Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.

abstract：:Since the discovery of double fertilization, it has been recognized that flowering plants produce two highly dimorphic female gametes, the egg cell and central cell. These give rise, respectively, to the embryo and the endosperm, a nourishing tissue unique to flowering plants. Here we show that in Arabidopsis, endospe...

journal_title：Developmental cell

authors： Yuan L,Liu Z,Song X,Johnson C,Yu X,Sundaresan V

更新日期：2016-04-04 00:00:00

abstract：:The vertebral column derives from somites generated by segmentation of presomitic mesoderm (PSM). Somitogenesis involves a molecular oscillator, the segmentation clock, controlling periodic Notch signaling in the PSM. Here, we establish a novel link between Wnt/beta-catenin signaling and the segmentation clock. Axin2,...

journal_title：Developmental cell

authors： Aulehla A,Wehrle C,Brand-Saberi B,Kemler R,Gossler A,Kanzler B,Herrmann BG

更新日期：2003-03-01 00:00:00

abstract：:Airway smooth muscle is best known for its role as an airway constrictor in diseases such as asthma. However, its function in lung development is debated. A prevalent model, supported by in vitro data, posits that airway smooth muscle promotes lung branching through peristalsis and pushing intraluminal fluid to branch...

journal_title：Developmental cell

authors： Young RE,Jones MK,Hines EA,Li R,Luo Y,Shi W,Verheyden JM,Sun X

更新日期：2020-04-06 00:00:00

abstract：:Genome condensation during mitosis presents a chromatin landscape largely inaccessible to RNA polymerase II and most transcription factors. Caravaca et al. (2013) now report in Genes and Development that the pioneer transcription factor FOXA1 is retained at mitotic chromosomes, bookmarking the genome to enable gene ex...

journal_title：Developmental cell

authors： Rada-Iglesias A

更新日期：2013-02-25 00:00:00

abstract：:During embryonic development, cells must establish fates, morphologies, and behaviors in coordination with one another to form a functional body. A prevalent hypothesis for how this coordination is achieved is that each cell's fate and behavior is determined by a defined mixture of RNAs. Only recently has it become po...

journal_title：Developmental cell

authors： Tintori SC,Osborne Nishimura E,Golden P,Lieb JD,Goldstein B

更新日期：2016-08-22 00:00:00

abstract：:Mouse anterior-posterior axis polarization is preceded by formation of the distal visceral endoderm (DVE) by unknown mechanisms. Here, we show by in vitro culturing of embryos immediately after implantation in microfabricated cavities that the external mechanical cues exerted on the embryo are crucial for DVE formatio...

journal_title：Developmental cell

authors： Hiramatsu R,Matsuoka T,Kimura-Yoshida C,Han SW,Mochida K,Adachi T,Takayama S,Matsuo I

更新日期：2013-10-28 00:00:00

abstract：:Regulating cell proliferation and differentiation in CNS development requires both extraordinary complexity and precision. Neural progenitors receive graded overlapping signals from midline signaling centers, yet each makes a unique cell fate decision in a spatiotemporally restricted pattern. The Nde1-Lis1 complex reg...

journal_title：Developmental cell

authors： Lanctot AA,Peng CY,Pawlisz AS,Joksimovic M,Feng Y

更新日期：2013-05-13 00:00:00

abstract：:Branching morphogenesis is a key process in the formation of vascular networks. To date, little is known regarding the molecular events regulating this process. We investigated the involvement of synectin in this process. In zebrafish embryos, synectin knockdown resulted in a hypoplastic dorsal aorta and hypobranched,...

journal_title：Developmental cell

authors： Chittenden TW,Claes F,Lanahan AA,Autiero M,Palac RT,Tkachenko EV,Elfenbein A,Ruiz de Almodovar C,Dedkov E,Tomanek R,Li W,Westmore M,Singh JP,Horowitz A,Mulligan-Kehoe MJ,Moodie KL,Zhuang ZW,Carmeliet P,Simons M

更新日期：2006-06-01 00:00:00

abstract：:The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids once all chromosomes are attached via kinetochores by microtubules of the mitotic spindle. Reporting in Developmental Cell, Silió et al. (2015) show that in human cells the signaling cascade controlling the checkpoint ope...

journal_title：Developmental cell

authors： Meraldi P

更新日期：2015-12-07 00:00:00

abstract：:A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed commitment regulates mammalian nephrogenesis. Intersectional studies using chromatin immunoprecipitation and transcriptional profiling identified direct target genes shared by each pathway within nephron progenitors. Wnt4 and Fgf8 are e...

journal_title：Developmental cell

authors： Park JS,Ma W,O'Brien LL,Chung E,Guo JJ,Cheng JG,Valerius MT,McMahon JA,Wong WH,McMahon AP

更新日期：2012-09-11 00:00:00

abstract：:Plant steroid hormones, brassinosteroids (BRs), are perceived by a cell surface receptor kinase, BRI1, but how BR binding leads to regulation of gene expression in the nucleus is unknown. Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway. A dominant mutation bzr1-...

journal_title：Developmental cell

authors： Wang ZY,Nakano T,Gendron J,He J,Chen M,Vafeados D,Yang Y,Fujioka S,Yoshida S,Asami T,Chory J

更新日期：2002-04-01 00:00:00

abstract：:Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...

journal_title：Developmental cell

authors： Gonzales KAU,Fuchs E

更新日期：2017-11-20 00:00:00

abstract：:Dynamin family members are large GTPases that assemble into multimeric spirals. These spirals promote membrane fission or fusion, or they inhibit processes such as viral replication. Two new studies by Chappie et al. and Gao et al. in a recent issue of Nature identify interactions between subunits of dynamin spirals, ...

journal_title：Developmental cell

authors： van der Bliek AM,Payne GS

更新日期：2010-05-18 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes. Here, we show that the transmembrane protein, Nogo-A, inhibits neurite outgrowth and cell spreading in neurons and Nogo-A-responsive cell lines via HSPGs. The extracellular, active 180 amino acid Nogo-A regio...

journal_title：Developmental cell

authors： Kempf A,Boda E,Kwok JCF,Fritz R,Grande V,Kaelin AM,Ristic Z,Schmandke A,Schmandke A,Tews B,Fawcett JW,Pertz O,Buffo A,Schwab ME

更新日期：2017-10-09 00:00:00

abstract：:The Arf tumor suppressor is a key component of the p53 tumor surveillance pathway, and its expression is activated by abnormal proliferation signals. In a recent paper, Lees and coworkers investigate the regulation of Arf expression by E2Fs and demonstrate that in normal cells E2F3 is a pivotal repressor of Arf. ...

journal_title：Developmental cell

authors： Ginsberg D

更新日期：2004-06-01 00:00:00

abstract：:The identities of the ubiquitin-ligases active during myogenesis are largely unknown. Here we describe a RING-type E3 ligase complex specified by the adaptor protein, Ozz, a novel SOCS protein that is developmentally regulated and expressed exclusively in striated muscle. In mice, the absence of Ozz results in overt m...

journal_title：Developmental cell

authors： Nastasi T,Bongiovanni A,Campos Y,Mann L,Toy JN,Bostrom J,Rottier R,Hahn C,Conaway JW,Harris AJ,D'Azzo A

更新日期：2004-02-01 00:00:00

abstract：:Morphological constancy is universal in developing systems. It is unclear whether precise morphogenesis stems from faithful mechanical interpretation of gene expression patterns. We investigate the formation of the cephalic furrow, an epithelial fold that is precisely positioned with a linear morphology. Fold initiati...

journal_title：Developmental cell

authors： Eritano AS,Bromley CL,Bolea Albero A,Schütz L,Wen FL,Takeda M,Fukaya T,Sami MM,Shibata T,Lemke S,Wang YC

更新日期：2020-04-20 00:00:00

abstract：:Epithelial cells acquire mesenchymal characteristics during development, wound healing and inflammation, and in cancer and fibrosis. With increasing appreciation of different roles of epithelial-mesenchymal transition (EMT), we address the question of how to define and recognize EMT processes and discuss their propert...

journal_title：Developmental cell

authors： Derynck R,Weinberg RA

更新日期：2019-05-06 00:00:00

abstract：:Although the mechanisms underlying the spatial pattern formation of sensory maps have been extensively investigated, those triggering sensory map formation during development are largely unknown. Here we show that the birth of pups instructively and selectively regulates the initiation of barrel formation in the somat...

journal_title：Developmental cell

authors： Toda T,Homma D,Tokuoka H,Hayakawa I,Sugimoto Y,Ichinose H,Kawasaki H

更新日期：2013-10-14 00:00:00

abstract：:It is intuitive to speculate that nutrient availability may influence differentiation of mammalian cells. Nonetheless, a comprehensive complement of the molecular determinants involved in this process has not been elucidated yet. Here, we have investigated how nutrients (glucose) affect skeletal myogenesis. Glucose re...

journal_title：Developmental cell

authors： Fulco M,Cen Y,Zhao P,Hoffman EP,McBurney MW,Sauve AA,Sartorelli V

更新日期：2008-05-01 00:00:00

abstract：:Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the adipogenic fate of FAPs in injured and diseased muscle by restraining Hedgehog signaling. ...

journal_title：Developmental cell

authors： Perdiguero E,Serrano AL,Muñoz-Cánoves P

更新日期：2017-07-24 00:00:00

abstract：:Auxins are a class of phytohormones implicated in virtually every aspect of plant growth and development. Many early plant responses to auxin are apparently mediated by members of a family of Aux/IAA proteins that dimerize with and inhibit members of the auxin response factor (ARF) family of transcription factors. Aux...

journal_title：Developmental cell

authors： Rogg LE,Bartel B

更新日期：2001-11-01 00:00:00

abstract：:The role of mitochondria in Drosophila programmed cell death remains unclear, although certain gene products that regulate cell death seem to be evolutionarily conserved. We find that developmental programmed cell death stimuli in vivo and multiple apoptotic stimuli ex vivo induce dramatic mitochondrial fragmentation ...

journal_title：Developmental cell

authors： Goyal G,Fell B,Sarin A,Youle RJ,Sriram V

更新日期：2007-05-01 00:00:00

abstract：:Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast...

journal_title：Developmental cell

authors： Tissenbaum HA,Guarente L

更新日期：2002-01-01 00:00:00

abstract：:FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that comprise the mouse blastocyst. However, ERK signaling dynamics have never been directly visualized in live embryos. To address whether differential signaling is associated with particular cell fates and states, we generated a targe...

journal_title：Developmental cell

authors： Simon CS,Rahman S,Raina D,Schröter C,Hadjantonakis AK

更新日期：2020-11-09 00:00:00

abstract：:Ribosomes perform protein synthesis but are also involved in signaling processes, the full extent of which are still being uncovered. We report that phenotypes of mutating ribosomal proteins (Rps) are largely due to signaling. Using Drosophila, we discovered that a bZip-domain protein, Xrp1, becomes elevated in Rp mut...

journal_title：Developmental cell

authors： Lee CH,Kiparaki M,Blanco J,Folgado V,Ji Z,Kumar A,Rimesso G,Baker NE

更新日期：2018-08-20 00:00:00

abstract：:Oxysterol binding protein-related proteins (ORPs) are conserved lipid binding polypeptides, enriched at ER contacts sites. ORPs promote non-vesicular lipid transport and work as lipid sensors in the context of many cellular tasks, but the determinants of their distinct localization and function are not understood. Her...

journal_title：Developmental cell

authors： Encinar Del Dedo J,Idrissi FZ,Fernandez-Golbano IM,Garcia P,Rebollo E,Krzyzanowski MK,Grötsch H,Geli MI

更新日期：2017-12-04 00:00:00

abstract：:TORC1 is arguably the best-studied regulator of cellular growth in eukaryotes. However, its activity has not been assessed in vivo in developing multicellular organisms. Two studies in this issue of Developmental Cell (Kim et al., 2017; Romero-Pozuelo et al., 2017) surprisingly reveal a patchy, cell-cycle-controlled p...

journal_title：Developmental cell

authors： Stocker H

更新日期：2017-08-21 00:00:00

abstract：:Recently, there has been a surge in the number of pioneering studies combining experiments with quantitative modeling to explain both relatively simple modules of molecular machinery of the cell and to achieve system-level understanding of cellular networks. Here we discuss the utility and methods of modeling and revi...

journal_title：Developmental cell

authors： Mogilner A,Wollman R,Marshall WF

更新日期：2006-09-01 00:00:00

abstract：:The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR) complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent years. It has become increasingly evident that these regulatory circuits control some of the most fundamental aspects of metabolism, c...

journal_title：Developmental cell

authors： Bhaskar PT,Hay N

更新日期：2007-04-01 00:00:00