Abstract:
:The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane. Furthermore, Rab11 and Armadillo interact with the exocyst components Sec15 and Sec10, respectively. Our results support a model whereby the exocyst regulates DE-Cadherin trafficking, from recycling endosomes to sites on the epithelial cell membrane where Armadillo is located.
journal_name
Dev Celljournal_title
Developmental cellauthors
Langevin J,Morgan MJ,Sibarita JB,Aresta S,Murthy M,Schwarz T,Camonis J,Bellaïche Ydoi
10.1016/j.devcel.2005.07.013keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
365-76issue
3eissn
1534-5807issn
1878-1551pii
S1534-5807(05)00293-5journal_volume
9pub_type
杂志文章abstract::The developmental mechanisms that orchestrate differentiation of specific nephron segments are incompletely understood, and the factors that maintain their terminal differentiation after nephrogenesis remain largely unknown. Here, the transcription factor AP-2β is shown to be required for the differentiation of distal...
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