Abstract：
:Germ cells, the cells that give rise to sperm and egg, maintain the potential to recreate all cell types in a new individual. This wide developmental potential, or totipotency, is manifested in unusual tumors called teratomas, in which germ cells undergo somatic differentiation. Although recent studies have implicated RNA regulation, the mechanism that normally prevents the loss of germ cell identity remains unexplained. In C. elegans, a teratoma is induced in the absence of the conserved RNA-binding protein GLD-1. Here, we demonstrate that GLD-1 represses translation of CYE-1/cyclin E during meiotic prophase, which prevents germ cells from re-entering mitosis and inducing embryonic-like transcription. We describe a mechanism that prevents precocious mitosis in germ cells undergoing meiosis, propose that this mechanism maintains germ cell identity by delaying the onset of embryonic gene activation until after fertilization, and provide a paradigm for the possible origin of human teratomas.
journal_name
Dev Celljournal_title
Developmental cellauthors
Biedermann B,Wright J,Senften M,Kalchhauser I,Sarathy G,Lee MH,Ciosk Rdoi
10.1016/j.devcel.2009.08.003subject
Has Abstractpub_date
2009-09-01 00:00:00pages
355-64issue
3eissn
1534-5807issn
1878-1551pii
S1534-5807(09)00340-2journal_volume
17pub_type
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