当前位置： SCI文献检索 > DEVELOPMENTAL CELL期刊下所有文献 > Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells.

Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells.

Abstract：

:Polarized delivery of signaling and adhesion molecules to the leading edge is required for directional migration of cells. Here, we describe a role for the PIP(2)-synthesizing enzyme, PIPKIγi2, in regulation of exocyst complex control of cell polarity and polarized integrin trafficking during migration. Loss of PIPKIγi2 impaired directional migration, formation of cell polarity, and integrin trafficking to the leading edge. Upon initiation of directional migration, PIPKIγi2 via PIP(2) generation controls the integration of the exocyst complex into an integrin-containing trafficking compartment that requires the talin-binding ability of PIPKIγi2, and talin for integrin recruitment to the leading edge. A PIP(2) requirement is further emphasized by inhibition of PIPKIγi2-regulated directional migration by an Exo70 mutant deficient in PIP(2) binding. These results reveal how phosphoinositide generation orchestrates polarized trafficking of integrin in coordination with talin that links integrins to the actin cytoskeleton, processes that are required for directional migration.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Thapa N,Sun Y,Schramp M,Choi S,Ling K,Anderson RA

doi

10.1016/j.devcel.2011.10.030

subject

Has Abstract

pub_date

2012-01-17 00:00:00

pages

116-30

issue

1

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(11)00483-7

journal_volume

22

pub_type

杂志文章

相关文献

DEVELOPMENTAL CELL文献大全
  • Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation.

    abstract：:Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation by regulating entry and progression of cells through the DNA synthesis phase. Cyclin E expression is normally restricted to proliferating cells. However, high levels of cyclin E are expressed in the adult brain. The function of ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2011.08.009

    authors： Odajima J,Wills ZP,Ndassa YM,Terunuma M,Kretschmannova K,Deeb TZ,Geng Y,Gawrzak S,Quadros IM,Newman J,Das M,Jecrois ME,Yu Q,Li N,Bienvenu F,Moss SJ,Greenberg ME,Marto JA,Sicinski P

    更新日期：2011-10-18 00:00:00

  • How the sea squirt nucleus tells mesoderm not to be endoderm.

    abstract：:Sea squirts are simple invertebrate chordates. In this issue of Developmental Cell, Takatori et al. show nuclear migration within ascidian mesendodermal cells enables polarized localization of Not mRNA, which encodes a homeobox protein that distinguishes mesoderm from endoderm fates. The link between nuclear migration...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2010.10.002

    authors： Parton RM,Davis I

    更新日期：2010-10-19 00:00:00

  • Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering.

    abstract：:Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively stud...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2017.09.018

    authors： Curran S,Strandkvist C,Bathmann J,de Gennes M,Kabla A,Salbreux G,Baum B

    更新日期：2017-11-20 00:00:00

  • Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs.

    abstract：:The Par polarity complex creates mutually exclusive cortical domains in diverse animal cells. Activity of the atypical protein kinase C (aPKC) is a key output of the Par complex as phosphorylation removes substrates from the Par domain. Here, we investigate how diverse, apparently unrelated Par substrates couple phosp...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2015.09.016

    authors： Bailey MJ,Prehoda KE

    更新日期：2015-10-26 00:00:00

  • Lipoprotein-heparan sulfate interactions in the Hh pathway.

    abstract：:The Drosophila lipoprotein particle, Lipophorin, bears lipid-linked morphogens on its surface and is required for long-range signaling activity of Wingless and Hedgehog. Heparan sulfate proteoglycans are also critical for trafficking and signaling of these morphogens. Here we show that Lipophorin interacts with the he...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2007.04.019

    authors： Eugster C,Panáková D,Mahmoud A,Eaton S

    更新日期：2007-07-01 00:00:00

  • RhoGAP: the next big thing for small mice?

    abstract：:The size of an organism is determined by the number and size of its constituent cells. The insulin/IGF-1 signaling systems have been long recognized to play a critical role in the determination of body size. Now the generation of mice deficient for a RhoGAP suggests that this small G protein might also regulate the gr...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/s1534-5807(02)00183-1

    authors： Birnbaum MJ

    更新日期：2002-05-01 00:00:00

  • Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.

    abstract：:The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression influences processes related to certain aggressive cancers, we examined the consequences of depleting breast cancer cells of SIRT1. We discovered tha...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2019.03.011

    authors： Latifkar A,Ling L,Hingorani A,Johansen E,Clement A,Zhang X,Hartman J,Fischbach C,Lin H,Cerione RA,Antonyak MA

    更新日期：2019-05-06 00:00:00

  • Dystroglycan and AMP kinase: polarity's protectors when the power goes out.

    abstract：:The AMP-stimulated protein kinase regulates epithelial polarity under conditions of energy depletion by phosphorylating the myosin regulatory light chain. In this issue of Developmental Cell, Mirouse et al. demonstrate that dystroglycan and perlecan, an extracellular matrix receptor and its ligand, help localize myosi...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2008.12.004

    authors： Zhang L,Seo-Mayer P,Caplan MJ

    更新日期：2009-01-01 00:00:00

  • Multiplexing MIM.

    abstract：:Signaling circuits often coordinate cellular membranes and actin filaments at distinct sites to direct cell behavior. In this issue of Developmental Cell, Bershteyn et al. outline how the molecular scaffold protein, MIM, which bends membranes and binds actin filaments, is at the middle of one such circuit to regulate ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2010.07.021

    authors： Kozminski KG,Schafer DA

    更新日期：2010-08-17 00:00:00

  • Variations in the efficiency of lineage marking and ablation confound distinctions between myogenic cell populations.

    abstract：:The myogenic regulatory genes Myf5, Mrf4, Myod, and Myogenin likely arose by gene duplications during evolution, presumably to address the more demanding requirements of the vertebrate body plan. Two cell lineages were proposed to be regulated independently by Myf5 and Myod to safeguard against tissue failure. Here we...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2014.11.005

    authors： Comai G,Sambasivan R,Gopalakrishnan S,Tajbakhsh S

    更新日期：2014-12-08 00:00:00

  • Tissue-Scale Mechanical Coupling Reduces Morphogenetic Noise to Ensure Precision during Epithelial Folding.

    abstract：:Morphological constancy is universal in developing systems. It is unclear whether precise morphogenesis stems from faithful mechanical interpretation of gene expression patterns. We investigate the formation of the cephalic furrow, an epithelial fold that is precisely positioned with a linear morphology. Fold initiati...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2020.02.012

    authors： Eritano AS,Bromley CL,Bolea Albero A,Schütz L,Wen FL,Takeda M,Fukaya T,Sami MM,Shibata T,Lemke S,Wang YC

    更新日期：2020-04-20 00:00:00

  • Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells.

    abstract：:Efficient regeneration following injury is critical for maintaining tissue function and enabling organismal survival. Cells reconstituting damaged tissue are often generated from resident stem or progenitor cells or from cells that have dedifferentiated and become proliferative. While lineage-tracing studies have defi...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2015.04.025

    authors： Iyengar S,Kasheta M,Ceol CJ

    更新日期：2015-06-22 00:00:00

  • Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration.

    abstract：:Zebrafish heart regeneration occurs through the activation of cardiomyocyte proliferation in areas of trauma. Here, we show that within 3 hr of ventricular injury, the entire endocardium undergoes morphological changes and induces expression of the retinoic acid (RA)-synthesizing enzyme raldh2. By one day posttrauma, ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2011.01.010

    authors： Kikuchi K,Holdway JE,Major RJ,Blum N,Dahn RD,Begemann G,Poss KD

    更新日期：2011-03-15 00:00:00

  • Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.

    abstract：:Angiogenesis is responsible for tissue vascularization during development, as well as in pathological contexts, including cancer and ischemia. Vascular endothelial growth factors (VEGFs) regulate angiogenesis by acting through VEGF receptors to induce endothelial cell signaling. VEGF is processed in the extracellular ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2016.12.017

    authors： De Angelis JE,Lagendijk AK,Chen H,Tromp A,Bower NI,Tunny KA,Brooks AJ,Bakkers J,Francois M,Yap AS,Simons C,Wicking C,Hogan BM,Smith KA

    更新日期：2017-01-23 00:00:00

  • A wapl a day keeps the sisters apart: wapl and cohesin dynamics.

    abstract：:Sister chromatids are held together by the cohesin complex from the time they are made until cell division. In recent articles published in Cell and Current Biology, the characterization of Wapl, a newly identified cohesin-interacting protein, suggests that a dynamic interaction between the cohesin complex and chromat...

    journal_title：Developmental cell

    pub_type： 社论

    doi：10.1016/j.devcel.2006.11.010

    authors： Rankin S

    更新日期：2006-12-01 00:00:00

  • Strigolactones and shoot branching: a new trick for a young dog.

    abstract：:Strigolactones secreted by plant roots are exploited by parasitic plants as germination triggers, making their synthesis and signaling important targets for crop protection. Meanwhile, genetic analyses have identified several genes required for the synthesis and signaling of an unknown shoot branching inhibitor. Two r...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2008.08.008

    authors： Leyser O

    更新日期：2008-09-01 00:00:00

  • Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains.

    abstract：:Wnt/β-catenin signaling plays critical roles during embryogenesis, tissue homeostasis, and regeneration. How Wnt-receptor complex activity is regulated is not yet fully understood. Here, we identify the Ly6 family protein LY6/PLAUR domain-containing 6 (Lypd6) as a positive feedback regulator of Wnt/β-catenin signaling...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2013.07.020

    authors： Özhan G,Sezgin E,Wehner D,Pfister AS,Kühl SJ,Kagermeier-Schenk B,Kühl M,Schwille P,Weidinger G

    更新日期：2013-08-26 00:00:00

  • Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation.

    abstract：:CLIPs are microtubule plus end-associated proteins that mediate interactions required for cell polarity and cell division. Here we demonstrate that budding yeast Bik1, unlike its human ortholog CLIP-170, is targeted to the microtubule plus end by a kinesin-dependent transport mechanism. Bik1 forms a complex with the k...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2004.05.001

    authors： Carvalho P,Gupta ML Jr,Hoyt MA,Pellman D

    更新日期：2004-06-01 00:00:00

  • Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta.

    abstract：:The Drosophila gene neuralized (neur) has long been recognized to be essential for the proper execution of a wide variety of processes mediated by the Notch (N) pathway, but its role in the pathway has been elusive. In this report, we present genetic and biochemical evidence that Neur is a RING-type, E3 ubiquitin liga...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(01)00092-2

    authors： Lai EC,Deblandre GA,Kintner C,Rubin GM

    更新日期：2001-12-01 00:00:00

  • A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size.

    abstract：:The Hippo/Yki and RB/E2F pathways both regulate tissue growth by affecting cell proliferation and survival, but interactions between these parallel control systems are poorly defined. In this study, we demonstrate that interaction between Drosophila E2F1 and Sd disrupts Yki/Sd complex formation and thereby suppresses ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2017.10.033

    authors： Zhang P,Pei C,Wang X,Xiang J,Sun BF,Cheng Y,Qi X,Marchetti M,Xu JW,Sun YP,Edgar BA,Yuan Z

    更新日期：2017-12-04 00:00:00

  • Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis.

    abstract：:The ability of the death ligand TRAIL to induce tumor cell apoptosis has led to the development of TRAIL-based cancer therapies. Reporting recently in Molecular Cell, Lu et al. (2014) show that the basis for differential TRAIL responses involves clustering of death receptor complexes by E-cadherin and the actin cytosk...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2014.06.031

    authors： Gallegos LL,Brugge JS

    更新日期：2014-07-14 00:00:00

  • Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT.

    abstract：:Little is known about the mechanisms governing neonatal growth and maturation of organs. Here we demonstrate that calcineurin/Nuclear Factor of Activated T cells (Cn/NFAT) signaling regulates neonatal pancreatic development in mouse and human islets. Inactivation of calcineurin b1 (Cnb1) in mouse islets impaired dense...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2012.05.014

    authors： Goodyer WR,Gu X,Liu Y,Bottino R,Crabtree GR,Kim SK

    更新日期：2012-07-17 00:00:00

  • Planar Differential Growth Rates Initiate Precise Fold Positions in Complex Epithelia.

    abstract：:Tissue folding is a fundamental process that shapes epithelia into complex 3D organs. The initial positioning of folds is the foundation for the emergence of correct tissue morphology. Mechanisms forming individual folds have been studied, but the precise positioning of folds in complex, multi-folded epithelia is less...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2019.09.009

    authors： Tozluoǧlu M,Duda M,Kirkland NJ,Barrientos R,Burden JJ,Muñoz JJ,Mao Y

    更新日期：2019-11-04 00:00:00

  • Targeted De Novo Centromere Formation in Drosophila Reveals Plasticity and Maintenance Potential of CENP-A Chromatin.

    abstract：:Centromeres are essential for accurate chromosome segregation and are marked by centromere protein A (CENP-A) nucleosomes. Mis-targeted CENP-A chromatin has been shown to seed centromeres at non-centromeric DNA. However, the requirements for such de novo centromere formation and transmission in vivo remain unknown. He...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2020.01.005

    authors： Palladino J,Chavan A,Sposato A,Mason TD,Mellone BG

    更新日期：2020-02-10 00:00:00

  • Melanocortin Receptor 4 Signaling Regulates Vertebrate Limb Regeneration.

    abstract：:Melanocortin 4 receptor (Mc4r) plays a crucial role in the central control of energy homeostasis, but its role in peripheral organs has not been fully explored. We have investigated the roles of hypothalamus-mediated energy metabolism during Xenopus limb regeneration. We report that hypothalamus injury inhibits Xenopu...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2018.07.021

    authors： Zhang M,Chen Y,Xu H,Yang L,Yuan F,Li L,Xu Y,Chen Y,Zhang C,Lin G

    更新日期：2018-08-20 00:00:00

  • A Hierarchical Regulatory Landscape during the Multiple Stages of EMT.

    abstract：:Epithelial-mesenchymal transition (EMT) enables cells to gain migratory and invasive features underlined by major transcriptional and epigenetic reprogramming. However, most studies have focused on the endpoints of the EMT process, and the epistatic hierarchy of the transcriptional networks underlying EMT has remained...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2018.12.023

    authors： Meyer-Schaller N,Cardner M,Diepenbruck M,Saxena M,Tiede S,Lüönd F,Ivanek R,Beerenwinkel N,Christofori G

    更新日期：2019-02-25 00:00:00

  • A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action.

    abstract：:The intricate interplay between NF-kappaB and JNK determines TNF-alpha cytotoxicity. In a recent Cell paper, report that prolonged JNK1 activation promotes TNF-alpha killing via E3 ligase-mediated degradation of the caspase 8 inhibitor cFLIP(L). On the other hand, Ventura et al. (2006) show in their recent Molecular C...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2006.02.006

    authors： Lin A

    更新日期：2006-03-01 00:00:00

  • Evolving Genital Structures: A Deep Look at Network Co-option.

    abstract：:Novel body structures are often generated by the redeployment of ancestral components of the genome. In this issue of Developmental Cell, Glassford et al. (2015) present a thorough analysis of the co-option of a gene regulatory network in the origin of an evolutionary novelty. ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2015.08.022

    authors： Preger-Ben Noon E,Frankel N

    更新日期：2015-09-14 00:00:00

  • How to Plumb a Pisces: Understanding Vascular Development and Disease Using Zebrafish Embryos.

    abstract：:Our vasculature plays diverse and critical roles in homeostasis and disease. In recent decades, the use of zebrafish has driven our understanding of vascular development into new areas, identifying new genes and mechanisms controlling vessel formation and allowing unprecedented observation of the cellular and molecula...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.devcel.2017.08.015

    authors： Hogan BM,Schulte-Merker S

    更新日期：2017-09-25 00:00:00

  • Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle.

    abstract：:Gastric acid secretion by parietal cells requires trafficking and exocytosis of H/K-ATPase-rich tubulovesicles (TVs) toward apical membranes in response to histamine stimulation via cyclic AMP elevation. Here, we found that TRPML1 (ML1), a protein that is mutated in type IV mucolipidosis (ML-IV), is a tubulovesicular ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2017.04.003

    authors： Sahoo N,Gu M,Zhang X,Raval N,Yang J,Bekier M,Calvo R,Patnaik S,Wang W,King G,Samie M,Gao Q,Sahoo S,Sundaresan S,Keeley TM,Wang Y,Marugan J,Ferrer M,Samuelson LC,Merchant JL,Xu H

    更新日期：2017-05-08 00:00:00