Abstract:
:Intercellular communication is vital to tumor progression. In this issue of Developmental Cell, Bertolini et al. (2020) describe how small extracellular vesicles released from hypoxic mammary tumor cells facilitate intercellular communication, leading to alterations in mitochondrial dynamics and acquisition of invasive phenotypes in normal epithelial cells.
journal_name
Dev Celljournal_title
Developmental cellauthors
Boomgarden AC,Clancy JW,D'Souza-Schorey Cdoi
10.1016/j.devcel.2020.09.027subject
Has Abstractpub_date
2020-10-26 00:00:00pages
111-113issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(20)30759-0journal_volume
55pub_type
杂志文章abstract::The role of mitochondria in Drosophila programmed cell death remains unclear, although certain gene products that regulate cell death seem to be evolutionarily conserved. We find that developmental programmed cell death stimuli in vivo and multiple apoptotic stimuli ex vivo induce dramatic mitochondrial fragmentation ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2007.02.002
更新日期:2007-05-01 00:00:00
abstract::The early midgut undergoes intensive elongation, but the underlying cellular and molecular mechanisms are unknown. The early midgut epithelium is pseudostratified, and its nuclei travel between apical and basal surfaces in concert with cell cycle. Using 3D confocal imaging and 2D live imaging, we profiled behaviors of...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.06.011
更新日期:2018-07-16 00:00:00
abstract::One G protein-coupled receptor (GPCR) can activate more than one G protein, but the physiologic importance of such activation has not been demonstrated in vivo. We have generated mice expressing exclusively a mutant form of the PTH/PTHrP receptor (DSEL) that activates adenylyl cyclase normally but not phospholipase C ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00218-6
更新日期:2002-08-01 00:00:00
abstract::Alzheimer's disease remains a formidable challenge for therapeutic management. In a recent report in Nature Structural and Molecular Biology, Cohen et al. (2015) present intriguing results showing that "designer" molecular chaperones may hold the key to an evolutionarily conserved program for management of toxic oligo...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.03.009
更新日期:2015-03-23 00:00:00
abstract::The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression influences processes related to certain aggressive cancers, we examined the consequences of depleting breast cancer cells of SIRT1. We discovered tha...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.03.011
更新日期:2019-05-06 00:00:00
abstract::Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2017.10.001
更新日期:2017-11-20 00:00:00
abstract::Recent studies have demonstrated that MyoD initiates a feed-forward regulation of skeletal muscle gene expression, predicting that MyoD binds directly to many genes expressed during differentiation. We have used chromatin immunoprecipitation and high-throughput sequencing to identify genome-wide binding of MyoD in sev...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.02.014
更新日期:2010-04-20 00:00:00
abstract::Despite their external bilateral symmetry, vertebrates have internal left/right (L/R) asymmetries required for optimal organ function. BMP-induced epithelial to mesenchymal transition (EMT) in the lateral plate mesoderm (LPM) triggers L/R asymmetric cell movements toward the midline, higher from the right, which are c...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.09.012
更新日期:2019-11-18 00:00:00
abstract::NAD(H)-binding proteins play important roles in cell-cycle and developmental signaling in eukaryotes. We identified a bifunctional NAD(H)-binding regulator (KidO) that integrates cell-fate signaling with cytokinesis in the bacterium Caulobacter crescentus. KidO stimulates the DivJ kinase and directly acts on the cytok...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2009.10.024
更新日期:2010-01-19 00:00:00
abstract::Spindle positioning is an essential feature of asymmetric cell division. The conserved PAR proteins together with heterotrimeric G proteins control spindle positioning in animal cells, but how these are linked is not known. In C. elegans, PAR protein activity leads to asymmetric spindle placement through cortical asym...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.06.002
更新日期:2008-08-01 00:00:00
abstract::PTEN is one of the most commonly lost tumor suppressors in human cancer and is known to inhibit insulin signaling. Eph receptor tyrosine kinases (RTKs) have also been implicated in cancer formation and progression, and they have diverse functions, including nervous and vascular system development. We show that in C. e...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2009.08.009
更新日期:2009-10-01 00:00:00
abstract::Exponential increase of cell numbers in early embryos requires large amounts of DNA precursors (deoxyribonucleoside triphosphates (dNTPs)). Little is understood about how embryos satisfy this demand. We examined dNTP metabolism in the early Drosophila embryo, in which gastrulation is preceded by 13 sequential nuclear ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2017.06.013
更新日期:2017-08-07 00:00:00
abstract::Cell-to-cell communication coordinates the behavior of individual cells to establish organ patterning and development. Although mobile signals are known to be important in lateral root development, the role of plasmodesmata (PD)-mediated transport in this process has not been investigated. Here, we show that changes i...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.06.010
更新日期:2013-07-29 00:00:00
abstract::The musculoskeletal system of vertebrates is derived from the embryonic mesoderm. Its structures are categorized as epaxial or hypaxial based on their adult position and innervation. The epaxial/hypaxial terminology is also used to describe regions of the embryonic somites based on fate mapping of somitic derivatives....
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/s1534-5807(03)00033-9
更新日期:2003-02-01 00:00:00
abstract::The regulated release of polypeptides has a central role in physiology, behavior, and development, but the mechanisms responsible for production of the large dense core vesicles (LDCVs) capable of regulated release have remained poorly understood. Recent work has implicated cytosolic adaptor protein AP-3 in the recrui...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.10.007
更新日期:2013-11-25 00:00:00
abstract::In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2019.05.030
更新日期:2019-06-03 00:00:00
abstract::Fission yeast Pat1 kinase inhibits sexual differentiation by phosphorylating the meiotic inducer Mei2 and the transcription factor Ste11. Here, we show how Pat1 downregulates these proteins. Mei2 is degraded via a ubiquitin-proteasome pathway in a phosphorylation-dependent fashion. The E2 Ubc2 and the E3 Ubr1 are requ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(01)00037-5
更新日期:2001-09-01 00:00:00
abstract::Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However, spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging. Here, we developed an optimized protocol for single-molecule transcript imaging in the intact pancreas and used it to identify a sub-po...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.11.001
更新日期:2019-01-07 00:00:00
abstract::Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/s1534-5807(01)00098-3
更新日期:2002-01-01 00:00:00
abstract::Recent data indicate that cystic fibrosis (CF) airway mucus is anaerobic. This suggests that Pseudomonas aeruginosa infection in CF reflects biofilm formation and persistence in an anaerobic environment. P. aeruginosa formed robust anaerobic biofilms, the viability of which requires rhl quorum sensing and nitric oxide...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00295-2
更新日期:2002-10-01 00:00:00
abstract::Major histocompatibility complex class Ib molecules may play a surprising role in pheromone detection in mammals. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章,评审
doi:10.1016/s1534-5807(03)00066-2
更新日期:2003-03-01 00:00:00
abstract::Myelin is essential in vertebrates for the rapid propagation of action potentials, but the molecular mechanisms driving its formation remain largely unknown. Here we show that the initial stage of process extension and axon ensheathment by oligodendrocytes requires dynamic actin filament assembly by the Arp2/3 complex...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.06.011
更新日期:2015-07-27 00:00:00
abstract::Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.01.020
更新日期:2008-04-01 00:00:00
abstract::The Drosophila compound eye consists of approximately 750 independently functioning ommatidia, each containing two photoreceptor subpopulations. The outer photoreceptors participate in motion detection, while the inner photoreceptors contribute to color vision. Although the inner photoreceptors, R7 and R8, terminally ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00156-4
更新日期:2003-06-01 00:00:00
abstract::Branching morphogenesis is a key process in the formation of vascular networks. To date, little is known regarding the molecular events regulating this process. We investigated the involvement of synectin in this process. In zebrafish embryos, synectin knockdown resulted in a hypoplastic dorsal aorta and hypobranched,...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.03.012
更新日期:2006-06-01 00:00:00
abstract::The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.07.013
更新日期:2005-09-01 00:00:00
abstract::Transmission of the human parasite Brugia malayi relies on the sustained production of larvae in blood. In this issue of Developmental Cell,Foray et al. (2018) use methods developed in the model nematode C. elegans to reveal how a symbiotic bacterium supports the female germ cell development underlying this massive fe...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2018.04.006
更新日期:2018-04-23 00:00:00
abstract::Hedgehog (Hh) signaling during development and in postembryonic tissues requires activation of the 7TM oncoprotein Smoothened (Smo) by mechanisms that may involve endogenous lipidic modulators. Exogenous Smo ligands previously identified include the plant sterol cyclopamine (and its therapeutically useful synthetic mi...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.07.015
更新日期:2013-08-26 00:00:00
abstract::Mammalian neurulation is completed when the dorsolateral neural folds bend inwards, their tips make adhesive contacts across the midline, and the epithelia remodel to create a closed neural tube. Two recent papers (one by Camerer et al. in this issue of Developmental Cell) demonstrate a vital role for protease-activat...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2010.01.002
更新日期:2010-01-19 00:00:00
abstract::Here, we show that the liver-derived apolipoprotein M (ApoM) protects the lung and kidney from pro-fibrotic insults and that this circulating factor is attenuated in aged mice. Aged mouse hepatocytes exhibit transcriptional suppression of ApoM. This leads to reduced sphingosine-1-phosphate (S1P) signaling via the S1P ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.05.024
更新日期:2020-06-22 00:00:00