Abstract:
:Positioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate mesoderm (LPM), resulting in asymmetric positioning of the zebrafish liver. EphrinB1 in hepatoblasts regulates directional migration and mediates interactions with the LPM, where EphB3b controls polarity and movement of the LPM. EphB3b in the LPM concomitantly repels hepatoblasts to move leftward into the liver bud. Cellular protrusions controlled by Eph/Ephrin signaling mediate hepatoblast motility and long-distance cell-cell contacts with the LPM beyond immediate tissue interfaces. Mechanistically, intracellular EphrinB1 domains mediate EphB3b-independent hepatoblast extension formation, while EpB3b interactions cause their destabilization. We propose that bidirectional short- and long-distance cell interactions between epithelial and mesenchyme-like tissues coordinate liver bud formation and laterality via cell repulsion.
journal_name
Dev Celljournal_title
Developmental cellauthors
Cayuso J,Dzementsei A,Fischer JC,Karemore G,Caviglia S,Bartholdson J,Wright GJ,Ober EAdoi
10.1016/j.devcel.2016.10.009subject
Has Abstractpub_date
2016-11-07 00:00:00pages
316-328issue
3eissn
1534-5807issn
1878-1551pii
S1534-5807(16)30722-5journal_volume
39pub_type
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