Abstract:
:In this issue of Developmental Cell, Marhavý et al. (2011) uncover a transcription-independent molecular mechanism of interaction between auxin and cytokinin in the regulation of plant meristem function. By modulating endocytic trafficking of PIN1, cytokinin controls auxin flux and, therefore, auxin gradients.
journal_name
Dev Celljournal_title
Developmental cellauthors
Stepanova AN,Alonso JMdoi
10.1016/j.devcel.2011.09.016subject
Has Abstractpub_date
2011-10-18 00:00:00pages
608-10issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(11)00414-Xjournal_volume
21pub_type
评论,杂志文章abstract::What are the thermodynamic costs of development? In this issue of Developmental Cell, Rodenfels et al. (2019) demonstrate that the high energetic cost of coordinated cell division that is regulated by phospho-signaling gives rise to a measurable periodicity in the heat dissipated during zebrafish embryogenesis. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2019.02.016
更新日期:2019-03-11 00:00:00
abstract::In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct skeletal stem cell (SSC) commitment and differentiation. However, the mechanisms by which the SSC-ECM interface is regulated and the outcome of such interactions on stem cell fate in vivo remain unknown. Here we demonstrate...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.04.011
更新日期:2013-05-28 00:00:00
abstract::Cells that undergo epithelial-to-mesenchymal transitions (EMTs) commonly switch from expressing E-cadherin to N-cadherin. But why this occurs is not well understood. In the current issue of Developmental Cell, Scarpa et al. (2015) identify a reason: cadherin switching controls Rac signaling to determine how cell locom...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.08.002
更新日期:2015-08-24 00:00:00
abstract::Gene expression often requires interaction between promoters and distant enhancers, which occur within the context of highly organized topologically associating domains (TADs). Using a series of engineered chromosomal rearrangements at the Shh locus, we carried out an extensive fine-scale characterization of the facto...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.10.015
更新日期:2016-12-05 00:00:00
abstract::Initiation of DNA replication must be restricted to occur only once per cell cycle. In most bacteria, DnaA protein binds replication origins and promotes the initiation of DNA replication. We have found that in Bacillus subtilis, DnaA only colocalizes with origin regions at early or late stages of the cell cycle, when...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.09.010
更新日期:2008-12-01 00:00:00
abstract::Dickkopf-1 (Dkk1) is a secreted Wnt antagonist with a well-established role in head induction during development. Numerous studies have emerged implicating Dkk1 in various malignancies and neurodegenerative diseases through an unknown mechanism. Using zebrafish gastrulation as a model for collective cell migration, we...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.10.026
更新日期:2019-12-16 00:00:00
abstract::How cold-blooded animals acclimate to temperature and what determines the limits of their viable temperature range are not understood. Here, we show that Drosophila alter their dietary preference from yeast to plants when temperatures drop below 15°C and that the different lipids present in plants improve survival at ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.05.028
更新日期:2018-09-24 00:00:00
abstract::A central enigma in epigenetics is how epigenetic factors are guided to specific genomic sites for their function. Previously, we reported that a Piwi-piRNA complex associates with the piRNA-complementary site in the Drosophila genome and regulates its epigenetic state. Here, we report that Piwi-piRNA complexes bind t...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.01.023
更新日期:2013-03-11 00:00:00
abstract::The Drosophila lipoprotein particle, Lipophorin, bears lipid-linked morphogens on its surface and is required for long-range signaling activity of Wingless and Hedgehog. Heparan sulfate proteoglycans are also critical for trafficking and signaling of these morphogens. Here we show that Lipophorin interacts with the he...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2007.04.019
更新日期:2007-07-01 00:00:00
abstract::Novel body structures are often generated by the redeployment of ancestral components of the genome. In this issue of Developmental Cell, Glassford et al. (2015) present a thorough analysis of the co-option of a gene regulatory network in the origin of an evolutionary novelty. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.08.022
更新日期:2015-09-14 00:00:00
abstract::Orientation of cell division is a vital aspect of tissue morphogenesis and growth. Asymmetric divisions generate cell fate diversity and epithelial stratification, whereas symmetric divisions contribute to tissue growth, spreading, and elongation. Here, we describe a mechanism for positioning the spindle in symmetric ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.01.002
更新日期:2012-04-17 00:00:00
abstract::We developed a comprehensive dataset that samples the mouse transcriptome every 6 hr, from gastrulation through organogenesis. We observe an abrupt increase in overall transcript diversity at the onset of organogenesis (e8.0); the genes that comprise these changes are preferentially clustered along chromosome 7 and co...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2007.10.004
更新日期:2007-12-01 00:00:00
abstract::The shape of most complex organ systems arises from the directed migration of cohesive groups of cells. Here, we dissect the role of the chemokine guidance receptor Cxcr4b in regulating the collective migration of one such cohesive tissue, the zebrafish lateral line primordium. Using in vivo imaging, we show that the ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.02.019
更新日期:2006-05-01 00:00:00
abstract::Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling functions require precise regulation of lysosomal cholesterol content. In Niemann-Pick type C (NPC), loss of the cholestero...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.11.016
更新日期:2020-12-07 00:00:00
abstract::Cell division axes during development are specified in different orientations to establish multicellular assemblies, but the mechanisms that generate division axis diversity remain unclear. We show here that patterns of cell contact provide cues that diversify cell division orientation by modulating cortical non-muscl...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.06.020
更新日期:2018-08-06 00:00:00
abstract::The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR) complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent years. It has become increasingly evident that these regulatory circuits control some of the most fundamental aspects of metabolism, c...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2007.03.020
更新日期:2007-04-01 00:00:00
abstract::The complex muscle patterns of higher organisms arise as migrating myoblasts are guided toward and connect with specific attachment sites. We review here the current understanding of myotube migration, focusing on its dynamic nature and the few molecular cues that have been identified to date. Much of this knowledge c...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2004.06.010
更新日期:2004-07-01 00:00:00
abstract::Positioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.10.009
更新日期:2016-11-07 00:00:00
abstract::In this issue of Developmental Cell, Weavers and Skaer (2013) show that interplay between two opposing forces generated by tip cell attachment to muscles and migration of kink cells allows for the formation of the looped shape and positioning of renal tubules within the body of a fly larva. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2013.10.021
更新日期:2013-11-11 00:00:00
abstract::The interchromosome domain (ICD) model proposes that genes are selectively positioned at the surfaces of chromosome territories to facilitate their regulation. A paper in the May 13 issue of the Journal of Cell Biology provides evidence that supports a reinterpretation of this model. ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00196-x
更新日期:2002-06-01 00:00:00
abstract::The Drosophila compound eye consists of approximately 750 independently functioning ommatidia, each containing two photoreceptor subpopulations. The outer photoreceptors participate in motion detection, while the inner photoreceptors contribute to color vision. Although the inner photoreceptors, R7 and R8, terminally ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00156-4
更新日期:2003-06-01 00:00:00
abstract::Growth and development are coordinated by an array of intercellular communications. Known plant signaling molecules include phytohormones and hormone peptides. Although both classes can be implicated in the same developmental processes, little is known about the interplay between phytohormone action and peptide signal...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.02.002
更新日期:2012-03-13 00:00:00
abstract::Epithelial reorganization involves coordinated changes in cell shapes and movements. This restructuring occurs during formation of placodes, ectodermal thickenings that initiate the morphogenesis of epithelial organs including hair, mammary gland, and tooth. Signaling pathways in ectodermal placode formation are well ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.02.003
更新日期:2014-03-10 00:00:00
abstract::In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2019.05.030
更新日期:2019-06-03 00:00:00
abstract::To maintain mechanical homeostasis, cells must recognize and respond to changes in cytoskeletal integrity. By imaging live cells expressing fluorescently tagged cytoskeletal proteins, we observed that actin stress fibers undergo local, acute, force-induced elongation and thinning events that compromise their stress tr...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.08.008
更新日期:2010-09-14 00:00:00
abstract::During zebrafish gastrulation, mesendoderm progenitor cells differentiate to mesoderm or endoderm cells. In this issue of Developmental Cell, Barone and colleagues (2017) show that the interplay between cell-cell contact duration and morphogen signaling can control this fate segregation, providing a new framework for ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2017.10.006
更新日期:2017-10-23 00:00:00
abstract::Understanding the mechanisms driving tissue and organ formation requires knowledge across scales. How do signaling pathways specify distinct tissue types? How does the patterning system control morphogenesis? How do these processes evolve? The Drosophila egg chamber, where EGF and BMP signaling intersect to specify un...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2017.02.018
更新日期:2017-05-22 00:00:00
abstract::piRNAs are known to silence transposable elements, but not all piRNAs match transposon sequences. Recent studies from Shen et al. (2018) and Zhang et al. (2018) identify rules for piRNA target recognition in Caenorhabditis elegans. Permissive pairing rules allow targeting of essentially all germline mRNAs, while prote...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2018.03.006
更新日期:2018-03-26 00:00:00
abstract::The mTOR kinase controls cell growth, proliferation, and survival through two distinct multiprotein complexes, mTORC1 and mTORC2. mTOR and mLST8 are in both complexes, while raptor and rictor are part of only mTORC1 and mTORC2, respectively. To investigate mTORC1 and mTORC2 function in vivo, we generated mice deficien...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.10.007
更新日期:2006-12-01 00:00:00
abstract::Polarity is a prominent feature of both chemotaxis and cytokinesis. In chemotaxis, polarity is established by local accumulation of PI(3,4,5)P3 at the cell's leading edge, achieved through temporal and spatial regulation of PI3 kinases and the tumor suppressor, PTEN. We find that as migrating D. discoideum cells round...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.02.010
更新日期:2005-04-01 00:00:00