:Mbl is a bacterial actin homolog that controls cell morphogenesis in Bacillus subtilis. A functional GFP-Mbl fusion protein was used to examine the behavior of the helical cables formed by Mbl protein in live B. subtilis cells. The cables undergo dynamic changes during cell cycle progression. They are stable but not r...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(02)00403-3

    authors： Carballido-López R,Errington J

    更新日期：2003-01-01 00:00:00

  • Chemokine signaling mediates self-organizing tissue migration in the zebrafish lateral line.

    abstract：:The shape of most complex organ systems arises from the directed migration of cohesive groups of cells. Here, we dissect the role of the chemokine guidance receptor Cxcr4b in regulating the collective migration of one such cohesive tissue, the zebrafish lateral line primordium. Using in vivo imaging, we show that the ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2006.02.019

    authors： Haas P,Gilmour D

    更新日期：2006-05-01 00:00:00

  • Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

    abstract：:Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2008.01.005

    authors： Langer EM,Feng Y,Zhaoyuan H,Rauscher FJ 3rd,Kroll KL,Longmore GD

    更新日期：2008-03-01 00:00:00

  • The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.

    abstract：:To ensure equal chromosome segregation during mitosis, the macromolecular kinetochore must remain attached to depolymerizing microtubules, which drive chromosome movements. How kinetochores associate with depolymerizing microtubules, which undergo dramatic structural changes forming curved protofilaments, has yet to b...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2012.09.012

    authors： Schmidt JC,Arthanari H,Boeszoermenyi A,Dashkevich NM,Wilson-Kubalek EM,Monnier N,Markus M,Oberer M,Milligan RA,Bathe M,Wagner G,Grishchuk EL,Cheeseman IM

    更新日期：2012-11-13 00:00:00

  • Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium.

    abstract：:To enable stratification and barrier function, the epidermis must permit self-renewal while maintaining adhesive connections. By generating K14-GFP-actin mice to monitor actin dynamics in cultured primary keratinocytes, we uncovered a role for the actin cytoskeleton in establishing cellular organization. During epider...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(02)00259-9

    authors： Vaezi A,Bauer C,Vasioukhin V,Fuchs E

    更新日期：2002-09-01 00:00:00

  • The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

    abstract：:The serine threonine kinase Akt is a core survival factor that underlies a variety of human diseases. Although regulatory phosphorylation and dephosphorylation have been well documented, the other posttranslational mechanisms that modulate Akt activity remain unclear. We show here that tetratricopeptide repeat domain ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2009.09.007

    authors： Suizu F,Hiramuki Y,Okumura F,Matsuda M,Okumura AJ,Hirata N,Narita M,Kohno T,Yokota J,Bohgaki M,Obuse C,Hatakeyama S,Obata T,Noguchi M

    更新日期：2009-12-01 00:00:00

  • Essential role of TGF-beta signaling in glucose-induced cell hypertrophy.

    abstract：:In multicellular organisms, cell size is tightly controlled by nutrients and growth factors. Increasing ambient glucose induces enhanced protein synthesis and cell size. Continued exposure of cells to high glucose in vivo, as apparent under pathological conditions, results in cell hypertrophy and tissue damage. We dem...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2009.05.010

    authors： Wu L,Derynck R

    更新日期：2009-07-01 00:00:00

  • Exit from proliferation during leaf development in Arabidopsis thaliana: a not-so-gradual process.

    abstract：:Early leaf growth is sustained by cell proliferation and subsequent cell expansion that initiates at the leaf tip and proceeds in a basipetal direction. Using detailed kinematic and gene expression studies to map these stages during early development of the third leaf of Arabidopsis thaliana, we showed that the cell-c...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2011.11.011

    authors： Andriankaja M,Dhondt S,De Bodt S,Vanhaeren H,Coppens F,De Milde L,Mühlenbock P,Skirycz A,Gonzalez N,Beemster GT,Inzé D

    更新日期：2012-01-17 00:00:00

  • Mechanochemical Polarization of Contiguous Cell Walls Shapes Plant Pavement Cells.

    abstract：:The epidermis of aerial plant organs is thought to be limiting for growth, because it acts as a continuous load-bearing layer, resisting tension. Leaf epidermis contains jigsaw puzzle piece-shaped pavement cells whose shape has been proposed to be a result of subcellular variations in expansion rate that induce local ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2017.10.017

    authors： Majda M,Grones P,Sintorn IM,Vain T,Milani P,Krupinski P,Zagórska-Marek B,Viotti C,Jönsson H,Mellerowicz EJ,Hamant O,Robert S

    更新日期：2017-11-06 00:00:00

  • Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle.

    abstract：:Gastric acid secretion by parietal cells requires trafficking and exocytosis of H/K-ATPase-rich tubulovesicles (TVs) toward apical membranes in response to histamine stimulation via cyclic AMP elevation. Here, we found that TRPML1 (ML1), a protein that is mutated in type IV mucolipidosis (ML-IV), is a tubulovesicular ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2017.04.003

    authors： Sahoo N,Gu M,Zhang X,Raval N,Yang J,Bekier M,Calvo R,Patnaik S,Wang W,King G,Samie M,Gao Q,Sahoo S,Sundaresan S,Keeley TM,Wang Y,Marugan J,Ferrer M,Samuelson LC,Merchant JL,Xu H

    更新日期：2017-05-08 00:00:00