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PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression.

Abstract：

:Preventing inappropriate gene expression in time and space is as fundamental as triggering the activation of tissue- or cell-type-specific factors at the correct developmental stage and in the correct cells. Here, we study the impact of Polycomb repressive complex 2 (PRC2) function on HoxA gene regulation. We analyze chromatin conformation of the HoxA cluster and its regulatory regions and show that in addition to the well-known role of PRC2 in silencing Hox genes via direct binding, its function is required for the changes in HoxA long-range interactions distinguishing proximal limbs from distal limbs. This effect stems from the differential PRC2 occupancy over the HoxA cluster and, at least in part, from the ability of PRC2-bound loci to engage in long-range contacts. Unexpectedly, PRC2 also impacts chromatin conformation in a way that promotes enhancer-promoter contacts required for proper HoxA expression, pointing to a dual role of PRC2 in gene regulation.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Gentile C,Berlivet S,Mayran A,Paquette D,Guerard-Millet F,Bajon E,Dostie J,Kmita M

doi

10.1016/j.devcel.2019.05.021

subject

Has Abstract

pub_date

2019-07-22 00:00:00

pages

184-196.e4

issue

2

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(19)30419-8

journal_volume

50

pub_type

杂志文章

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