当前位置： SCI文献检索 > DEVELOPMENTAL CELL期刊下所有文献 > Rsp1p, a J domain protein required for disassembly and assembly of microtubule organizing centers during the fission yeast cell cycle.

Rsp1p, a J domain protein required for disassembly and assembly of microtubule organizing centers during the fission yeast cell cycle.

Abstract：

:Regulation of microtubule organizing centers (MTOCs) orchestrates the reorganization of the microtubule (MT) cytoskeleton. In the fission yeast Schizosaccharomyces pombe, an equatorial MTOC (eMTOC) at the cell division site disassembles after cytokinesis, and multiple interphase MTOCs (iMTOCs) appear on the nucleus. Here, we show that, upon eMTOC disassembly, small satellites carrying MTOC components such as the gamma-tubulin complex travel in both directions along interphase MTs. We identify rsp1p, an MTOC protein required for eMTOC disassembly. In rsp1 loss-of-function mutants, the eMTOC persists and organizes an abnormal microtubule aster, while iMTOCs and satellites are greatly reduced. Conversely, rsp1p overexpression inhibits eMTOC formation. Rsp1p is a J domain protein that interacts with an hsp70. Thus, our findings suggest a model in which rsp1p is part of a chaperone-based mechanism that disassembles the eMTOC into satellites, contributing to the dynamic redistribution of MTOC components for organization of interphase microtubules.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Zimmerman S,Tran PT,Daga RR,Niwa O,Chang F

doi

10.1016/s1534-5807(04)00096-6

keywords:

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

497-509

issue

4

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(04)00096-6

journal_volume

6

pub_type

杂志文章

相关文献

DEVELOPMENTAL CELL文献大全
  • Memorizing Shape to Orient Cell Division.

    abstract：:A century ago, Oscar Hertwig discovered that cells orient their cleavage plane orthogonal to their long axis. Reporting recently in Nature, Bosveld et al. (2016) shed light on how, showing that NuMA/Mud localization at tricellular junctions provides mitotic cells with the memory of interphase shape used to orient clea...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2016.03.005

    authors： Michel M,Dahmann C

    更新日期：2016-03-21 00:00:00

  • A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis.

    abstract：:Neutrophils, in response to a chemoattractant gradient, undergo dynamic F-actin remodeling, a process important for their directional migration or chemotaxis. However, signaling mechanisms for chemoattractants to regulate the process are incompletely understood. Here, we characterized chemoattractant-activated signali...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2011.10.023

    authors： Tang W,Zhang Y,Xu W,Harden TK,Sondek J,Sun L,Li L,Wu D

    更新日期：2011-12-13 00:00:00

  • gurken and the I factor retrotransposon RNAs share common localization signals and machinery.

    abstract：:Drosophila gurken mRNA is localized by dynein-mediated transport to a crescent near the oocyte nucleus, thus targeting the TGFalpha signal and forming the primary embryonic axes. Here, we show that gurken and the I factor, a non-LTR retrotransposon, share a small consensus RNA stem loop of defined secondary structure,...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2005.04.012

    authors： Van De Bor V,Hartswood E,Jones C,Finnegan D,Davis I

    更新日期：2005-07-01 00:00:00

  • Nuclear architecture--an island no more.

    abstract：:The eukaryotic nucleus has been the neglected child of cell biology. The "International Symposium on Functional Organization of the Nucleus" held in January on Awaji Island, Japan, highlighted recent work on nuclear organization and function. Emerging from this conference was a holistic view in which diverse chemical ...

    journal_title：Developmental cell

    pub_type：

    doi：10.1016/j.devcel.2007.02.014

    authors： Dernburg AF,Misteli T

    更新日期：2007-03-01 00:00:00

  • Selective regulation of arterial branching morphogenesis by synectin.

    abstract：:Branching morphogenesis is a key process in the formation of vascular networks. To date, little is known regarding the molecular events regulating this process. We investigated the involvement of synectin in this process. In zebrafish embryos, synectin knockdown resulted in a hypoplastic dorsal aorta and hypobranched,...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2006.03.012

    authors： Chittenden TW,Claes F,Lanahan AA,Autiero M,Palac RT,Tkachenko EV,Elfenbein A,Ruiz de Almodovar C,Dedkov E,Tomanek R,Li W,Westmore M,Singh JP,Horowitz A,Mulligan-Kehoe MJ,Moodie KL,Zhuang ZW,Carmeliet P,Simons M

    更新日期：2006-06-01 00:00:00

  • Aberrant epigenetic landscape in cancer: how cellular identity goes awry.

    abstract：:Appropriate patterns of DNA methylation and histone modifications are required to assure cell identity, and their deregulation can contribute to human diseases, such as cancer. Our aim here is to provide an overview of how epigenetic factors, including genomic DNA methylation, histone modifications, and microRNA regul...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.devcel.2010.10.005

    authors： Berdasco M,Esteller M

    更新日期：2010-11-16 00:00:00

  • A Hierarchical Regulatory Landscape during the Multiple Stages of EMT.

    abstract：:Epithelial-mesenchymal transition (EMT) enables cells to gain migratory and invasive features underlined by major transcriptional and epigenetic reprogramming. However, most studies have focused on the endpoints of the EMT process, and the epistatic hierarchy of the transcriptional networks underlying EMT has remained...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2018.12.023

    authors： Meyer-Schaller N,Cardner M,Diepenbruck M,Saxena M,Tiede S,Lüönd F,Ivanek R,Beerenwinkel N,Christofori G

    更新日期：2019-02-25 00:00:00

  • Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content.

    abstract：:The intestine is an organ with an exceptionally high rate of cell turnover, and perturbations in this process can lead to severe diseases such as cancer or intestinal atrophy. Nutrition has a profound impact on intestinal volume and cellular architecture. However, how intestinal homeostasis is maintained in fluctuatin...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2018.08.011

    authors： Mattila J,Kokki K,Hietakangas V,Boutros M

    更新日期：2018-10-08 00:00:00

  • PREEParing for mitosis.

    abstract：:Reporting in Developmental Cell, Schlaitz et al. (2013) show that endoplasmic reticulum (ER) membrane exclusion from the mitotic spindle is an active process requiring REEP membrane proteins. REEP protein depletion results in ER membrane retention on the spindle and chromosomes, leading to defects in chromosome segreg...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2013.07.018

    authors： Burke B

    更新日期：2013-08-12 00:00:00

  • Dkk1 Controls Cell-Cell Interaction through Regulation of Non-nuclear β-Catenin Pools.

    abstract：:Dickkopf-1 (Dkk1) is a secreted Wnt antagonist with a well-established role in head induction during development. Numerous studies have emerged implicating Dkk1 in various malignancies and neurodegenerative diseases through an unknown mechanism. Using zebrafish gastrulation as a model for collective cell migration, we...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2019.10.026

    authors： Johansson M,Giger FA,Fielding T,Houart C

    更新日期：2019-12-16 00:00:00

  • A receptor for meningococcus: eliciting β-arrestin signaling for barrier breaching.

    abstract：:In a recent issue of Cell, Coureuil et al. (2010) show that type IV pili of Neisseria meningitidis-the causative bacterium of cerebrospinal meningitis-bind to the endothelial β2-adrenoceptor and elicit biased β-arrestin signaling resulting in microvilli formation and paracytotic bacterial migration. ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2010.12.011

    authors： Tourret J,Finlay BB

    更新日期：2011-01-18 00:00:00

  • Kinetochore-dependent microtubule rescue ensures their efficient and sustained interactions in early mitosis.

    abstract：:How kinetochores regulate microtubule dynamics to ensure proper kinetochore-microtubule interactions is unknown. Here, we studied this during early mitosis in Saccharomyces cerevisiae. When a microtubule shrinks and its plus end reaches a kinetochore bound to its lateral surface, the microtubule end attempts to tether...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2011.09.006

    authors： Gandhi SR,Gierliński M,Mino A,Tanaka K,Kitamura E,Clayton L,Tanaka TU

    更新日期：2011-11-15 00:00:00

  • Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle.

    abstract：:Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.devcel.2007.04.005

    authors： Cai H,Reinisch K,Ferro-Novick S

    更新日期：2007-05-01 00:00:00

  • Germ Cells Get by with a Little Cannibalistic Help from Their Friends.

    abstract：:During development, primordial germ cells (PGCs) navigate a complex journey to generate the germline. In a recent paper in Nature Cell Biology, Nance and colleagues (Abdu et al., 2016) have discovered an unexpected step along the way: PGCs get cut in half by endodermal cells. ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2016.12.003

    authors： Krishna S,Overholtzer M

    更新日期：2016-12-19 00:00:00

  • Regulation of angiogenesis by oxygen and metabolism.

    abstract：:Blood vessels form an important interface between the environment and the organism by carrying oxygen and nutrients to all cells and thus determining cellular metabolism. It is therefore not surprising that oxygen and metabolism influence the development of the vascular network. Here, we discuss recent insights regard...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.devcel.2009.01.003

    authors： Fraisl P,Mazzone M,Schmidt T,Carmeliet P

    更新日期：2009-02-01 00:00:00

  • A flip-flop switch in polarity signaling.

    abstract：:The Rho GTPase Cdc42 is essential for polarized growth of budding yeast. Temporal control of Cdc42 depends partly on the activity of its GTPase-activating proteins (GAPs). In this issue of Developmental Cell, Saito et al. report that Cdc42 GAP activity is regulated by the phospholipid composition of the bud-tip membra...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2007.10.008

    authors： Menon AK

    更新日期：2007-11-01 00:00:00

  • Epithelial Morphogenesis: Size Matters.

    abstract：:In this issue of Developmental Cell, Gibson and colleagues (Ramanathan et al., 2019) investigate the relationship between size and shape in epithelial cells. They find that cell size impacts cell shape, with unexpected consequences for epithelial growth and morphogenesis, particularly the clonal dynamics of epithelial...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2019.09.015

    authors： Thompson BJ

    更新日期：2019-10-07 00:00:00

  • Model organisms as a guide to mammalian aging.

    abstract：:Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/s1534-5807(01)00098-3

    authors： Tissenbaum HA,Guarente L

    更新日期：2002-01-01 00:00:00

  • Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.

    abstract：:During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in melanoblasts during embryogenesis causes defects in migration, cell-cycle progression, and cytokinesis. Rac1 null cells migrate markedly less efficiently, but s...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2011.07.008

    authors： Li A,Ma Y,Yu X,Mort RL,Lindsay CR,Stevenson D,Strathdee D,Insall RH,Chernoff J,Snapper SB,Jackson IJ,Larue L,Sansom OJ,Machesky LM

    更新日期：2011-10-18 00:00:00

  • Drosophila left/right asymmetry establishment is controlled by the Hox gene abdominal-B.

    abstract：:In Drosophila, left/right (LR) asymmetry is apparent in the directional looping of the gut and male genitalia. The dextral orientation of the organs depends on the activity of a single gene, MyosinID (myoID), whose mutation leads to a fully inverted LR axis, thus revealing the activity of a recessive sinistral pathway...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2012.11.013

    authors： Coutelis JB,Géminard C,Spéder P,Suzanne M,Petzoldt AG,Noselli S

    更新日期：2013-01-14 00:00:00

  • Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks.

    abstract：:A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed commitment regulates mammalian nephrogenesis. Intersectional studies using chromatin immunoprecipitation and transcriptional profiling identified direct target genes shared by each pathway within nephron progenitors. Wnt4 and Fgf8 are e...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2012.07.008

    authors： Park JS,Ma W,O'Brien LL,Chung E,Guo JJ,Cheng JG,Valerius MT,McMahon JA,Wong WH,McMahon AP

    更新日期：2012-09-11 00:00:00

  • Moonlighting at the Centrosome: RXRα Turns to Plk1.

    abstract：:One of the hardest working mitotic proteins, Polo-like kinase 1 (PLK1), functions at mitotic entry, cytokinesis, and many steps in between. In this issue, Xie et al. (2020) describe a centrosome-specific interaction between PLK1 and Retinoid X Receptor-α and they test selective inhibition of this interaction as an ant...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2020.11.027

    authors： Dos Santos A,Elowe S

    更新日期：2020-12-21 00:00:00

  • Exit from proliferation during leaf development in Arabidopsis thaliana: a not-so-gradual process.

    abstract：:Early leaf growth is sustained by cell proliferation and subsequent cell expansion that initiates at the leaf tip and proceeds in a basipetal direction. Using detailed kinematic and gene expression studies to map these stages during early development of the third leaf of Arabidopsis thaliana, we showed that the cell-c...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2011.11.011

    authors： Andriankaja M,Dhondt S,De Bodt S,Vanhaeren H,Coppens F,De Milde L,Mühlenbock P,Skirycz A,Gonzalez N,Beemster GT,Inzé D

    更新日期：2012-01-17 00:00:00

  • The undiscovered country: chromosome territories and the organization of transcription.

    abstract：:The interchromosome domain (ICD) model proposes that genes are selectively positioned at the surfaces of chromosome territories to facilitate their regulation. A paper in the May 13 issue of the Journal of Cell Biology provides evidence that supports a reinterpretation of this model. ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(02)00196-x

    authors： Kosak ST,Groudine M

    更新日期：2002-06-01 00:00:00

  • Morpholinos Do Not Elicit an Innate Immune Response during Early Xenopus Embryogenesis.

    abstract：:It has recently been reported that a common side effect of translation-blocking morpholino antisense oligonucleotides is the induction of a set of innate immune response genes in Xenopus embryos and that splicing-blocking morpholinos lead to unexpected off-target mis-splicing events. Here, we present an analysis of al...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.devcel.2019.04.019

    authors： Paraiso KD,Blitz IL,Zhou JJ,Cho KWY

    更新日期：2019-05-20 00:00:00

  • A major epigenetic programming mechanism guided by piRNAs.

    abstract：:A central enigma in epigenetics is how epigenetic factors are guided to specific genomic sites for their function. Previously, we reported that a Piwi-piRNA complex associates with the piRNA-complementary site in the Drosophila genome and regulates its epigenetic state. Here, we report that Piwi-piRNA complexes bind t...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2013.01.023

    authors： Huang XA,Yin H,Sweeney S,Raha D,Snyder M,Lin H

    更新日期：2013-03-11 00:00:00

  • The CXCL12/CXCR4 Axis Plays a Critical Role in Coronary Artery Development.

    abstract：:The chemokine CXCL12 and its receptor CXCR4 have many functions during embryonic and post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling in cardiac development and found that embryonic Cxcl12-null hearts lacked intra-ventricular coronary arteries (CAs) and exhibited absent or mispl...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2015.03.026

    authors： Ivins S,Chappell J,Vernay B,Suntharalingham J,Martineau A,Mohun TJ,Scambler PJ

    更新日期：2015-05-26 00:00:00

  • How to Make a Billion Parasites.

    abstract：:Transmission of the human parasite Brugia malayi relies on the sustained production of larvae in blood. In this issue of Developmental Cell,Foray et al. (2018) use methods developed in the model nematode C. elegans to reveal how a symbiotic bacterium supports the female germ cell development underlying this massive fe...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2018.04.006

    authors： Haag ES,Lo TW

    更新日期：2018-04-23 00:00:00

  • Real-Time Three-Dimensional Cell Segmentation in Large-Scale Microscopy Data of Developing Embryos.

    abstract：:We present the Real-time Accurate Cell-shape Extractor (RACE), a high-throughput image analysis framework for automated three-dimensional cell segmentation in large-scale images. RACE is 55-330 times faster and 2-5 times more accurate than state-of-the-art methods. We demonstrate the generality of RACE by extracting c...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2015.12.028

    authors： Stegmaier J,Amat F,Lemon WC,McDole K,Wan Y,Teodoro G,Mikut R,Keller PJ

    更新日期：2016-01-25 00:00:00

  • Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact Sites.

    abstract：:The extensive subcellular network of membrane contact sites plays central roles in organelle biogenesis and communication, yet the precise contributions of the involved machineries remain largely enigmatic. The yeast vacuole forms a membrane contact site with mitochondria, called vacuolar and mitochondrial patch (vCLA...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2018.05.011

    authors： González Montoro A,Auffarth K,Hönscher C,Bohnert M,Becker T,Warscheid B,Reggiori F,van der Laan M,Fröhlich F,Ungermann C

    更新日期：2018-06-04 00:00:00