Abstract：
:Novel body structures are often generated by the redeployment of ancestral components of the genome. In this issue of Developmental Cell, Glassford et al. (2015) present a thorough analysis of the co-option of a gene regulatory network in the origin of an evolutionary novelty.
journal_name
Dev Celljournal_title
Developmental cellauthors
Preger-Ben Noon E,Frankel Ndoi
10.1016/j.devcel.2015.08.022subject
Has Abstractpub_date
2015-09-14 00:00:00pages
485-6issue
5eissn
1534-5807issn
1878-1551pii
S1534-5807(15)00556-0journal_volume
34pub_type
评论,杂志文章abstract：:Unravelling the role of cytoskeleton regulators may be complicated by adaptations to experimental manipulations. In this issue of Developmental Cell, Cerikan et al. (2016) reveal how acute effects of DOCK6 RhoGEF depletion on RAC1 and CDC42 activation are reversed over time by compensatory mechanisms that re-establish...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2016.09.020
更新日期：2016-10-10 00:00:00
abstract：:Hedgehog (Hh) signaling during development and in postembryonic tissues requires activation of the 7TM oncoprotein Smoothened (Smo) by mechanisms that may involve endogenous lipidic modulators. Exogenous Smo ligands previously identified include the plant sterol cyclopamine (and its therapeutically useful synthetic mi...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.07.015
更新日期：2013-08-26 00:00:00
abstract：:Reactive oxygen species (ROS), despite having damaging roles, serve as signaling molecules regulating diverse biological and physiological processes. Employing in vivo genetic studies in Drosophila, we show that besides causing G1-S arrest by activation of Dacapo, ROS can simultaneously inhibit cell growth by regulati...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.04.008
更新日期：2019-05-06 00:00:00
abstract：:Infectious, self-propagating protein aggregates (prions) as well as structurally related amyloid fibrils have traditionally been associated with neurodegenerative diseases in mammals. However, recent work in fungi indicates that prions are not simply aberrations of protein folding, but are in fact widespread, conserve...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/s1534-5807(02)00118-1
更新日期：2002-02-01 00:00:00
abstract：:Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified cells into other cell types. This is especially critical during embryogenesis, when extensive cell proliferation, patterning, and migration events take place. Here we show that vertebrate primordial germ cells (PGCs) are pr...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.11.019
更新日期：2017-12-18 00:00:00
abstract：:The Cubitus interruptus (Ci)/Gli family of transcription factors can be degraded either completely or partially from a full-length form (Ci155/Gli(FL)) to a truncated repressor (Ci75/Gli(R)) by proteasomes to mediate Hedgehog (Hh) signaling. The mechanism by which proteasomes distinguish ubiquitinated Ci/Gli to carry ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.05.006
更新日期：2013-06-24 00:00:00
abstract：:Little is known about the mechanisms governing neonatal growth and maturation of organs. Here we demonstrate that calcineurin/Nuclear Factor of Activated T cells (Cn/NFAT) signaling regulates neonatal pancreatic development in mouse and human islets. Inactivation of calcineurin b1 (Cnb1) in mouse islets impaired dense...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.05.014
更新日期：2012-07-17 00:00:00
abstract：:Many different intercellular signaling pathways are known but, for most, it is unclear whether they can generate oscillating cell behaviors. Here we use time-lapse analysis of Drosophila embryogenesis to show that oenocytes delaminate from the ectoderm in discrete bursts of three. This pulsatile process has a 1 hour p...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.10.016
更新日期：2004-12-01 00:00:00
abstract：:BMP signaling is essential for promoting self-renewal of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell proliferation in the mouse intestine and skin. However, it remains unknown whether BMP signaling can promote self-renewal of adult somatic stem cells. In this study, we sh...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.09.013
更新日期：2005-11-01 00:00:00
abstract：:Exponential increase of cell numbers in early embryos requires large amounts of DNA precursors (deoxyribonucleoside triphosphates (dNTPs)). Little is understood about how embryos satisfy this demand. We examined dNTP metabolism in the early Drosophila embryo, in which gastrulation is preceded by 13 sequential nuclear ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.06.013
更新日期：2017-08-07 00:00:00
abstract：:Fission yeast Pat1 kinase inhibits sexual differentiation by phosphorylating the meiotic inducer Mei2 and the transcription factor Ste11. Here, we show how Pat1 downregulates these proteins. Mei2 is degraded via a ubiquitin-proteasome pathway in a phosphorylation-dependent fashion. The E2 Ubc2 and the E3 Ubr1 are requ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(01)00037-5
更新日期：2001-09-01 00:00:00
abstract：:The cilia and cell cycles are inextricably linked. Centrioles in the basal body of cilia nucleate the ciliary axoneme and sequester pericentriolar matrix (PCM) at the centrosome to organize the mitotic spindle. Cilia themselves respond to growth signals, prompting cilia resorption and cell cycle re-entry. We describe ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.10.027
更新日期：2018-11-19 00:00:00
abstract：:The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney deve...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.04.012
更新日期：2015-05-04 00:00:00
abstract：:TGF-beta superfamily signaling pathways emerged with the evolution of multicellular animals, suggesting that these pathways contribute to the increased diversity and complexity required for the development and homeostasis of these organisms. In this review we begin by exploring some key developmental and disease proce...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2009.02.012
更新日期：2009-03-01 00:00:00
abstract：:SAG/RBX2/ROC2 protein is an essential RING component of SCF E3 ubiquitin ligase. The role of SAG during embryogenesis remains unknown. We report a critical role for SAG in controlling vascular and neural development by modulating RAS activity via promoting degradation of neurofibromatosis type 1 (NF1). Mice mutant for...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.09.014
更新日期：2011-12-13 00:00:00
abstract：:The frizzled (fz) gene of Drosophila is required for planar polarity establishment in the adult cuticle, acting both cell autonomously and nonautonomously. We demonstrate that these two activities of fz in planar polarity are temporally separable in both the eye and wing. The nonautonomous function is dishevelled (dsh...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00363-5
更新日期：2002-12-01 00:00:00
abstract：:Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.01.005
更新日期：2008-03-01 00:00:00
abstract：:In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2019.05.030
更新日期：2019-06-03 00:00:00
abstract：:In multicellular organisms, cell size is tightly controlled by nutrients and growth factors. Increasing ambient glucose induces enhanced protein synthesis and cell size. Continued exposure of cells to high glucose in vivo, as apparent under pathological conditions, results in cell hypertrophy and tissue damage. We dem...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.05.010
更新日期：2009-07-01 00:00:00
abstract：:Directional cell migration is critical for metazoan development. We define two molecular pathways that activate the Arp2/3 complex during neuroblast migration in Caenorhabditis elegans. The transmembrane protein MIG-13/Lrp12 is linked to the Arp2/3 nucleation-promoting factors WAVE or WASP through direct interactions ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.09.029
更新日期：2016-10-24 00:00:00
abstract：:RNA-binding Fox (Rbfox) proteins have well-established roles in regulating alternative splicing, but specific Rbfox isoforms lack nuclear localization signals and accumulate in the cytoplasm. The potential splicing-independent functions of these proteins remain unknown. Here we demonstrate that cytoplasmic Drosophila ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.02.010
更新日期：2016-03-07 00:00:00
abstract：:Messenger RNAs (mRNAs) are synthesized in the cell nucleus and transported through nuclear pores to the cytoplasm for protein synthesis. Reporting in Nature Cell Biology, Mor et al. now track in living cells in real time the journey of single mRNA molecules as they transit from nucleus to cytoplasm. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2010.05.021
更新日期：2010-06-15 00:00:00
abstract：:Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively stud...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.09.018
更新日期：2017-11-20 00:00:00
abstract：:In a recent issue of Cell, Coureuil et al. (2010) show that type IV pili of Neisseria meningitidis-the causative bacterium of cerebrospinal meningitis-bind to the endothelial β2-adrenoceptor and elicit biased β-arrestin signaling resulting in microvilli formation and paracytotic bacterial migration. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2010.12.011
更新日期：2011-01-18 00:00:00
abstract：:The advent of reprogramming and its impact on stem cell biology has renewed interest in lineage restriction in mammalian embryos, the source of embryonic (ES), epiblast (EpiSC), trophoblast (TS), and extraembryonic endoderm (XEN) stem cell lineages. Isolation of specific cell types during stem cell differentiation and...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.01.005
更新日期：2012-04-17 00:00:00
abstract：:Neutrophils, in response to a chemoattractant gradient, undergo dynamic F-actin remodeling, a process important for their directional migration or chemotaxis. However, signaling mechanisms for chemoattractants to regulate the process are incompletely understood. Here, we characterized chemoattractant-activated signali...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.10.023
更新日期：2011-12-13 00:00:00
abstract：:Embryonic organizers establish gradients of diffusible signaling molecules to pattern the surrounding cells. Here, we elucidate an additional mechanism of embryonic organizers that is a secondary consequence of morphogen signaling. Using pharmacological and localized transgenic perturbations, 4D imaging of the zebrafi...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.05.014
更新日期：2019-06-17 00:00:00
abstract：:Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.01.020
更新日期：2008-04-01 00:00:00
abstract：:Inherited mtDNA mutations cause severe human disease. In most species, mitochondria are inherited maternally through mechanisms that are poorly understood. Genes that specifically control the inheritance of mitochondria in the germline are unknown. Here, we show that the long isoform of the protein Oskar regulates the...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.11.004
更新日期：2016-12-05 00:00:00
abstract：:The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the renal collecting system. Although development of a normal kidney depends on proper ureteric bud morphogenesis, the cellular events underlying this process remain obscure. Here, we used time-lapse microscopy together with several ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.09.001
更新日期：2013-11-11 00:00:00
