Abstract：
:What coordinates the internal leading and trailing edges in collectively migrating cells is largely unknown. In this issue of Developmental Cell, Barlan et al. (2017) delineate a Fat2/Lar planar signaling pathway at the basal, motile cell-cell contacts of Drosophila egg chamber follicle cells.
journal_name
Dev Celljournal_title
Developmental cellauthors
Mao Q,Lavalou J,Lecuit Tdoi
10.1016/j.devcel.2017.02.025subject
Has Abstractpub_date
2017-03-13 00:00:00pages
425-426issue
5eissn
1534-5807issn
1878-1551pii
S1534-5807(17)30121-1journal_volume
40pub_type
评论,杂志文章abstract：:What are the thermodynamic costs of development? In this issue of Developmental Cell, Rodenfels et al. (2019) demonstrate that the high energetic cost of coordinated cell division that is regulated by phospho-signaling gives rise to a measurable periodicity in the heat dissipated during zebrafish embryogenesis. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2019.02.016
更新日期：2019-03-11 00:00:00
abstract：:Secreted proteins of the Wnt family affect axon guidance, asymmetric cell division, and cell fate. We show here that C. elegans Wnts acting through Frizzled receptors can shape axon and dendrite trajectories by reversing the anterior-posterior polarity of neurons. In lin-44/Wnt and lin-17/Frizzled mutants, the polarit...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.01.013
更新日期：2006-03-01 00:00:00
abstract：:Gastric acid secretion by parietal cells requires trafficking and exocytosis of H/K-ATPase-rich tubulovesicles (TVs) toward apical membranes in response to histamine stimulation via cyclic AMP elevation. Here, we found that TRPML1 (ML1), a protein that is mutated in type IV mucolipidosis (ML-IV), is a tubulovesicular ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.04.003
更新日期：2017-05-08 00:00:00
abstract：:The spinal cord and mesodermal tissues of the trunk such as the vertebral column and skeletal musculature derive from neuro-mesodermal progenitors (NMPs). Sox2, Brachyury (T), and Tbx6 have been correlated with NMP potency and lineage choice; however, their exact role and interaction in these processes have not yet be...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.07.021
更新日期：2017-09-11 00:00:00
abstract：:The early midgut undergoes intensive elongation, but the underlying cellular and molecular mechanisms are unknown. The early midgut epithelium is pseudostratified, and its nuclei travel between apical and basal surfaces in concert with cell cycle. Using 3D confocal imaging and 2D live imaging, we profiled behaviors of...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.06.011
更新日期：2018-07-16 00:00:00
abstract：:Strigolactones secreted by plant roots are exploited by parasitic plants as germination triggers, making their synthesis and signaling important targets for crop protection. Meanwhile, genetic analyses have identified several genes required for the synthesis and signaling of an unknown shoot branching inhibitor. Two r...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.08.008
更新日期：2008-09-01 00:00:00
abstract：:During organogenesis, coherent organ growth arises from spatiotemporally coordinated decisions of individual cells. In the root of Arabidopsis thaliana, this coordination results in the establishment of a division and a differentiation zone. Cells continuously move through these zones; thus, a major question is how th...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.04.004
更新日期：2020-05-18 00:00:00
abstract：:The Cubitus interruptus (Ci)/Gli family of transcription factors can be degraded either completely or partially from a full-length form (Ci155/Gli(FL)) to a truncated repressor (Ci75/Gli(R)) by proteasomes to mediate Hedgehog (Hh) signaling. The mechanism by which proteasomes distinguish ubiquitinated Ci/Gli to carry ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.05.006
更新日期：2013-06-24 00:00:00
abstract：:Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through Piwi-associated RNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains unclear whether it plays any roles in early GSC...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.03.023
更新日期：2017-04-24 00:00:00
abstract：:Pancreatic beta cell proliferation is high at birth and then rapidly declines. In this issue of Developmental Cell,Stolovich-Rain et al. (2015) show that β cells' capacity to increase proliferation in response to injury is unexpectedly not acquired until after weaning-related nutritional changes trigger a metabolic an...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.02.016
更新日期：2015-03-09 00:00:00
abstract：:Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players. ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00298-3
更新日期：2003-10-01 00:00:00
abstract：:The myogenic regulatory genes Myf5, Mrf4, Myod, and Myogenin likely arose by gene duplications during evolution, presumably to address the more demanding requirements of the vertebrate body plan. Two cell lineages were proposed to be regulated independently by Myf5 and Myod to safeguard against tissue failure. Here we...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.11.005
更新日期：2014-12-08 00:00:00
abstract：:Embryonic development of the liver has been studied intensely, yielding insights that impact diverse areas of developmental and cell biology. Understanding the fundamental mechanisms that control hepatogenesis has also laid the basis for the rational differentiation of stem cells into cells that display many hepatic f...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2010.01.011
更新日期：2010-02-16 00:00:00
abstract：:Specialized areas in the vertebrate retina are critical for high-acuity vision, yet the molecular mechanisms driving the development of high-acuity areas (HAAs) remain largely unknown. In Developmental Cell, da Silva and Cepko (2017) show that restricted degradation of retinoic acid and elevated FGF8 signaling give ri...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2017.06.015
更新日期：2017-07-10 00:00:00
abstract：:MicroRNAs are important regulators of normal and malignant hematopoiesis. A paper by Lu et al. in this issue of Developmental Cell demonstrates how one microRNA, miR-150, plays a critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the widely expressed transcription factor M...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2008.05.011
更新日期：2008-06-01 00:00:00
abstract：:Reporting in Cell, Berg et al. (2016) reveal a connection between genetic lysosomal storage disorders and the ability of macrophages to migrate and control mycobacterial infection. This insight, resulting from a zebrafish genetic screen, inspired the authors to propose an explanation for the increased susceptibility o...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2016.04.004
更新日期：2016-04-18 00:00:00
abstract：:Cell locomotion entails functional and structural cooperation between cell surface adhesion and the actin cytoskeleton. A new paper by DeMali et al. provides new insights into the link between actin assembly and integrin adhesion at the leading edges of migrating cells. ...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/s1534-5807(02)00374-x
更新日期：2002-12-01 00:00:00
abstract：:Early leaf growth is sustained by cell proliferation and subsequent cell expansion that initiates at the leaf tip and proceeds in a basipetal direction. Using detailed kinematic and gene expression studies to map these stages during early development of the third leaf of Arabidopsis thaliana, we showed that the cell-c...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.11.011
更新日期：2012-01-17 00:00:00
abstract：:Yeast cells track gradients of pheromones to locate mating partners. Intuition suggests that uniform distribution of pheromone receptors over the cell surface would yield optimal gradient sensing. However, yeast cells display polarized receptors. The benefit of such polarization was unknown. During gradient tracking, ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.10.024
更新日期：2015-11-23 00:00:00
abstract：:Macropinocytosis coordinates non-specific uptake of macromolecules and fluid. Cancers employ macropinocytosis to obtain nutrients to support their metabolic homeostasis. In this issue of Developmental Cell, Lee et al. (2019) report that glutamine deprivation boosts macropinocytosis via EGFR signaling induction, provid...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2019.07.020
更新日期：2019-08-05 00:00:00
abstract：:Myelin is essential in vertebrates for the rapid propagation of action potentials, but the molecular mechanisms driving its formation remain largely unknown. Here we show that the initial stage of process extension and axon ensheathment by oligodendrocytes requires dynamic actin filament assembly by the Arp2/3 complex...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.06.011
更新日期：2015-07-27 00:00:00
abstract：:Orientation of cell division is a vital aspect of tissue morphogenesis and growth. Asymmetric divisions generate cell fate diversity and epithelial stratification, whereas symmetric divisions contribute to tissue growth, spreading, and elongation. Here, we describe a mechanism for positioning the spindle in symmetric ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.01.002
更新日期：2012-04-17 00:00:00
abstract：:Multinucleate cells are widespread in nature, yet the mechanism by which cells fuse their plasma membranes is poorly understood. To identify animal fusogens, we performed new screens for mutations that abolish cell fusion within tissues of C. elegans throughout development. We identified the gene eff-1, which is expre...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00129-6
更新日期：2002-03-01 00:00:00
abstract：:The actin remodeling factor N-WASP is best known as an Arp2/3 complex activator in processes like endocytosis, extracellular matrix degradation, and host-pathogen interaction. In this issue of Developmental Cell, Juin et al. establish a novel trafficking function for N-WASP in driving lysophosphatidic acid-dependent c...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2019.10.029
更新日期：2019-11-18 00:00:00
abstract：:DNA methylation on N6-adenine (6mA) has recently been found to be a potentially epigenetic mark in several unicellular and multicellular eukaryotes. However, its distribution patterns and potential functions in land plants, which are primary producers for most ecosystems, remain largely unknown. Here we report global ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.03.012
更新日期：2018-05-07 00:00:00
abstract：:As they enter mitosis, animal cells undergo profound actin-dependent changes in shape to become round. Here we identify the Cdk1 substrate, Ect2, as a central regulator of mitotic rounding, thus uncovering a link between the cell-cycle machinery that drives mitotic entry and its accompanying actin remodeling. Ect2 is ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.06.003
更新日期：2012-08-14 00:00:00
abstract：:The Drosophila lipoprotein particle, Lipophorin, bears lipid-linked morphogens on its surface and is required for long-range signaling activity of Wingless and Hedgehog. Heparan sulfate proteoglycans are also critical for trafficking and signaling of these morphogens. Here we show that Lipophorin interacts with the he...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.04.019
更新日期：2007-07-01 00:00:00
abstract：:We studied the role of the target of rapamycin complex 2 (mTORC2) during neutrophil chemotaxis, a process that is mediated through the polarization of actin and myosin filament networks. We show that inhibition of mTORC2 activity, achieved via knock down (KD) of Rictor, severely inhibits neutrophil polarization and di...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.11.004
更新日期：2010-12-14 00:00:00
abstract：:Human centromeres are defined by alpha satellite DNA arrays that are distinct and chromosome specific. Most human chromosomes contain multiple alpha satellite arrays that are competent for centromere assembly. Here, we show that human centromeres are defined by chromosome-specific RNAs linked to underlying organizatio...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.07.001
更新日期：2017-08-07 00:00:00
abstract：:While GDNF signaling through the Ret receptor is critical for kidney development, its specific role in branching morphogenesis of the epithelial ureteric bud (UB) is unclear. Ret expression defines a population of UB "tip cells" distinct from cells of the tubular "trunks," but how these cells contribute to UB growth i...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.11.008
更新日期：2005-01-01 00:00:00
