The undiscovered country: chromosome territories and the organization of transcription.

abstract：:Centromeres form the site of chromosome attachment to microtubules during mitosis. Identity of these loci is maintained epigenetically by nucleosomes containing the histone H3 variant CENP-A. Propagation of CENP-A chromatin is uncoupled from DNA replication initiating only during mitotic exit. We now demonstrate that ...

journal_title：Developmental cell

authors： Silva MC,Bodor DL,Stellfox ME,Martins NM,Hochegger H,Foltz DR,Jansen LE

更新日期：2012-01-17 00:00:00

abstract：:Mbl is a bacterial actin homolog that controls cell morphogenesis in Bacillus subtilis. A functional GFP-Mbl fusion protein was used to examine the behavior of the helical cables formed by Mbl protein in live B. subtilis cells. The cables undergo dynamic changes during cell cycle progression. They are stable but not r...

journal_title：Developmental cell

authors： Carballido-López R,Errington J

更新日期：2003-01-01 00:00:00

abstract：:Microglia are the primary immune cells in the brain. Under physiological conditions, they typically stay in a "resting" state, with ramified processes continuously extending to and retracting from surrounding neural tissues. Whether and how such highly dynamic resting microglia functionally interact with surrounding n...

journal_title：Developmental cell

authors： Li Y,Du XF,Liu CS,Wen ZL,Du JL

更新日期：2012-12-11 00:00:00

abstract：:Endoplasmic reticulum-plasma membrane (ER-PM) junctions are conserved structures defined as regions of the ER that tightly associate with the plasma membrane. However, little is known about the mechanisms that tether these organelles together and why such connections are maintained. Using a quantitative proteomic appr...

journal_title：Developmental cell

authors： Manford AG,Stefan CJ,Yuan HL,Macgurn JA,Emr SD

更新日期：2012-12-11 00:00:00

abstract：:Oxysterol binding protein-related proteins (ORPs) are conserved lipid binding polypeptides, enriched at ER contacts sites. ORPs promote non-vesicular lipid transport and work as lipid sensors in the context of many cellular tasks, but the determinants of their distinct localization and function are not understood. Her...

journal_title：Developmental cell

authors： Encinar Del Dedo J,Idrissi FZ,Fernandez-Golbano IM,Garcia P,Rebollo E,Krzyzanowski MK,Grötsch H,Geli MI

更新日期：2017-12-04 00:00:00

abstract：:Reporting in Developmental Cell, Pereira et al. (2016) use in vitro lineage reprogramming insights to inform understanding of hematopoietic stem cell (HSC) development in vivo. They find Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors, akin to fibroblast-derived hemato-vascular precursors, in mouse placenta and emb...

journal_title：Developmental cell

authors： Calvanese V,Mikkola HK

更新日期：2016-03-07 00:00:00

abstract：:During development, primordial germ cells (PGCs) navigate a complex journey to generate the germline. In a recent paper in Nature Cell Biology, Nance and colleagues (Abdu et al., 2016) have discovered an unexpected step along the way: PGCs get cut in half by endodermal cells. ...

journal_title：Developmental cell

authors： Krishna S,Overholtzer M

更新日期：2016-12-19 00:00:00

abstract：:Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation...

journal_title：Developmental cell

authors： Wang X,Kopinke D,Lin J,McPherson AD,Duncan RN,Otsuna H,Moro E,Hoshijima K,Grunwald DJ,Argenton F,Chien CB,Murtaugh LC,Dorsky RI

更新日期：2012-09-11 00:00:00

abstract：:The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these ...

journal_title：Developmental cell

authors： Nyeng P,Heilmann S,Löf-Öhlin ZM,Pettersson NF,Hermann FM,Reynolds AB,Semb H

更新日期：2019-04-08 00:00:00

abstract：:In Drosophila, left/right (LR) asymmetry is apparent in the directional looping of the gut and male genitalia. The dextral orientation of the organs depends on the activity of a single gene, MyosinID (myoID), whose mutation leads to a fully inverted LR axis, thus revealing the activity of a recessive sinistral pathway...

journal_title：Developmental cell

authors： Coutelis JB,Géminard C,Spéder P,Suzanne M,Petzoldt AG,Noselli S

更新日期：2013-01-14 00:00:00

abstract：:As they enter mitosis, animal cells undergo profound actin-dependent changes in shape to become round. Here we identify the Cdk1 substrate, Ect2, as a central regulator of mitotic rounding, thus uncovering a link between the cell-cycle machinery that drives mitotic entry and its accompanying actin remodeling. Ect2 is ...

journal_title：Developmental cell

authors： Matthews HK,Delabre U,Rohn JL,Guck J,Kunda P,Baum B

更新日期：2012-08-14 00:00:00

abstract：:Initiation of DNA replication must be restricted to occur only once per cell cycle. In most bacteria, DnaA protein binds replication origins and promotes the initiation of DNA replication. We have found that in Bacillus subtilis, DnaA only colocalizes with origin regions at early or late stages of the cell cycle, when...

journal_title：Developmental cell

authors： Soufo CD,Soufo HJ,Noirot-Gros MF,Steindorf A,Noirot P,Graumann PL

更新日期：2008-12-01 00:00:00

abstract：:The role of Lefty2 in left-right patterning was investigated by analysis of mutant mice that lack asymmetric expression of lefty2. These animals exhibited various situs defects including left isomerism. The asymmetric expression of nodal was prolonged and the expression of Pitx2 was upregulated in the mutant embryos. ...

journal_title：Developmental cell

authors： Meno C,Takeuchi J,Sakuma R,Koshiba-Takeuchi K,Ohishi S,Saijoh Y,Miyazaki J,ten Dijke P,Ogura T,Hamada H

更新日期：2001-07-01 00:00:00

abstract：:Inherited mtDNA mutations cause severe human disease. In most species, mitochondria are inherited maternally through mechanisms that are poorly understood. Genes that specifically control the inheritance of mitochondria in the germline are unknown. Here, we show that the long isoform of the protein Oskar regulates the...

journal_title：Developmental cell

authors： Hurd TR,Herrmann B,Sauerwald J,Sanny J,Grosch M,Lehmann R

更新日期：2016-12-05 00:00:00

abstract：:The serine threonine kinase Akt is a core survival factor that underlies a variety of human diseases. Although regulatory phosphorylation and dephosphorylation have been well documented, the other posttranslational mechanisms that modulate Akt activity remain unclear. We show here that tetratricopeptide repeat domain ...

journal_title：Developmental cell

authors： Suizu F,Hiramuki Y,Okumura F,Matsuda M,Okumura AJ,Hirata N,Narita M,Kohno T,Yokota J,Bohgaki M,Obuse C,Hatakeyama S,Obata T,Noguchi M

更新日期：2009-12-01 00:00:00

abstract：:Bazooka/Par-3 (Baz) is a key regulator of cell polarity in epithelial cells and neuroblasts (NBs). Phosphorylation of Baz by PAR-1 and aPKC is required for its function in epithelia, but little is known about the dephosphorylation mechanisms that antagonize the activities of these kinases or about the relevance of Baz...

journal_title：Developmental cell

authors： Krahn MP,Egger-Adam D,Wodarz A

更新日期：2009-06-01 00:00:00

abstract：:Morphological constancy is universal in developing systems. It is unclear whether precise morphogenesis stems from faithful mechanical interpretation of gene expression patterns. We investigate the formation of the cephalic furrow, an epithelial fold that is precisely positioned with a linear morphology. Fold initiati...

journal_title：Developmental cell

authors： Eritano AS,Bromley CL,Bolea Albero A,Schütz L,Wen FL,Takeda M,Fukaya T,Sami MM,Shibata T,Lemke S,Wang YC

更新日期：2020-04-20 00:00:00

abstract：:Transcriptional mediators of cell stress pathways, including HIF1α, ATF4, and p53, are key to normal development and play critical roles in disease, including ischemia and cancer. Despite their importance, mechanisms by which pathways mediated by these transcription factors interact with one another are not fully unde...

journal_title：Developmental cell

authors： Guimarães-Camboa N,Stowe J,Aneas I,Sakabe N,Cattaneo P,Henderson L,Kilberg MS,Johnson RS,Chen J,McCulloch AD,Nobrega MA,Evans SM,Zambon AC

更新日期：2015-06-08 00:00:00

abstract：:Cell stress often triggers inflammation as a protective response to tissue damage or infection. In this issue of Developmental Cell, Sullivan et al. (2020) reveal an unexpected role for TRAIL receptors in ER-stress-induced inflammation. ...

journal_title：Developmental cell

authors： Roca Portoles A,Tait SWG

更新日期：2020-03-23 00:00:00

abstract：:The 6th European Meiosis Workshop, sponsored by EMBO and organized by Franz Klein of the University of Vienna, met in mid-September. More than 150 participants who have not discovered anything more interesting than sex gathered in a bucolic Alpine valley near the town of Obertraun, Austria, surrounded by granite massi...

journal_title：Developmental cell

authors： Dernburg AF

更新日期：2003-11-01 00:00:00

abstract：:Inflammatory pathways protect the body from infection and promote healing following injury. Recent reports demonstrate the surprising involvement of these pathways during hematopoietic stem cell emergence from the hemogenic endothelium in both zebrafish and mice. ...

journal_title：Developmental cell

authors： Veldman MB,Lin S

更新日期：2014-12-08 00:00:00

abstract：:The spinal cord and mesodermal tissues of the trunk such as the vertebral column and skeletal musculature derive from neuro-mesodermal progenitors (NMPs). Sox2, Brachyury (T), and Tbx6 have been correlated with NMP potency and lineage choice; however, their exact role and interaction in these processes have not yet be...

journal_title：Developmental cell

authors： Koch F,Scholze M,Wittler L,Schifferl D,Sudheer S,Grote P,Timmermann B,Macura K,Herrmann BG

更新日期：2017-09-11 00:00:00

abstract：:Because mitochondria have outer and inner membranes, the fusion of two mitochondria requires the coordinated fusion of four lipid bilayers. Fusion of the outer membranes requires mitofusins. A new study published in Cell (Meeusen et al., 2006) shows that inner membrane fusion requires the dynamin-related protein Mgm1/...

journal_title：Developmental cell

authors： Chan DC

更新日期：2006-11-01 00:00:00

abstract：:High-molecular-weight hyaluronan, a major component of the extracellular matrix, is anti-oncogenic, whereas low-molecular-weight hyaluronan is pro-oncogenic, though the mechanisms underlying the size-dependent opposite bioactivities of hyaluronan remain uncertain. We show here that treatment with high-molecular-weight...

journal_title：Developmental cell

authors： Ooki T,Murata-Kamiya N,Takahashi-Kanemitsu A,Wu W,Hatakeyama M

更新日期：2019-05-20 00:00:00

abstract：:The conserved Hedgehog signaling pathway is essential for embryonic development and tissue homeostasis and is tightly regulated. In this issue of Developmental Cell, Ma et al. (2016) demonstrate that sumoylation works in parallel with phosphorylation to stabilize Smoothened, antagonizing its ubiquitination and subsequ...

journal_title：Developmental cell

authors： Qi Y,Liu H,Lin X

更新日期：2016-11-21 00:00:00

abstract：:In this issue of Developmental Cell, Gibson and colleagues (Ramanathan et al., 2019) investigate the relationship between size and shape in epithelial cells. They find that cell size impacts cell shape, with unexpected consequences for epithelial growth and morphogenesis, particularly the clonal dynamics of epithelial...

journal_title：Developmental cell

authors： Thompson BJ

更新日期：2019-10-07 00:00:00

abstract：:The role of mitochondria in Drosophila programmed cell death remains unclear, although certain gene products that regulate cell death seem to be evolutionarily conserved. We find that developmental programmed cell death stimuli in vivo and multiple apoptotic stimuli ex vivo induce dramatic mitochondrial fragmentation ...

journal_title：Developmental cell

authors： Goyal G,Fell B,Sarin A,Youle RJ,Sriram V

更新日期：2007-05-01 00:00:00

abstract：:TORC1 is arguably the best-studied regulator of cellular growth in eukaryotes. However, its activity has not been assessed in vivo in developing multicellular organisms. Two studies in this issue of Developmental Cell (Kim et al., 2017; Romero-Pozuelo et al., 2017) surprisingly reveal a patchy, cell-cycle-controlled p...

journal_title：Developmental cell

authors： Stocker H

更新日期：2017-08-21 00:00:00

abstract：:Numerous signals drive the proliferative expansion of the distal endoderm and the underlying mesenchyme during lung branching morphogenesis, but little is known about how these signals are integrated. Here, we show by analysis of conditional double mutants that the two T-box transcription factor genes Tbx2 and Tbx3 ac...

journal_title：Developmental cell

authors： Lüdtke TH,Rudat C,Wojahn I,Weiss AC,Kleppa MJ,Kurz J,Farin HF,Moon A,Christoffels VM,Kispert A

更新日期：2016-10-24 00:00:00

abstract：:Boundary formation and epithelialization are crucial processes in the morphological segmentation of vertebrate somites. By a genetic screening procedure with zebrafish, we identified two genes, integrinalpha5 (itga5) and fibronectin (fn), required for these processes. Fibronectin proteins accumulate at somite boundari...

journal_title：Developmental cell

authors： Koshida S,Kishimoto Y,Ustumi H,Shimizu T,Furutani-Seiki M,Kondoh H,Takada S

更新日期：2005-04-01 00:00:00