Picket and other fences in biological membranes.

Abstract:

:Nakada et al. revisit the controversial question of whether membrane lipids are able to diffuse from the axon of a neuron into the soma. Using single molecule imaging of a fluorescent phospholipid, the authors show that a diffusion barrier in the axon initial segment blocks the diffusion of lipids.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Boiko T,Winckler B

doi

10.1016/s1534-5807(03)00240-5

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

191-2

issue

2

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(03)00240-5

journal_volume

5

pub_type

评论,杂志文章
  • RhoGAP: the next big thing for small mice?

    abstract::The size of an organism is determined by the number and size of its constituent cells. The insulin/IGF-1 signaling systems have been long recognized to play a critical role in the determination of body size. Now the generation of mice deficient for a RhoGAP suggests that this small G protein might also regulate the gr...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/s1534-5807(02)00183-1

    authors: Birnbaum MJ

    更新日期:2002-05-01 00:00:00

  • The CKI1 Histidine Kinase Specifies the Female Gametic Precursor of the Endosperm.

    abstract::Since the discovery of double fertilization, it has been recognized that flowering plants produce two highly dimorphic female gametes, the egg cell and central cell. These give rise, respectively, to the embryo and the endosperm, a nourishing tissue unique to flowering plants. Here we show that in Arabidopsis, endospe...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.03.009

    authors: Yuan L,Liu Z,Song X,Johnson C,Yu X,Sundaresan V

    更新日期:2016-04-04 00:00:00

  • Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche.

    abstract::Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2017.10.001

    authors: Gonzales KAU,Fuchs E

    更新日期:2017-11-20 00:00:00

  • Aberrant epigenetic landscape in cancer: how cellular identity goes awry.

    abstract::Appropriate patterns of DNA methylation and histone modifications are required to assure cell identity, and their deregulation can contribute to human diseases, such as cancer. Our aim here is to provide an overview of how epigenetic factors, including genomic DNA methylation, histone modifications, and microRNA regul...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2010.10.005

    authors: Berdasco M,Esteller M

    更新日期:2010-11-16 00:00:00

  • Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression.

    abstract::Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of widespread expression of MAP3K4, the cellular basis of this misregulation was unclear. Here, we show that mice lacking Gadd45γ also exhibit XY gonadal sex reversal ca...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2012.09.016

    authors: Warr N,Carre GA,Siggers P,Faleato JV,Brixey R,Pope M,Bogani D,Childers M,Wells S,Scudamore CL,Tedesco M,del Barco Barrantes I,Nebreda AR,Trainor PA,Greenfield A

    更新日期:2012-11-13 00:00:00

  • An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development.

    abstract::Lysosomes degrade macromolecular cargos, recycle catabolites, and serve as signaling platforms to maintain cell homeostasis, but their role at the tissue level is unclear. Here, we investigate lysosome regulation and function during C. elegans molting, a specialized extracellular matrix (ECM) remodeling process essent...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.10.020

    authors: Miao R,Li M,Zhang Q,Yang C,Wang X

    更新日期:2020-01-06 00:00:00

  • SLIT/ROBO1 signaling suppresses mammary branching morphogenesis by limiting basal cell number.

    abstract::In the field of breast biology, there is a growing appreciation for the "gatekeeping function" of basal cells during development and disease processes yet mechanisms regulating the generation of these cells are poorly understood. Here, we report that the proliferation of basal cells is controlled by SLIT/ROBO1 signali...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.05.012

    authors: Macias H,Moran A,Samara Y,Moreno M,Compton JE,Harburg G,Strickland P,Hinck L

    更新日期:2011-06-14 00:00:00

  • Defining a PARticular pathway of neural tube closure.

    abstract::Mammalian neurulation is completed when the dorsolateral neural folds bend inwards, their tips make adhesive contacts across the midline, and the epithelia remodel to create a closed neural tube. Two recent papers (one by Camerer et al. in this issue of Developmental Cell) demonstrate a vital role for protease-activat...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2010.01.002

    authors: Copp AJ,Greene ND

    更新日期:2010-01-19 00:00:00

  • The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

    abstract::The serine threonine kinase Akt is a core survival factor that underlies a variety of human diseases. Although regulatory phosphorylation and dephosphorylation have been well documented, the other posttranslational mechanisms that modulate Akt activity remain unclear. We show here that tetratricopeptide repeat domain ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2009.09.007

    authors: Suizu F,Hiramuki Y,Okumura F,Matsuda M,Okumura AJ,Hirata N,Narita M,Kohno T,Yokota J,Bohgaki M,Obuse C,Hatakeyama S,Obata T,Noguchi M

    更新日期:2009-12-01 00:00:00

  • SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth.

    abstract::The nervous system is enormously complex, yet the number of cues that control axonal growth is surprisingly meager. Posttranslational modifications amplify diversity, but the degree to which they are employed is unclear. Here, we show that Furin and SKI-1 combine with autocatalytic cleavage and a disulfide bridge to g...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.11.022

    authors: Tassew NG,Charish J,Seidah NG,Monnier PP

    更新日期:2012-02-14 00:00:00

  • 3' UTRs in the Eye of the TIGER.

    abstract::Many human genes generate mRNAs with alternative 3' untranslated regions (3' UTRs), which can modulate protein function. In a recent Cell paper, Ma and Mayr (2018) unveil a major membraneless organelle, termed the TIS granule-endoplasmic reticulum (TIGER), which enables specific 3' UTRs to encipher protein localizatio...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2018.11.022

    authors: Portz B,Shorter J

    更新日期:2018-12-03 00:00:00

  • MOR23 promotes muscle regeneration and regulates cell adhesion and migration.

    abstract::Odorant receptors (ORs) in the olfactory epithelium bind to volatile small molecules leading to the perception of smell. ORs are expressed in many tissues but their functions are largely unknown. We show multiple ORs display distinct mRNA expression patterns during myogenesis in vitro and muscle regeneration in vivo. ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2009.09.004

    authors: Griffin CA,Kafadar KA,Pavlath GK

    更新日期:2009-11-01 00:00:00

  • Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology.

    abstract::The generation and shedding of extracellular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of intercellular communication with important roles in several physiological processes and diseases such as cancer. These membrane-enclosed packets can transfer specific proteins, RNA...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2016.04.019

    authors: Desrochers LM,Antonyak MA,Cerione RA

    更新日期:2016-05-23 00:00:00

  • Coupling prokaryotic cell fate and division control with a bifunctional and oscillating oxidoreductase homolog.

    abstract::NAD(H)-binding proteins play important roles in cell-cycle and developmental signaling in eukaryotes. We identified a bifunctional NAD(H)-binding regulator (KidO) that integrates cell-fate signaling with cytokinesis in the bacterium Caulobacter crescentus. KidO stimulates the DivJ kinase and directly acts on the cytok...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2009.10.024

    authors: Radhakrishnan SK,Pritchard S,Viollier PH

    更新日期:2010-01-19 00:00:00

  • Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition.

    abstract::Renewing tissues have the remarkable ability to continually produce both proliferative progenitor and specialized differentiated cell types. How are complex milieus of microenvironmental signals interpreted to coordinate tissue-cell-type composition? Here, we investigate the responses of intestinal epithelium to indiv...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2020.12.020

    authors: Sanman LE,Chen IW,Bieber JM,Steri V,Trentesaux C,Hann B,Klein OD,Wu LF,Altschuler SJ

    更新日期:2021-01-15 00:00:00

  • Integrating Mechanical Force into Lung Development.

    abstract::In this issue of Developmental Cell, Tang et al. (2018) and Li et al. (2018) combine genetic manipulation, mechanical perturbation, and live imaging to show how mechanical forces and local growth factors intersect to influence epithelial behavior and cell fate specification within the developing lung. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2018.01.015

    authors: Hogan BLM

    更新日期:2018-02-05 00:00:00

  • Birth regulates the initiation of sensory map formation through serotonin signaling.

    abstract::Although the mechanisms underlying the spatial pattern formation of sensory maps have been extensively investigated, those triggering sensory map formation during development are largely unknown. Here we show that the birth of pups instructively and selectively regulates the initiation of barrel formation in the somat...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.09.002

    authors: Toda T,Homma D,Tokuoka H,Hayakawa I,Sugimoto Y,Ichinose H,Kawasaki H

    更新日期:2013-10-14 00:00:00

  • Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals.

    abstract::p120-catenin is an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. Despite recent advances in understanding the roles that p120-catenin and Kaiso play in downstream modulation of Wnt/beta-catenin signaling, the identity of t...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2006.09.022

    authors: Park JI,Ji H,Jun S,Gu D,Hikasa H,Li L,Sokol SY,McCrea PD

    更新日期:2006-11-01 00:00:00

  • Rho Flares Repair Local Tight Junction Leaks.

    abstract::Tight junctions contribute to epithelial barrier function by selectively regulating the quantity and type of molecules that cross the paracellular barrier. Experimental approaches to evaluate the effectiveness of tight junctions are typically global, tissue-scale measures. Here, we introduce Zinc-based Ultrasensitive ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.01.016

    authors: Stephenson RE,Higashi T,Erofeev IS,Arnold TR,Leda M,Goryachev AB,Miller AL

    更新日期:2019-02-25 00:00:00

  • Oligodendrocyte Neurofascin Independently Regulates Both Myelin Targeting and Sheath Growth in the CNS.

    abstract::Selection of the correct targets for myelination and regulation of myelin sheath growth are essential for central nervous system (CNS) formation and function. Through a genetic screen in zebrafish and complementary analyses in mice, we find that loss of oligodendrocyte Neurofascin leads to mistargeting of myelin to ce...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.10.016

    authors: Klingseisen A,Ristoiu AM,Kegel L,Sherman DL,Rubio-Brotons M,Almeida RG,Koudelka S,Benito-Kwiecinski SK,Poole RJ,Brophy PJ,Lyons DA

    更新日期:2019-12-16 00:00:00

  • A Self-Organized PLT/Auxin/ARR-B Network Controls the Dynamics of Root Zonation Development in Arabidopsis thaliana.

    abstract::During organogenesis, coherent organ growth arises from spatiotemporally coordinated decisions of individual cells. In the root of Arabidopsis thaliana, this coordination results in the establishment of a division and a differentiation zone. Cells continuously move through these zones; thus, a major question is how th...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2020.04.004

    authors: Salvi E,Rutten JP,Di Mambro R,Polverari L,Licursi V,Negri R,Dello Ioio R,Sabatini S,Ten Tusscher K

    更新日期:2020-05-18 00:00:00

  • Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs.

    abstract::The Par polarity complex creates mutually exclusive cortical domains in diverse animal cells. Activity of the atypical protein kinase C (aPKC) is a key output of the Par complex as phosphorylation removes substrates from the Par domain. Here, we investigate how diverse, apparently unrelated Par substrates couple phosp...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2015.09.016

    authors: Bailey MJ,Prehoda KE

    更新日期:2015-10-26 00:00:00

  • Pak GITs to Aurora-A.

    abstract::The protein kinase Aurora-A orchestrates key aspects of cell division, but its regulation has remained a major puzzle. That puzzle is now one step closer to being solved thanks to a recent paper by Zhao et al. appearing in the October 28(th) issue of Molecular Cell. In this work, the authors show that p21-activated ki...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2005.10.005

    authors: Cotteret S,Chernoff J

    更新日期:2005-11-01 00:00:00

  • piRNA Rules of Engagement.

    abstract::piRNAs are known to silence transposable elements, but not all piRNAs match transposon sequences. Recent studies from Shen et al. (2018) and Zhang et al. (2018) identify rules for piRNA target recognition in Caenorhabditis elegans. Permissive pairing rules allow targeting of essentially all germline mRNAs, while prote...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2018.03.006

    authors: Svendsen JM,Montgomery TA

    更新日期:2018-03-26 00:00:00

  • Cell-cycle-dependent spatial sequestration of the DnaA replication initiator protein in Bacillus subtilis.

    abstract::Initiation of DNA replication must be restricted to occur only once per cell cycle. In most bacteria, DnaA protein binds replication origins and promotes the initiation of DNA replication. We have found that in Bacillus subtilis, DnaA only colocalizes with origin regions at early or late stages of the cell cycle, when...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.09.010

    authors: Soufo CD,Soufo HJ,Noirot-Gros MF,Steindorf A,Noirot P,Graumann PL

    更新日期:2008-12-01 00:00:00

  • Tissue Sculpting by Fibrils.

    abstract::In this issue of Developmental Cell, Isabella and Horne-Badovinac (2016) show that Rab10 directs site-specific secretion of basement membrane components, which assemble into fibrils that spool out to elongate the Drosophila egg chamber. These findings establish the basement membrane's active role in tissue sculpting. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2016.06.028

    authors: Jayadev R,Sherwood DR

    更新日期:2016-07-11 00:00:00

  • Oscillation and polarity of E-cadherin asymmetries control actomyosin flow patterns during morphogenesis.

    abstract::Actomyosin flows are involved in a variety of cellular processes, including cytokinesis, cell migration, polarization, and morphogenesis. In epithelia, flow polarization orients cell deformations. It is unclear, however, how flows are polarized and how global patterns of junction remodeling emerge from flow polarizati...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.06.020

    authors: Levayer R,Lecuit T

    更新日期:2013-07-29 00:00:00

  • Maintaining muscle mitochondria via transsynaptic signaling.

    abstract::Dominant VAPB mutations are implicated in neurodegenerative disease, including amyotrophic lateral sclerosis and spinal muscular atrophy. In the current issue, Han et al. (2012) uncover a mechanism through which the secreted VAPB MSP domain regulates actin organization and mitochondrial function in muscle cells throug...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2012.01.021

    authors: Long JB,Van Vactor D

    更新日期:2012-02-14 00:00:00

  • Alpha-actinin is required for tightly regulated remodeling of the actin cortical network during cytokinesis.

    abstract::Localization of the actin crosslinking protein, alpha-actinin, to the cleavage furrow has been previously reported. However, its functions during cytokinesis remain poorly understood. We have analyzed the functions of alpha-actinin during cytokinesis by a combination of molecular manipulations and imaging-based techni...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2007.08.003

    authors: Mukhina S,Wang YL,Murata-Hori M

    更新日期:2007-10-01 00:00:00

  • Germ Cells Get by with a Little Cannibalistic Help from Their Friends.

    abstract::During development, primordial germ cells (PGCs) navigate a complex journey to generate the germline. In a recent paper in Nature Cell Biology, Nance and colleagues (Abdu et al., 2016) have discovered an unexpected step along the way: PGCs get cut in half by endodermal cells. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2016.12.003

    authors: Krishna S,Overholtzer M

    更新日期:2016-12-19 00:00:00