Abstract：
:Transmission of the human parasite Brugia malayi relies on the sustained production of larvae in blood. In this issue of Developmental Cell,Foray et al. (2018) use methods developed in the model nematode C. elegans to reveal how a symbiotic bacterium supports the female germ cell development underlying this massive fecundity.
journal_name
Dev Celljournal_title
Developmental cellauthors
Haag ES,Lo TWdoi
10.1016/j.devcel.2018.04.006subject
Has Abstractpub_date
2018-04-23 00:00:00pages
147-148issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(18)30281-8journal_volume
45pub_type
评论,杂志文章abstract：:Morphological constancy is universal in developing systems. It is unclear whether precise morphogenesis stems from faithful mechanical interpretation of gene expression patterns. We investigate the formation of the cephalic furrow, an epithelial fold that is precisely positioned with a linear morphology. Fold initiati...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.02.012
更新日期：2020-04-20 00:00:00
abstract：:In Drosophila, left/right (LR) asymmetry is apparent in the directional looping of the gut and male genitalia. The dextral orientation of the organs depends on the activity of a single gene, MyosinID (myoID), whose mutation leads to a fully inverted LR axis, thus revealing the activity of a recessive sinistral pathway...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.11.013
更新日期：2013-01-14 00:00:00
abstract：:Alzheimer's disease remains a formidable challenge for therapeutic management. In a recent report in Nature Structural and Molecular Biology, Cohen et al. (2015) present intriguing results showing that "designer" molecular chaperones may hold the key to an evolutionarily conserved program for management of toxic oligo...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.03.009
更新日期：2015-03-23 00:00:00
abstract：:Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the adipogenic fate of FAPs in injured and diseased muscle by restraining Hedgehog signaling. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2017.06.023
更新日期：2017-07-24 00:00:00
abstract：:Understanding cells as integrated systems requires that we systematically decipher how single genes affect multiple biological processes and how processes are functionally linked. Here, we used multiprocess phenotypic profiling, combining high-resolution 3D confocal microscopy and multiparametric image analysis, to si...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.09.005
更新日期：2014-10-27 00:00:00
abstract：:Positive autoregulation is an effective mechanism for the long-term maintenance of a transcription factor's expression. This strategy is widely deployed in cell lineages, where the autoregulatory factor controls the activity of a battery of genes that constitute the differentiation program of a postmitotic cell type. ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.02.005
更新日期：2014-04-14 00:00:00
abstract：:The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signalin...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2008.11.010
更新日期：2008-12-01 00:00:00
abstract：:Successive cell divisions during embryonic cleavage create increasingly smaller cells, so intracellular structures must adapt accordingly. Mitotic spindle size correlates with cell size, but the mechanisms for this scaling remain unclear. Using live cell imaging, we analyzed spindle scaling during embryo cleavage in t...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.04.022
更新日期：2018-05-21 00:00:00
abstract：:Oncogenic alterations in epithelial tissues often trigger apoptosis, suggesting an evolutionary mechanism by which organisms eliminate aberrant cells from epithelia. In Drosophila imaginal epithelia, clones of cells mutant for tumor suppressors, such as scrib or dlg, lose their polarity and are eliminated by cell deat...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.01.002
更新日期：2009-03-01 00:00:00
abstract：:Eukaryotic genomes are organized within the nucleus through interactions with inner nuclear membrane (INM) proteins. How chromatin tethering to the INM is controlled in interphase and how this process contributes to subsequent mitotic nuclear envelope (NE) remodeling remains unclear. We have probed these fundamental q...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.01.028
更新日期：2020-04-06 00:00:00
abstract：:Epithelial cells acquire mesenchymal characteristics during development, wound healing and inflammation, and in cancer and fibrosis. With increasing appreciation of different roles of epithelial-mesenchymal transition (EMT), we address the question of how to define and recognize EMT processes and discuss their propert...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2019.04.026
更新日期：2019-05-06 00:00:00
abstract：:Many different intercellular signaling pathways are known but, for most, it is unclear whether they can generate oscillating cell behaviors. Here we use time-lapse analysis of Drosophila embryogenesis to show that oenocytes delaminate from the ectoderm in discrete bursts of three. This pulsatile process has a 1 hour p...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.10.016
更新日期：2004-12-01 00:00:00
abstract：:Germ cells, the cells that give rise to sperm and egg, maintain the potential to recreate all cell types in a new individual. This wide developmental potential, or totipotency, is manifested in unusual tumors called teratomas, in which germ cells undergo somatic differentiation. Although recent studies have implicated...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.08.003
更新日期：2009-09-01 00:00:00
abstract：:In a recent issue of Nature, Bohnert and Kenyon (2017) describe a signaling pathway that prevents transgenerational inheritance of cytoplasmic protein aggregates. Fertilizing sperm trigger aggregate clearance in the ovum by a microautophagy-like effector mechanism mediated by inter-organelle communication between lyso...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2017.12.016
更新日期：2018-01-08 00:00:00
abstract：:Lysosomes degrade macromolecular cargos, recycle catabolites, and serve as signaling platforms to maintain cell homeostasis, but their role at the tissue level is unclear. Here, we investigate lysosome regulation and function during C. elegans molting, a specialized extracellular matrix (ECM) remodeling process essent...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.10.020
更新日期：2020-01-06 00:00:00
abstract：:Inherited mtDNA mutations cause severe human disease. In most species, mitochondria are inherited maternally through mechanisms that are poorly understood. Genes that specifically control the inheritance of mitochondria in the germline are unknown. Here, we show that the long isoform of the protein Oskar regulates the...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.11.004
更新日期：2016-12-05 00:00:00
abstract：:Epithelial tubes are found in many vital organs and require uniform and correct tube diameters for optimal function. Tube size depends on apical membrane growth and subapical cytoskeletal reorganization, but the cues that coordinate these events to ensure functional tube shape remain elusive. We find that epithelial t...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.07.012
更新日期：2005-09-01 00:00:00
abstract：:Regulating the osmotic pressure of our body fluids relies on osmosensory neurons that depolarize when their volume decreases. Recently in Neuron, Prager-Khoutorsky et al. (2014) report that this depolarization arises from direct interactions between the transient receptor potential channel TRPV1 and microtubules, whic...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2014.08.012
更新日期：2014-08-25 00:00:00
abstract：:Mbl is a bacterial actin homolog that controls cell morphogenesis in Bacillus subtilis. A functional GFP-Mbl fusion protein was used to examine the behavior of the helical cables formed by Mbl protein in live B. subtilis cells. The cables undergo dynamic changes during cell cycle progression. They are stable but not r...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00403-3
更新日期：2003-01-01 00:00:00
abstract：:The protein kinase Aurora-A orchestrates key aspects of cell division, but its regulation has remained a major puzzle. That puzzle is now one step closer to being solved thanks to a recent paper by Zhao et al. appearing in the October 28(th) issue of Molecular Cell. In this work, the authors show that p21-activated ki...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2005.10.005
更新日期：2005-11-01 00:00:00
abstract：:TGF-beta superfamily signaling pathways emerged with the evolution of multicellular animals, suggesting that these pathways contribute to the increased diversity and complexity required for the development and homeostasis of these organisms. In this review we begin by exploring some key developmental and disease proce...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2009.02.012
更新日期：2009-03-01 00:00:00
abstract：:Because mitochondria have outer and inner membranes, the fusion of two mitochondria requires the coordinated fusion of four lipid bilayers. Fusion of the outer membranes requires mitofusins. A new study published in Cell (Meeusen et al., 2006) shows that inner membrane fusion requires the dynamin-related protein Mgm1/...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.10.009
更新日期：2006-11-01 00:00:00
abstract：:MEF2 transcription factors are well-established regulators of muscle development. We have discovered an unanticipated role for MEF2C in the neural crest, where tissue-specific inactivation results in neonatal lethality due to severe craniofacial defects. We show that MEF2C is required for expression of the Dlx5, Dlx6,...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.03.007
更新日期：2007-04-01 00:00:00
abstract：:During embryonic development, cells must establish fates, morphologies, and behaviors in coordination with one another to form a functional body. A prevalent hypothesis for how this coordination is achieved is that each cell's fate and behavior is determined by a defined mixture of RNAs. Only recently has it become po...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.07.025
更新日期：2016-08-22 00:00:00
abstract：:Epithelial reorganization involves coordinated changes in cell shapes and movements. This restructuring occurs during formation of placodes, ectodermal thickenings that initiate the morphogenesis of epithelial organs including hair, mammary gland, and tooth. Signaling pathways in ectodermal placode formation are well ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.02.003
更新日期：2014-03-10 00:00:00
abstract：:Although autophagy is being pursued as a therapeutic target in clinical oncology trials, its effects on metastasis, the principal cause of cancer mortality, remain unclear. Here, we utilize mammary cancer models to temporally delete essential autophagy regulators during carcinoma progression. Though genetic ablation o...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.01.025
更新日期：2020-03-09 00:00:00
abstract：:Trunk neural crest cells are generated at the border between the neural plate and nonneural ectoderm, where they initiate a distinct program of gene expression, undergo an epithelial-mesenchymal transition (EMT), and delaminate from the neuroepithelium. Here, we provide evidence that members of three families of trans...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.12.010
更新日期：2005-02-01 00:00:00
abstract：:In Drosophila, commitment of a cell to a sense organ precursor (SOP) fate requires bHLH proneural transcription factor upregulation, a process that depends in most cases on the interplay of proneural gene autoregulation and inhibitory Notch signaling. A subset of SOPs are selected by a recruitment pathway involving EG...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.09.015
更新日期：2004-11-01 00:00:00
abstract：:The Drosophila gene neuralized (neur) has long been recognized to be essential for the proper execution of a wide variety of processes mediated by the Notch (N) pathway, but its role in the pathway has been elusive. In this report, we present genetic and biochemical evidence that Neur is a RING-type, E3 ubiquitin liga...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(01)00092-2
更新日期：2001-12-01 00:00:00
abstract：:Genome condensation during mitosis presents a chromatin landscape largely inaccessible to RNA polymerase II and most transcription factors. Caravaca et al. (2013) now report in Genes and Development that the pioneer transcription factor FOXA1 is retained at mitotic chromosomes, bookmarking the genome to enable gene ex...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2013.02.005
更新日期：2013-02-25 00:00:00
