Abstract:
:Trunk neural crest cells are generated at the border between the neural plate and nonneural ectoderm, where they initiate a distinct program of gene expression, undergo an epithelial-mesenchymal transition (EMT), and delaminate from the neuroepithelium. Here, we provide evidence that members of three families of transcription induce these properties in premigratory neural crest cells. Sox9 acts to provide the competence for neural crest cells to undergo an EMT and is required for trunk neural crest survival. In the absence of Sox9, cells apoptose prior to or shortly after delamination. Slug/Snail, in the presence of Sox9, is sufficient to induce an EMT in neural epithelial cells, while FoxD3 regulates the expression of cell-cell adhesion molecules required for neural crest migration. Together, the data suggest a model in which a combination of transcription factors regulates the acquisition of the diverse properties of neural crest cells.
journal_name
Dev Celljournal_title
Developmental cellauthors
Cheung M,Chaboissier MC,Mynett A,Hirst E,Schedl A,Briscoe Jdoi
10.1016/j.devcel.2004.12.010keywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
179-92issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(04)00462-9journal_volume
8pub_type
杂志文章abstract::Nakada et al. revisit the controversial question of whether membrane lipids are able to diffuse from the axon of a neuron into the soma. Using single molecule imaging of a fluorescent phospholipid, the authors show that a diffusion barrier in the axon initial segment blocks the diffusion of lipids. ...
journal_title:Developmental cell
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journal_title:Developmental cell
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doi:10.1016/s1534-5807(04)00020-6
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journal_title:Developmental cell
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